An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats

An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats

Adrenal demedullation in young adult, spontaneously hypertensive rats( SHRs) results in blood pressure reduction. However, inconsistent postoperative care of demedullated animals may results in indifferent study findings. The study aims to determine whether an improved method could prevent elevati...

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Main Authors: Mohd Noor, Noriah, Abdullah, Aszrin, Abdul Razak, Tariq
Format: Conference or Workshop Item
Language:English
Published: 2011
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/10182/
http://irep.iium.edu.my/10182/
http://irep.iium.edu.my/10182/2/Chronic_blood_pressure.pdf
id iium-10182
recordtype eprints
spelling iium-101822012-02-21T08:43:16Z http://irep.iium.edu.my/10182/ An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats Mohd Noor, Noriah Abdullah, Aszrin Abdul Razak, Tariq R Medicine (General) Adrenal demedullation in young adult, spontaneously hypertensive rats( SHRs) results in blood pressure reduction. However, inconsistent postoperative care of demedullated animals may results in indifferent study findings. The study aims to determine whether an improved method could prevent elevation of blood pressure in young adult SHRs. Fourteen young male and female SHRs weighing 200-270g and 150-170g, respectively were studied. Six were sham-operated age-matched controls and 8 adrenal demedullated.The bilateral adrenal demedullation surgery was adapted from Griffith and Farris (1942) and Borkowski and Quinn (1983). The rats were given distilled water postoperatively. All postoperative SHRs were given supplemental heat until they regained consciousness and were able to maintain normal posture. Indirect systolic blood pressure (SBP) was measured by tail cuff method at 1 week and 2 weeks postoperatively. The mean preoperative SBP in control and tested group were 168.78 + 5.80 and 163.15 + 16.26 mmHg respectively. The mean postoperative SBP at 1 week were 170.00 + 9.61 and 128.31 + 19.36 mmHg respectively (p values of 0.753 and 0.012, Wilcoxon Signed Ranks Test- compared to preoperative mean values). The mean postoperative SBP at 2 weeks were 170.50 + 6.22 and 129.00 + 13.34 mmHg respectively (p values of 0.92 and 0.028). Comparison between adrenal demedullated groups and control group SBP show significant SBP difference, at 1 week (p values of 0.005 Mann-Whitney U) and 2 weeks respectively, (p values 0.004). Ad libitum distilled water supplementation and an improved postoperative care allows a sustained normal mean SBP following demedullation in SHRs. 2011-09-11 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/10182/2/Chronic_blood_pressure.pdf Mohd Noor, Noriah and Abdullah, Aszrin and Abdul Razak, Tariq (2011) An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats. In: The 7th Congress of the Federation of Asian and Oceanian Physiological societies., 11-14 September 2011, Taipei, Taiwan. http://faops.org.my/site/index.php
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mohd Noor, Noriah
Abdullah, Aszrin
Abdul Razak, Tariq
An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats
description Adrenal demedullation in young adult, spontaneously hypertensive rats( SHRs) results in blood pressure reduction. However, inconsistent postoperative care of demedullated animals may results in indifferent study findings. The study aims to determine whether an improved method could prevent elevation of blood pressure in young adult SHRs. Fourteen young male and female SHRs weighing 200-270g and 150-170g, respectively were studied. Six were sham-operated age-matched controls and 8 adrenal demedullated.The bilateral adrenal demedullation surgery was adapted from Griffith and Farris (1942) and Borkowski and Quinn (1983). The rats were given distilled water postoperatively. All postoperative SHRs were given supplemental heat until they regained consciousness and were able to maintain normal posture. Indirect systolic blood pressure (SBP) was measured by tail cuff method at 1 week and 2 weeks postoperatively. The mean preoperative SBP in control and tested group were 168.78 + 5.80 and 163.15 + 16.26 mmHg respectively. The mean postoperative SBP at 1 week were 170.00 + 9.61 and 128.31 + 19.36 mmHg respectively (p values of 0.753 and 0.012, Wilcoxon Signed Ranks Test- compared to preoperative mean values). The mean postoperative SBP at 2 weeks were 170.50 + 6.22 and 129.00 + 13.34 mmHg respectively (p values of 0.92 and 0.028). Comparison between adrenal demedullated groups and control group SBP show significant SBP difference, at 1 week (p values of 0.005 Mann-Whitney U) and 2 weeks respectively, (p values 0.004). Ad libitum distilled water supplementation and an improved postoperative care allows a sustained normal mean SBP following demedullation in SHRs.
format Conference or Workshop Item
author Mohd Noor, Noriah
Abdullah, Aszrin
Abdul Razak, Tariq
author_facet Mohd Noor, Noriah
Abdullah, Aszrin
Abdul Razak, Tariq
author_sort Mohd Noor, Noriah
title An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats
title_short An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats
title_full An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats
title_fullStr An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats
title_full_unstemmed An improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats
title_sort improved method for achieving chronic blood pressure reduction following bilateral adrenal demedullation of young hypertensive rats
publishDate 2011
url http://irep.iium.edu.my/10182/
http://irep.iium.edu.my/10182/
http://irep.iium.edu.my/10182/2/Chronic_blood_pressure.pdf
first_indexed 2023-09-18T20:19:37Z
last_indexed 2023-09-18T20:19:37Z
_version_ 1777408018789433344

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