Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report

Metastatic spread of tumors to the skull is quite unusual and often represents diagnostic and therapeutic issues. Skull involvement can be observed in various neoplasms of epithelial origin and are most often due to lung, breast, thyroid, kidney and prostate cancers. However, skull metastases from h...

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Main Authors:	Muhammed Nordin, Ellyda, Abdullah, Mohd Shafie
Format:	Article
Language:	English
Published:	Kulliyyah of Medicine, International Islamic University Malaysia 2009
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/10330/ http://irep.iium.edu.my/10330/ http://irep.iium.edu.my/10330/1/IMJVol8No2pg47-52.pdf

id	iium-10330
recordtype	eprints
spelling	iium-103302012-01-19T03:20:55Z http://irep.iium.edu.my/10330/ Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report Muhammed Nordin, Ellyda Abdullah, Mohd Shafie R Medicine (General) Metastatic spread of tumors to the skull is quite unusual and often represents diagnostic and therapeutic issues. Skull involvement can be observed in various neoplasms of epithelial origin and are most often due to lung, breast, thyroid, kidney and prostate cancers. However, skull metastases from hepatocellular carcinoma (HCC) have been rarely reported. The prognosis for patients with hepatocellular carcinoma is so poor that treatment of such distant metastatic lesion cannot be achieved before death occurs due to the primary malignancy. Therefore, the clinical manifestations of cranial metastasis prior to that of primary hepatocellular carcinoma have rarely been reported. This case illustrates a rare case of skull metastasis as an initial manifestation of hepatocellular carcinoma. Although a solitary skull metastasis prior to the diagnosis of HCC demonstrates rare metastatic behavior for HCC, especially in Asia, skull metastases from HCC should be included in the differential diagnosis of skull tumors, even if the patient is asymptomatic of liver cirrhosis. Kulliyyah of Medicine, International Islamic University Malaysia 2009-12-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/10330/1/IMJVol8No2pg47-52.pdf Muhammed Nordin, Ellyda and Abdullah, Mohd Shafie (2009) Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report. International Medical Journal Malaysia, 8 (2). pp. 47-50. ISSN 1823-4631 http://www.e-imj.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Muhammed Nordin, Ellyda Abdullah, Mohd Shafie Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
description	Metastatic spread of tumors to the skull is quite unusual and often represents diagnostic and therapeutic issues. Skull involvement can be observed in various neoplasms of epithelial origin and are most often due to lung, breast, thyroid, kidney and prostate cancers. However, skull metastases from hepatocellular carcinoma (HCC) have been rarely reported. The prognosis for patients with hepatocellular carcinoma is so poor that treatment of such distant metastatic lesion cannot be achieved before death occurs due to the primary malignancy. Therefore, the clinical manifestations of cranial metastasis prior to that of primary hepatocellular carcinoma have rarely been reported. This case illustrates a rare case of skull metastasis as an initial manifestation of hepatocellular carcinoma. Although a solitary skull metastasis prior to the diagnosis of HCC demonstrates rare metastatic behavior for HCC, especially in Asia, skull metastases from HCC should be included in the differential diagnosis of skull tumors, even if the patient is asymptomatic of liver cirrhosis.
format	Article
author	Muhammed Nordin, Ellyda Abdullah, Mohd Shafie
author_facet	Muhammed Nordin, Ellyda Abdullah, Mohd Shafie
author_sort	Muhammed Nordin, Ellyda
title	Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_short	Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_full	Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_fullStr	Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_full_unstemmed	Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
title_sort	solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report
publisher	Kulliyyah of Medicine, International Islamic University Malaysia
publishDate	2009
url	http://irep.iium.edu.my/10330/ http://irep.iium.edu.my/10330/ http://irep.iium.edu.my/10330/1/IMJVol8No2pg47-52.pdf
first_indexed	2023-09-18T20:19:46Z
last_indexed	2023-09-18T20:19:46Z
_version_	1777408028940697600

Solitary skull metastasis as initial manifestation of hepatocellular carcinoma – a case report

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