Role of catecholamines in young adults with essential hypertension

Background: Hypertension is a major cause of cardiovascular morbidity and mortality worldwide, and blood pressure (BP) control is poor. Adrenaline has been suggested to play a role in the pathogenesis of essential hypertension. Objective: The aim of this study is to ascertain the role of adren...

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Main Authors:	Abdullah, Aszrin, Mohd Shah, Azarisman Shah, Abdul Razak, Tariq, Mohd Noor, Noriah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/10257/ http://irep.iium.edu.my/10257/ http://irep.iium.edu.my/10257/1/ROLE_OF_CATECHOLAMINES_IN_YOUNG_ADULTS_WITH_ESSENTIAL_HYPERTENSION.pdf

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spelling	iium-102572012-02-23T03:15:46Z http://irep.iium.edu.my/10257/ Role of catecholamines in young adults with essential hypertension Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah R Medicine (General) Background: Hypertension is a major cause of cardiovascular morbidity and mortality worldwide, and blood pressure (BP) control is poor. Adrenaline has been suggested to play a role in the pathogenesis of essential hypertension. Objective: The aim of this study is to ascertain the role of adrenaline and noradrenaline (NA) in young pre-hypertensive and mildly hypertensive subjects using standardized and improved methods in patient preparation, blood sample collection and analysis. Methods and Materials: A total of 484 subjects were screened at a primary health care clinic in Kuantan, Malaysia. 91 subjects with systolic and diastolic BP ranges of between 120 - 159 mmHg and 80 - 99 mmHg respectively (pre- and mildly hypertensive groups) and optimally normotensive, age-matched controls between the ages of 20 and 45 were enrolled into a cross-sectional study. Simple demographic data, blood samples for plasma catecholamine and BP were observed. Reversed-phase High Performance Liquid Chromatography with electrochemical detection was used for the determination of plasma catecholamine. Results: The mean age of the subjects were 32.17 ± 6.21 years. In the patient groups, 46.30% had pre-hypertension BP and 53.70% had mild hypertension. Plasma adrenaline, NA and dopamine levels in the patient group (26.58 ± 36.04, 94.43 + 166.54, 52.43 ± 66.62) were significantly greater (p = 0.01, 0.02, 0.02) than age matched-controls with optimally normotensive BP (12.04 ± 9.93, 37.18 + 62.14, 27.06 ± 34.49). Statistically significant differences in plasma adrenaline and dopamine levels were seen between the pre-hypertensive and optimally normotensive BP groups (p=0.002 and p=0.01, respectively). The pre-hypertensive BP group’s plasma adrenaline were also significantly higher than mild hypertension group (p=0.04). Within the patient groups, the mean arterial pressure (MAP) was weakly correlated with plasma adrenaline (r= -0.34, p=0.01), NA (r= -0.28, p=0.04) and dopamine levels (r= -0.29, p=0.04). Conclusion: Our study has shown that there is increased plasma adrenaline in young, pre- and mildly hypertensive subjects. There is also a weak inverse relationship between adrenaline and the MAP. It appears to support adrenaline’s role in the pathogenesis of essential hypertension in very early stages of hypertension development. 2011-01-14 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/10257/1/ROLE_OF_CATECHOLAMINES_IN_YOUNG_ADULTS_WITH_ESSENTIAL_HYPERTENSION.pdf Abdullah, Aszrin and Mohd Shah, Azarisman Shah and Abdul Razak, Tariq and Mohd Noor, Noriah (2011) Role of catecholamines in young adults with essential hypertension. In: The 8th Annual Scientific Meeting, Malaysian Society of Hypertension, 14-16 January 2011, Kuala Lumpur. http://www.msh.my
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah Role of catecholamines in young adults with essential hypertension
description	Background: Hypertension is a major cause of cardiovascular morbidity and mortality worldwide, and blood pressure (BP) control is poor. Adrenaline has been suggested to play a role in the pathogenesis of essential hypertension. Objective: The aim of this study is to ascertain the role of adrenaline and noradrenaline (NA) in young pre-hypertensive and mildly hypertensive subjects using standardized and improved methods in patient preparation, blood sample collection and analysis. Methods and Materials: A total of 484 subjects were screened at a primary health care clinic in Kuantan, Malaysia. 91 subjects with systolic and diastolic BP ranges of between 120 - 159 mmHg and 80 - 99 mmHg respectively (pre- and mildly hypertensive groups) and optimally normotensive, age-matched controls between the ages of 20 and 45 were enrolled into a cross-sectional study. Simple demographic data, blood samples for plasma catecholamine and BP were observed. Reversed-phase High Performance Liquid Chromatography with electrochemical detection was used for the determination of plasma catecholamine. Results: The mean age of the subjects were 32.17 ± 6.21 years. In the patient groups, 46.30% had pre-hypertension BP and 53.70% had mild hypertension. Plasma adrenaline, NA and dopamine levels in the patient group (26.58 ± 36.04, 94.43 + 166.54, 52.43 ± 66.62) were significantly greater (p = 0.01, 0.02, 0.02) than age matched-controls with optimally normotensive BP (12.04 ± 9.93, 37.18 + 62.14, 27.06 ± 34.49). Statistically significant differences in plasma adrenaline and dopamine levels were seen between the pre-hypertensive and optimally normotensive BP groups (p=0.002 and p=0.01, respectively). The pre-hypertensive BP group’s plasma adrenaline were also significantly higher than mild hypertension group (p=0.04). Within the patient groups, the mean arterial pressure (MAP) was weakly correlated with plasma adrenaline (r= -0.34, p=0.01), NA (r= -0.28, p=0.04) and dopamine levels (r= -0.29, p=0.04). Conclusion: Our study has shown that there is increased plasma adrenaline in young, pre- and mildly hypertensive subjects. There is also a weak inverse relationship between adrenaline and the MAP. It appears to support adrenaline’s role in the pathogenesis of essential hypertension in very early stages of hypertension development.
format	Conference or Workshop Item
author	Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah
author_facet	Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah
author_sort	Abdullah, Aszrin
title	Role of catecholamines in young adults with essential hypertension
title_short	Role of catecholamines in young adults with essential hypertension
title_full	Role of catecholamines in young adults with essential hypertension
title_fullStr	Role of catecholamines in young adults with essential hypertension
title_full_unstemmed	Role of catecholamines in young adults with essential hypertension
title_sort	role of catecholamines in young adults with essential hypertension
publishDate	2011
url	http://irep.iium.edu.my/10257/ http://irep.iium.edu.my/10257/ http://irep.iium.edu.my/10257/1/ROLE_OF_CATECHOLAMINES_IN_YOUNG_ADULTS_WITH_ESSENTIAL_HYPERTENSION.pdf
first_indexed	2023-09-18T20:19:40Z
last_indexed	2023-09-18T20:19:40Z
_version_	1777408022654484480

Role of catecholamines in young adults with essential hypertension

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