In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding

Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of 18.2 microM. The IC 50 values of m...

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Main Authors:	Jantan, Ibrahim, Md Pisar, Mazura, Idris, Muhammad Sum, Bakhtiar, M. Taher, Mat Ali, Rasadah
Format:	Article
Language:	English
Published:	Thieme Verlagsgruppe 2002
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/12052/ http://irep.iium.edu.my/12052/ http://irep.iium.edu.my/12052/1/Plantamedica.pdf

id	iium-12052
recordtype	eprints
spelling	iium-120522014-12-09T00:29:00Z http://irep.iium.edu.my/12052/ In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah RS Pharmacy and materia medica Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of 18.2 microM. The IC 50 values of macluraxanthone, 6-deoxyjacareubin, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone, 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone and 1,3,5-trihydroxy-6,6'-dimethylpyrano(2',3':6,7)-4-(1,1-dimethylprop-2-enyl)-xanthone were also determined for comparison. In the course of our study on structure-activity relationship of xanthones, the results revealed that a geranyl group substituted at C-8 was beneficial to the binding while a hydroxylated prenyl group at C-4 resulted in a significant loss in binding to the PAF receptor. Thieme Verlagsgruppe 2002 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12052/1/Plantamedica.pdf Jantan, Ibrahim and Md Pisar, Mazura and Idris, Muhammad Sum and Bakhtiar, M. Taher and Mat Ali, Rasadah (2002) In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding. Planta Medica, 68. pp. 1133-1134. ISSN 0032-0943 http://www.thieme.de/plantamedica/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding
description	Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of 18.2 microM. The IC 50 values of macluraxanthone, 6-deoxyjacareubin, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone, 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone and 1,3,5-trihydroxy-6,6'-dimethylpyrano(2',3':6,7)-4-(1,1-dimethylprop-2-enyl)-xanthone were also determined for comparison. In the course of our study on structure-activity relationship of xanthones, the results revealed that a geranyl group substituted at C-8 was beneficial to the binding while a hydroxylated prenyl group at C-4 resulted in a significant loss in binding to the PAF receptor.
format	Article
author	Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah
author_facet	Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah
author_sort	Jantan, Ibrahim
title	In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding
title_short	In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding
title_full	In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding
title_fullStr	In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding
title_full_unstemmed	In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding
title_sort	in vitro inhibitory effect of rubraxanthone isolated from garcinia psrvifolia on platelet- activating factor receptor binding
publisher	Thieme Verlagsgruppe
publishDate	2002
url	http://irep.iium.edu.my/12052/ http://irep.iium.edu.my/12052/ http://irep.iium.edu.my/12052/1/Plantamedica.pdf
first_indexed	2023-09-18T20:21:16Z
last_indexed	2023-09-18T20:21:16Z
_version_	1777408122601603072

In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding

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