A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes

Non-insulin-dependent diabetes mellitus is due to in large part to insulin resistance, a state where the target cells are no longer responding to ordinary levels of circulating insulin. A drug that promotes the initiation of insulin receptor (IR) signaling by enhancing IR phosphorylation should be...

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Main Authors:	Bakhtiar, M. Taher, Fadzilah Adibah, Abdul Majid, Mohamad Roji, Sarmidi
Format:	Article
Language:	English
Published:	Penerbit UTM 2006
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/12067/ http://irep.iium.edu.my/12067/ http://irep.iium.edu.my/12067/ http://irep.iium.edu.my/12067/1/JTF_Taher.pdf

id	iium-12067
recordtype	eprints
spelling	iium-120672014-12-09T00:28:11Z http://irep.iium.edu.my/12067/ A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes Bakhtiar, M. Taher Fadzilah Adibah, Abdul Majid Mohamad Roji, Sarmidi RS Pharmacy and materia medica Non-insulin-dependent diabetes mellitus is due to in large part to insulin resistance, a state where the target cells are no longer responding to ordinary levels of circulating insulin. A drug that promotes the initiation of insulin receptor (IR) signaling by enhancing IR phosphorylation should be useful in the treatment of Type 2 diabetes. To investigate a compound that is able to phosphorylate IR, a proanthocyanidin, cinnamtannin B1, has been isolated from the stem bark of Cinnamomum zeylanicum Blume (Lauraceae). The structure of the compound was established by spectroscopic methods. Cinnamtannin B1 (0.11 mM) activates the phosphorylation of insulin receptor β-subunit on 3T3-L1 adipocytes. Like insulin, cinnamtannin B1-stimulated phosphorylation of insulin receptor was inhibited by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) and cytochalasin B, an inhibitor of the glucose transporter (GLUT4); otherwise the phosphorylation was enhanced by vanadate, a tyrosine phosphatase inhibitor. These results suggest that the activity of cinnamtannin B1 is specially mediated by phosphorylation of IR through activation of the PI3K. Penerbit UTM 2006 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12067/1/JTF_Taher.pdf Bakhtiar, M. Taher and Fadzilah Adibah, Abdul Majid and Mohamad Roji, Sarmidi (2006) A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes. Jurnal Teknologi, 44 (F). pp. 53-68. ISSN 2180-3722 http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/385 10.11113/jt.v44.385
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Fadzilah Adibah, Abdul Majid Mohamad Roji, Sarmidi A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
description	Non-insulin-dependent diabetes mellitus is due to in large part to insulin resistance, a state where the target cells are no longer responding to ordinary levels of circulating insulin. A drug that promotes the initiation of insulin receptor (IR) signaling by enhancing IR phosphorylation should be useful in the treatment of Type 2 diabetes. To investigate a compound that is able to phosphorylate IR, a proanthocyanidin, cinnamtannin B1, has been isolated from the stem bark of Cinnamomum zeylanicum Blume (Lauraceae). The structure of the compound was established by spectroscopic methods. Cinnamtannin B1 (0.11 mM) activates the phosphorylation of insulin receptor β-subunit on 3T3-L1 adipocytes. Like insulin, cinnamtannin B1-stimulated phosphorylation of insulin receptor was inhibited by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) and cytochalasin B, an inhibitor of the glucose transporter (GLUT4); otherwise the phosphorylation was enhanced by vanadate, a tyrosine phosphatase inhibitor. These results suggest that the activity of cinnamtannin B1 is specially mediated by phosphorylation of IR through activation of the PI3K.
format	Article
author	Bakhtiar, M. Taher Fadzilah Adibah, Abdul Majid Mohamad Roji, Sarmidi
author_facet	Bakhtiar, M. Taher Fadzilah Adibah, Abdul Majid Mohamad Roji, Sarmidi
author_sort	Bakhtiar, M. Taher
title	A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
title_short	A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
title_full	A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
title_fullStr	A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
title_full_unstemmed	A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
title_sort	proanthocyanidin from cinnamomum zeylanicum stimulates phosphorylation of insulin receptor in 3t3–l1 adipocytes
publisher	Penerbit UTM
publishDate	2006
url	http://irep.iium.edu.my/12067/ http://irep.iium.edu.my/12067/ http://irep.iium.edu.my/12067/ http://irep.iium.edu.my/12067/1/JTF_Taher.pdf
first_indexed	2023-09-18T20:21:17Z
last_indexed	2023-09-18T20:21:17Z
_version_	1777408123749793792

A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes

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