Bioactivities of a-mangostin from Garcinia malaccensis Hk.f

Guttiferae family is well known to have a wide range of phytochemical sontituents and bioactivities. A phytochemical investigation of Garcinia malaccensis leasd isolaton of a-mangostin, b-mangostin and a triterpenoid. a-Mangostin, a xanthone has a lot of health benefits. Many studies have been repor...

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Main Authors:	Zohri, Farah Syahidah A, Bakhtiar, M. Taher, Darnis, Deny Susanti, Nakazibwe, Sauba, Solachuddin Jauhari, Arief Ichwan
Format:	Conference or Workshop Item
Language:	English English
Published:	2010
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/12148/ http://irep.iium.edu.my/12148/1/Icastcover.pdf http://irep.iium.edu.my/12148/2/Icast2.pdf

id	iium-12148
recordtype	eprints
spelling	iium-121482014-12-09T01:37:26Z http://irep.iium.edu.my/12148/ Bioactivities of a-mangostin from Garcinia malaccensis Hk.f Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan Q Science (General) Guttiferae family is well known to have a wide range of phytochemical sontituents and bioactivities. A phytochemical investigation of Garcinia malaccensis leasd isolaton of a-mangostin, b-mangostin and a triterpenoid. a-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of a-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of a-mangostin. Its structural determination was done based on its spectroscopic analysis. a-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S.aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MBC)value was 0.1mg/mL, indicted that a-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of a-mangostin. In FTC method, a-mangosin was proved to be good lipid peroxidation inhibitor, whereas in DPPH free redical scevenging activity method, it has very weak scavening effects on free radicals. In antiproliferative assay, a-mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20ug/mL. This study can form a foundation for future studies in investigating of biological activities of-amangostin and developing the natural abundant in improving a healthy community. 2010-11-27 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/12148/1/Icastcover.pdf application/pdf en http://irep.iium.edu.my/12148/2/Icast2.pdf Zohri, Farah Syahidah A and Bakhtiar, M. Taher and Darnis, Deny Susanti and Nakazibwe, Sauba and Solachuddin Jauhari, Arief Ichwan (2010) Bioactivities of a-mangostin from Garcinia malaccensis Hk.f. In: International Conference on Advancement in Science and Technology (iCAST2010): The Science of Traditional Practices in Health and Disease, 26-29 Nov 2010, Kuantan, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan Bioactivities of a-mangostin from Garcinia malaccensis Hk.f
description	Guttiferae family is well known to have a wide range of phytochemical sontituents and bioactivities. A phytochemical investigation of Garcinia malaccensis leasd isolaton of a-mangostin, b-mangostin and a triterpenoid. a-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of a-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of a-mangostin. Its structural determination was done based on its spectroscopic analysis. a-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S.aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MBC)value was 0.1mg/mL, indicted that a-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of a-mangostin. In FTC method, a-mangosin was proved to be good lipid peroxidation inhibitor, whereas in DPPH free redical scevenging activity method, it has very weak scavening effects on free radicals. In antiproliferative assay, a-mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20ug/mL. This study can form a foundation for future studies in investigating of biological activities of-amangostin and developing the natural abundant in improving a healthy community.
format	Conference or Workshop Item
author	Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan
author_facet	Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan
author_sort	Zohri, Farah Syahidah A
title	Bioactivities of a-mangostin from Garcinia malaccensis Hk.f
title_short	Bioactivities of a-mangostin from Garcinia malaccensis Hk.f
title_full	Bioactivities of a-mangostin from Garcinia malaccensis Hk.f
title_fullStr	Bioactivities of a-mangostin from Garcinia malaccensis Hk.f
title_full_unstemmed	Bioactivities of a-mangostin from Garcinia malaccensis Hk.f
title_sort	bioactivities of a-mangostin from garcinia malaccensis hk.f
publishDate	2010
url	http://irep.iium.edu.my/12148/ http://irep.iium.edu.my/12148/1/Icastcover.pdf http://irep.iium.edu.my/12148/2/Icast2.pdf
first_indexed	2023-09-18T20:21:23Z
last_indexed	2023-09-18T20:21:23Z
_version_	1777408130612723712

Bioactivities of a-mangostin from Garcinia malaccensis Hk.f

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