New considerations in the design of clinical trials of acute kidney injury

Acute kidney injury is a common and frequently fatal disease without an effective early intervention. The translation of promising experimental treatments to effective clinical trials has been hampered by the lack of a means to detect acute kidney injury early. Novel biomarkers of kidney injury...

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Main Authors:	Md Ralib, Azrina, Pickering, John W., Nejat, Maryam, Endre, Zoltan H.
Format:	Article
Language:	English
Published:	Future Science 2011
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/10620/ http://irep.iium.edu.my/10620/ http://irep.iium.edu.my/10620/1/Clinical_Investigation_2011_Pickering.pdf

id	iium-10620
recordtype	eprints
spelling	iium-106202012-01-27T08:00:22Z http://irep.iium.edu.my/10620/ New considerations in the design of clinical trials of acute kidney injury Md Ralib, Azrina Pickering, John W. Nejat, Maryam Endre, Zoltan H. R Medicine (General) Acute kidney injury is a common and frequently fatal disease without an effective early intervention. The translation of promising experimental treatments to effective clinical trials has been hampered by the lack of a means to detect acute kidney injury early. Novel biomarkers of kidney injury have made early intervention possible and the first early intervention trial has been run. Emerging issues are the timing of biomarker measurement, the relationship of biomarker concentration with baseline renal function, and determining a primary outcome that best reflects renal function. A new generation of early intervention trials with increased prospects of finding effective therapies are now possible utilizing currently available novel biomarkers. Proposed new outcome measures will decrease the likelihood of negative trials as a result of poor design. Future Science 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/10620/1/Clinical_Investigation_2011_Pickering.pdf Md Ralib, Azrina and Pickering, John W. and Nejat, Maryam and Endre, Zoltan H. (2011) New considerations in the design of clinical trials of acute kidney injury. Clinical Investigation, 1 (5). pp. 637-650. ISSN 2041-6792 http://www.future-science.com/loi/cli
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Md Ralib, Azrina Pickering, John W. Nejat, Maryam Endre, Zoltan H. New considerations in the design of clinical trials of acute kidney injury
description	Acute kidney injury is a common and frequently fatal disease without an effective early intervention. The translation of promising experimental treatments to effective clinical trials has been hampered by the lack of a means to detect acute kidney injury early. Novel biomarkers of kidney injury have made early intervention possible and the first early intervention trial has been run. Emerging issues are the timing of biomarker measurement, the relationship of biomarker concentration with baseline renal function, and determining a primary outcome that best reflects renal function. A new generation of early intervention trials with increased prospects of finding effective therapies are now possible utilizing currently available novel biomarkers. Proposed new outcome measures will decrease the likelihood of negative trials as a result of poor design.
format	Article
author	Md Ralib, Azrina Pickering, John W. Nejat, Maryam Endre, Zoltan H.
author_facet	Md Ralib, Azrina Pickering, John W. Nejat, Maryam Endre, Zoltan H.
author_sort	Md Ralib, Azrina
title	New considerations in the design of clinical trials of acute kidney injury
title_short	New considerations in the design of clinical trials of acute kidney injury
title_full	New considerations in the design of clinical trials of acute kidney injury
title_fullStr	New considerations in the design of clinical trials of acute kidney injury
title_full_unstemmed	New considerations in the design of clinical trials of acute kidney injury
title_sort	new considerations in the design of clinical trials of acute kidney injury
publisher	Future Science
publishDate	2011
url	http://irep.iium.edu.my/10620/ http://irep.iium.edu.my/10620/ http://irep.iium.edu.my/10620/1/Clinical_Investigation_2011_Pickering.pdf
first_indexed	2023-09-18T20:20:01Z
last_indexed	2023-09-18T20:20:01Z
_version_	1777408043994054656

New considerations in the design of clinical trials of acute kidney injury

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