Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study

Background: Hypertension is one of the most important risk factors for Cardiovascular Disease in Malaysia. Hypertension prevalence in Malaysia is at 42.6% based on the 2006 National Health and Morbidity Survey and population-based hypertension control is extremely poor at only 26.8%. Objective:...

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Main Authors:	Abdullah, Aszrin, Mohd Shah, Azarisman Shah, Abdul Razak, Tariq, Mohd Noor, Noriah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/10281/ http://irep.iium.edu.my/10281/ http://irep.iium.edu.my/10281/1/BIOCHEMICAL_PROFILE_OF_YOUNG_PRE.pdf

id	iium-10281
recordtype	eprints
spelling	iium-102812012-02-23T08:29:29Z http://irep.iium.edu.my/10281/ Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah R Medicine (General) Background: Hypertension is one of the most important risk factors for Cardiovascular Disease in Malaysia. Hypertension prevalence in Malaysia is at 42.6% based on the 2006 National Health and Morbidity Survey and population-based hypertension control is extremely poor at only 26.8%. Objective: The objective of the study is to ascertain the biochemical profile of young pre-hypertensive and mildly hypertensive adults against age-matched, optimally normotensive controls in a single centre in Kuantan, Pahang. Methods and Materials: 484 subjects attending a primary health care clinic in Kuantan were screened. 91 young adults between the ages of 20 and 45 with systolic (SBP) and diastolic (DBP) blood pressure (BP) ranges of between 120 - 159 mmHg and 80 - 99 mmHg respectively and age-matched controls were enrolled in a cross-sectional study. The BP and biochemical profiles were assessed and compared. Results: The mean age of the subjects were 32.17 ± 6.21 years. In the patient groups, 46.30% had pre-hypertension BP and 53.70% had mild hypertension. Mean values of subjects in the patient and age-matched control groups for total cholesterol (TC) 5.82 ± 1.03 vs 5.51 ± 1.03 (p=0.16), low-density lipoprotein cholesterol (LDL) 3.75 ± 0.95 vs 3.32 ± 0.93 (p=0.03), high-density lipoprotein cholesterol (HDL) 1.33 + 0.35 vs 1.73 + 0.46 (p< 0.001), triglyceride 1.68 + 0.88 vs 1.01 + 0.54 (p< 0.001), TC/HDL ratio 4.58 ± 1.16 vs 3.34 ± 0.98 (p< 0.001), fasting blood glucose (FBG) 4.65 ± 0.54 vs 4.33 ± 0.42 (p=0.03) and body mass index (BMI) 28.81 ± 5.16 vs 24.12 ± 4.91 (p< 0.001). Pre-hypertensive and mildly hypertensive group subjects both had statistically significant higher HDL (p< 0.001), triglyceride (p< 0.001), TC/HDL ratio (p< 0.001), FBG (p= 0.001) and BMI (p< 0.001) compared to optimally normotensive controls. The mean BP (SBP, DBP) of subjects was significantly associated with BMI, FBG, triglycerides, HDL and the TC/HDL ratio. Conclusion: Greater BMI, FBG, HDL, triglyceride levels and TC/HDL ratio significantly characterised the young adults with pre-hypertension and mild hypertension. The data suggests that essential hypertension, in young adults especially, rather than being a standalone cause, is an accumulation of several clinical abnormalities befitting metabolic syndrome instead. 2011-01-14 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/10281/1/BIOCHEMICAL_PROFILE_OF_YOUNG_PRE.pdf Abdullah, Aszrin and Mohd Shah, Azarisman Shah and Abdul Razak, Tariq and Mohd Noor, Noriah (2011) Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study. In: The 8th Annual Scientific Meeting, Malaysian Society Of Hypertension, 14-16 January 2011, Kuala Lumpur. http://www.msh.my
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study
description	Background: Hypertension is one of the most important risk factors for Cardiovascular Disease in Malaysia. Hypertension prevalence in Malaysia is at 42.6% based on the 2006 National Health and Morbidity Survey and population-based hypertension control is extremely poor at only 26.8%. Objective: The objective of the study is to ascertain the biochemical profile of young pre-hypertensive and mildly hypertensive adults against age-matched, optimally normotensive controls in a single centre in Kuantan, Pahang. Methods and Materials: 484 subjects attending a primary health care clinic in Kuantan were screened. 91 young adults between the ages of 20 and 45 with systolic (SBP) and diastolic (DBP) blood pressure (BP) ranges of between 120 - 159 mmHg and 80 - 99 mmHg respectively and age-matched controls were enrolled in a cross-sectional study. The BP and biochemical profiles were assessed and compared. Results: The mean age of the subjects were 32.17 ± 6.21 years. In the patient groups, 46.30% had pre-hypertension BP and 53.70% had mild hypertension. Mean values of subjects in the patient and age-matched control groups for total cholesterol (TC) 5.82 ± 1.03 vs 5.51 ± 1.03 (p=0.16), low-density lipoprotein cholesterol (LDL) 3.75 ± 0.95 vs 3.32 ± 0.93 (p=0.03), high-density lipoprotein cholesterol (HDL) 1.33 + 0.35 vs 1.73 + 0.46 (p< 0.001), triglyceride 1.68 + 0.88 vs 1.01 + 0.54 (p< 0.001), TC/HDL ratio 4.58 ± 1.16 vs 3.34 ± 0.98 (p< 0.001), fasting blood glucose (FBG) 4.65 ± 0.54 vs 4.33 ± 0.42 (p=0.03) and body mass index (BMI) 28.81 ± 5.16 vs 24.12 ± 4.91 (p< 0.001). Pre-hypertensive and mildly hypertensive group subjects both had statistically significant higher HDL (p< 0.001), triglyceride (p< 0.001), TC/HDL ratio (p< 0.001), FBG (p= 0.001) and BMI (p< 0.001) compared to optimally normotensive controls. The mean BP (SBP, DBP) of subjects was significantly associated with BMI, FBG, triglycerides, HDL and the TC/HDL ratio. Conclusion: Greater BMI, FBG, HDL, triglyceride levels and TC/HDL ratio significantly characterised the young adults with pre-hypertension and mild hypertension. The data suggests that essential hypertension, in young adults especially, rather than being a standalone cause, is an accumulation of several clinical abnormalities befitting metabolic syndrome instead.
format	Conference or Workshop Item
author	Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah
author_facet	Abdullah, Aszrin Mohd Shah, Azarisman Shah Abdul Razak, Tariq Mohd Noor, Noriah
author_sort	Abdullah, Aszrin
title	Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study
title_short	Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study
title_full	Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study
title_fullStr	Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study
title_full_unstemmed	Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study
title_sort	biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study
publishDate	2011
url	http://irep.iium.edu.my/10281/ http://irep.iium.edu.my/10281/ http://irep.iium.edu.my/10281/1/BIOCHEMICAL_PROFILE_OF_YOUNG_PRE.pdf
first_indexed	2023-09-18T20:19:42Z
last_indexed	2023-09-18T20:19:42Z
_version_	1777408024091033600

Biochemical profile of young pre- and mildly hypertensive adults: a single centre, case control study

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