The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats

Adrenaline plays a role in the pathogenesis of essential hypertension through excessive stimulation of adrenomedullary hormonal system. Pharmacological inhibition of adrenomedullary hormonal system should result in chronic, sustained blood pressure(BP) reduction. We propose the use of 1,2,3,4-tetr...

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Main Authors:	Abdullah, Aszrin, Abdul Razak, Tariq, Mohd Noor, Noriah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/10564/ http://irep.iium.edu.my/10564/ http://irep.iium.edu.my/10564/1/PNMT1_bandung.doc

id	iium-10564
recordtype	eprints
spelling	iium-105642012-02-23T03:28:51Z http://irep.iium.edu.my/10564/ The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats Abdullah, Aszrin Abdul Razak, Tariq Mohd Noor, Noriah R Medicine (General) Adrenaline plays a role in the pathogenesis of essential hypertension through excessive stimulation of adrenomedullary hormonal system. Pharmacological inhibition of adrenomedullary hormonal system should result in chronic, sustained blood pressure(BP) reduction. We propose the use of 1,2,3,4-tetrahydroisoquinolines (THIQ) as a phenylethanolamine N-methyltransferase (PNMT) inhibitor in young spontaneously hypertensive rats will result in sustained BP reduction. 14 young male and female SHRs weighing between 160 and 270g were studied. Eight study rats administered with daily THIQ (Treated) and 6 age-matched controls (Control) were included. Indirect systolic blood pressure (SBP) was measured by tail cuff method prior to drug study (baseline), 2-hours post-administration on D1, D3 (subchronic), D7 and D14. The mean baseline SBP in Treated and Control SHRs were 163.15 + 16.26 vs 171.69 + 17.27 mmHg respectively (p=1.00). The mean SBP at D7 were 128.31 + 19.36 vs 173.06 + 19.62 mmHg respectively (p=0.035). The mean SBP at D14 were 129.00 + 13.34 vs 180.08 + 14.59 mmHg respectively (p=0.041). There was no significant difference in the mean weight and age of the two groups throughout the study duration. Chronic 1,2,3,4-tetrahydroisoquinolines administration is an effective inhibitor of phenylethanolamine N-methyl transferase, the enzyme that catalyzes the terminal step in the biosynthesis of adrenaline, thereby resulting in sustained BP reduction in young spontaneously hypertensive rats. 2011-06-16 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/10564/1/PNMT1_bandung.doc Abdullah, Aszrin and Abdul Razak, Tariq and Mohd Noor, Noriah (2011) The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats. In: 5th Conference of Asian Association Of School Of Pharmacy, 16-19 June 2011, Bandung. http://www.aasp2011.fa.itb.ac.id
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Abdullah, Aszrin Abdul Razak, Tariq Mohd Noor, Noriah The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats
description	Adrenaline plays a role in the pathogenesis of essential hypertension through excessive stimulation of adrenomedullary hormonal system. Pharmacological inhibition of adrenomedullary hormonal system should result in chronic, sustained blood pressure(BP) reduction. We propose the use of 1,2,3,4-tetrahydroisoquinolines (THIQ) as a phenylethanolamine N-methyltransferase (PNMT) inhibitor in young spontaneously hypertensive rats will result in sustained BP reduction. 14 young male and female SHRs weighing between 160 and 270g were studied. Eight study rats administered with daily THIQ (Treated) and 6 age-matched controls (Control) were included. Indirect systolic blood pressure (SBP) was measured by tail cuff method prior to drug study (baseline), 2-hours post-administration on D1, D3 (subchronic), D7 and D14. The mean baseline SBP in Treated and Control SHRs were 163.15 + 16.26 vs 171.69 + 17.27 mmHg respectively (p=1.00). The mean SBP at D7 were 128.31 + 19.36 vs 173.06 + 19.62 mmHg respectively (p=0.035). The mean SBP at D14 were 129.00 + 13.34 vs 180.08 + 14.59 mmHg respectively (p=0.041). There was no significant difference in the mean weight and age of the two groups throughout the study duration. Chronic 1,2,3,4-tetrahydroisoquinolines administration is an effective inhibitor of phenylethanolamine N-methyl transferase, the enzyme that catalyzes the terminal step in the biosynthesis of adrenaline, thereby resulting in sustained BP reduction in young spontaneously hypertensive rats.
format	Conference or Workshop Item
author	Abdullah, Aszrin Abdul Razak, Tariq Mohd Noor, Noriah
author_facet	Abdullah, Aszrin Abdul Razak, Tariq Mohd Noor, Noriah
author_sort	Abdullah, Aszrin
title	The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats
title_short	The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats
title_full	The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats
title_fullStr	The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats
title_full_unstemmed	The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats
title_sort	effect of chronic 1,2,3,4-tetrahydroisoquinolines administration in young spontaneously hypertensive rats
publishDate	2011
url	http://irep.iium.edu.my/10564/ http://irep.iium.edu.my/10564/ http://irep.iium.edu.my/10564/1/PNMT1_bandung.doc
first_indexed	2023-09-18T20:19:58Z
last_indexed	2023-09-18T20:19:58Z
_version_	1777408041077964800

The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats

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