Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone

Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone

Introduction: Critical size defect (CSD) is defined as a defect that will not heal without intervention within the lifetime. The gold standard treatment for CSD is bone graft, although with some limitations. Substitute biomaterials were introduced to overcome the limitations. JectOS and MIIG® X3 are...

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Main Authors: Wan Salleh, Wan Maihan, Mohamed Amin, Mohamed Azril, Wan Salleh, Wan Salahuddin, Buyong, Zunariah
Format: Article
Language:English
Published: Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2016
Subjects:
R Medicine (General)
RD701 Orthopedics
Online Access:http://irep.iium.edu.my/11292/
http://irep.iium.edu.my/11292/
http://irep.iium.edu.my/11292/1/Proceeding%20IMJM%20Vol%2015%20Supp.%20pp%2060%20Comparison%20of%20ex-vivo%20x-ray%20changes%20in%20different%20groups%20of%20injectable%20biomaterials%20%28JectOS%2C%20MIIG%C2%AEX3%2C%20Osteopaste%29.pdf
id iium-11292
recordtype eprints
spelling iium-112922019-01-10T08:03:04Z http://irep.iium.edu.my/11292/ Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone Wan Salleh, Wan Maihan Mohamed Amin, Mohamed Azril Wan Salleh, Wan Salahuddin Buyong, Zunariah R Medicine (General) RD701 Orthopedics Introduction: Critical size defect (CSD) is defined as a defect that will not heal without intervention within the lifetime. The gold standard treatment for CSD is bone graft, although with some limitations. Substitute biomaterials were introduced to overcome the limitations. JectOS and MIIG® X3 are commercially available biomaterials in the market. Osteopaste is a local product produced by SIRIM. The objective of this study is to compare the radiological changes between Osteopaste, JectOS and MIIG® X3 in CSD in rabbit tibia bone. Methods: New Zealand White rabbits were divided into four groups: control group (Sham operation, n=3); Osteopaste treatment (n=12); JectOS treatment (n=12) and MIIG® X3 treatment (n=12). CSD was created at the right proximal tibia bone of the rabbits in each of the groups and the defects were filled with the biomaterial as assigned. Four animals from each group were sacrificed at 6 weeks, 12 weeks and 24 weeks respectively. The bones were harvested and x-ray imaging performed using SkyScan 1176 at 90kV, 281µA, resolution 4000x2672 with Aluminium 1.0mm. Results: The radiographic density at the CSD area was more prominent in the JectOS group throughout the 24 weeks. Meanwhile, in the MIIG® X3, full resorption occurred at 24 weeks. The Osteopaste group exhibited radiographic density in between that of JectOS and MIIG® X3. Conclusions: Different types of biomaterial exhibit different radiological changes over the period of bone healing. KEYWORDS: critical size defect, osteopaste, bone biomaterial Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2016-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11292/1/Proceeding%20IMJM%20Vol%2015%20Supp.%20pp%2060%20Comparison%20of%20ex-vivo%20x-ray%20changes%20in%20different%20groups%20of%20injectable%20biomaterials%20%28JectOS%2C%20MIIG%C2%AEX3%2C%20Osteopaste%29.pdf Wan Salleh, Wan Maihan and Mohamed Amin, Mohamed Azril and Wan Salleh, Wan Salahuddin and Buyong, Zunariah (2016) Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone. The International Medical Journal Malaysia, 15 (Supplementary Issue). p. 60. ISSN 1823-4631 http://iiumedic.net/imjm/v1/
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
RD701 Orthopedics
spellingShingle R Medicine (General)
RD701 Orthopedics
Wan Salleh, Wan Maihan
Mohamed Amin, Mohamed Azril
Wan Salleh, Wan Salahuddin
Buyong, Zunariah
Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone
description Introduction: Critical size defect (CSD) is defined as a defect that will not heal without intervention within the lifetime. The gold standard treatment for CSD is bone graft, although with some limitations. Substitute biomaterials were introduced to overcome the limitations. JectOS and MIIG® X3 are commercially available biomaterials in the market. Osteopaste is a local product produced by SIRIM. The objective of this study is to compare the radiological changes between Osteopaste, JectOS and MIIG® X3 in CSD in rabbit tibia bone. Methods: New Zealand White rabbits were divided into four groups: control group (Sham operation, n=3); Osteopaste treatment (n=12); JectOS treatment (n=12) and MIIG® X3 treatment (n=12). CSD was created at the right proximal tibia bone of the rabbits in each of the groups and the defects were filled with the biomaterial as assigned. Four animals from each group were sacrificed at 6 weeks, 12 weeks and 24 weeks respectively. The bones were harvested and x-ray imaging performed using SkyScan 1176 at 90kV, 281µA, resolution 4000x2672 with Aluminium 1.0mm. Results: The radiographic density at the CSD area was more prominent in the JectOS group throughout the 24 weeks. Meanwhile, in the MIIG® X3, full resorption occurred at 24 weeks. The Osteopaste group exhibited radiographic density in between that of JectOS and MIIG® X3. Conclusions: Different types of biomaterial exhibit different radiological changes over the period of bone healing. KEYWORDS: critical size defect, osteopaste, bone biomaterial
format Article
author Wan Salleh, Wan Maihan
Mohamed Amin, Mohamed Azril
Wan Salleh, Wan Salahuddin
Buyong, Zunariah
author_facet Wan Salleh, Wan Maihan
Mohamed Amin, Mohamed Azril
Wan Salleh, Wan Salahuddin
Buyong, Zunariah
author_sort Wan Salleh, Wan Maihan
title Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone
title_short Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone
title_full Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone
title_fullStr Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone
title_full_unstemmed Comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (JectOS, MIIG®X3, Osteopaste) in critical size defect of rabbit tibia bone
title_sort comparison of ex-vivo x-ray changes in different groups of injectable biomaterials (jectos, miig®x3, osteopaste) in critical size defect of rabbit tibia bone
publisher Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate 2016
url http://irep.iium.edu.my/11292/
http://irep.iium.edu.my/11292/
http://irep.iium.edu.my/11292/1/Proceeding%20IMJM%20Vol%2015%20Supp.%20pp%2060%20Comparison%20of%20ex-vivo%20x-ray%20changes%20in%20different%20groups%20of%20injectable%20biomaterials%20%28JectOS%2C%20MIIG%C2%AEX3%2C%20Osteopaste%29.pdf
first_indexed 2023-09-18T20:20:37Z
last_indexed 2023-09-18T20:20:37Z
_version_ 1777408082146492416

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