Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis

A capillary zone electrophoresis (CZE) method for the simultaneous determination of the β-blocker drugs atenolol and chlorthalidone in pharmaceutical formulations has been developed. The CZE separation was performed under the following conditions: capillary temperature, 25°C; applied voltage, 25 kV;...

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Main Authors:	Khaldun, Al-Azzam, Elbashir, Abdalla A., Elbashir,, Mohammed A, Saad, Bahruddin, Abd Hamid, Shafida
Format:	Article
Language:	English
Published:	Taylor & Francis Inc. 2009
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/10561/ http://irep.iium.edu.my/10561/ http://irep.iium.edu.my/10561/ http://irep.iium.edu.my/10561/4/Analytical_Letters.pdf

id	iium-10561
recordtype	eprints
spelling	iium-105612012-02-07T23:44:24Z http://irep.iium.edu.my/10561/ Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis Khaldun, Al-Azzam Elbashir, Abdalla A. Elbashir,, Mohammed A Saad, Bahruddin Abd Hamid, Shafida QD Chemistry A capillary zone electrophoresis (CZE) method for the simultaneous determination of the β-blocker drugs atenolol and chlorthalidone in pharmaceutical formulations has been developed. The CZE separation was performed under the following conditions: capillary temperature, 25°C; applied voltage, 25 kV; 20 mM H3PO4–NaOH running buffer (pH 9.0); and detection wavelength, 198 nm. Phenobarbital was used as internal standard. The method was validated and showed not only good precision and accuracy but also good robustness. The method has been successfully applied to the simultaneous determination of both atenolol and chlorthalidone in pharmaceutical tablets. Taylor & Francis Inc. 2009 Article PeerReviewed application/pdf en http://irep.iium.edu.my/10561/4/Analytical_Letters.pdf Khaldun, Al-Azzam and Elbashir, Abdalla A. and Elbashir,, Mohammed A and Saad, Bahruddin and Abd Hamid, Shafida (2009) Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis. Analytical letters, 42 (10). pp. 1458-1470. ISSN 0003-2719 http://www.tandfonline.com/doi/abs/10.1080/00032710902961065 10.1080/00032710902961065
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Khaldun, Al-Azzam Elbashir, Abdalla A. Elbashir,, Mohammed A Saad, Bahruddin Abd Hamid, Shafida Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis
description	A capillary zone electrophoresis (CZE) method for the simultaneous determination of the β-blocker drugs atenolol and chlorthalidone in pharmaceutical formulations has been developed. The CZE separation was performed under the following conditions: capillary temperature, 25°C; applied voltage, 25 kV; 20 mM H3PO4–NaOH running buffer (pH 9.0); and detection wavelength, 198 nm. Phenobarbital was used as internal standard. The method was validated and showed not only good precision and accuracy but also good robustness. The method has been successfully applied to the simultaneous determination of both atenolol and chlorthalidone in pharmaceutical tablets.
format	Article
author	Khaldun, Al-Azzam Elbashir, Abdalla A. Elbashir,, Mohammed A Saad, Bahruddin Abd Hamid, Shafida
author_facet	Khaldun, Al-Azzam Elbashir, Abdalla A. Elbashir,, Mohammed A Saad, Bahruddin Abd Hamid, Shafida
author_sort	Khaldun, Al-Azzam
title	Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis
title_short	Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis
title_full	Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis
title_fullStr	Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis
title_full_unstemmed	Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis
title_sort	simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis
publisher	Taylor & Francis Inc.
publishDate	2009
url	http://irep.iium.edu.my/10561/ http://irep.iium.edu.my/10561/ http://irep.iium.edu.my/10561/ http://irep.iium.edu.my/10561/4/Analytical_Letters.pdf
first_indexed	2023-09-18T20:19:58Z
last_indexed	2023-09-18T20:19:58Z
_version_	1777408040785412096

Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis

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