Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua

This study was carried out to isolate the active antibacterial compounds from marine sponge Neopetrosiaexigua. Using disc diffusion method, methanol extract of N. exigua showed a significantantibacterial activity. Sequentially, liquid-liquid extraction was performed using different polarity solvents...

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Main Authors:	Qaralleh, Haitham, Syed Osman Idid, Syed Zahir Idid, Saad, Shahbudin, Darnis, Deny Susanti, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English English
Published:	2010
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/12177/ http://irep.iium.edu.my/12177/1/ICYCcover.pdf http://irep.iium.edu.my/12177/2/ICYC.pdf

id	iium-12177
recordtype	eprints
spelling	iium-121772012-01-26T06:52:47Z http://irep.iium.edu.my/12177/ Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua Qaralleh, Haitham Syed Osman Idid, Syed Zahir Idid Saad, Shahbudin Darnis, Deny Susanti Bakhtiar, M. Taher Q Science (General) This study was carried out to isolate the active antibacterial compounds from marine sponge Neopetrosiaexigua. Using disc diffusion method, methanol extract of N. exigua showed a significantantibacterial activity. Sequentially, liquid-liquid extraction was performed using different polarity solvents ( n-hexane, carbon tetrachloride, dichloromethane, n-butanol and water) in order to isolate the active antibacterial compounds. Based on the biological guided fractionation results, diccholoromethane and n-butanol fractions showed the higher antimicrobial activity than other solvents. Purification of n-butanol fraction was done by using Sephadex LH-20, normal phase column chromatography (eluted with water/acetonitrile and acetonitrile/methanol) to yeild four compounds (1-4). All compounds weretested for their antibacterial activity against Bacillus anthracis. The results showed that oth compond 3 and 4 exhibited a significant antibacterial activity. Although the spectroscopy (NMR and FTIR) analysiswas performed, research is still in progress to elucidate the structures of the isolated compounds. 2010-06-23 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/12177/1/ICYCcover.pdf application/pdf en http://irep.iium.edu.my/12177/2/ICYC.pdf Qaralleh, Haitham and Syed Osman Idid, Syed Zahir Idid and Saad, Shahbudin and Darnis, Deny Susanti and Bakhtiar, M. Taher (2010) Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua. In: 3rd International Conference for Young Chemists 2010, 23-25 June 2010, Copthorne Orchid Hotel Penang.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Qaralleh, Haitham Syed Osman Idid, Syed Zahir Idid Saad, Shahbudin Darnis, Deny Susanti Bakhtiar, M. Taher Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua
description	This study was carried out to isolate the active antibacterial compounds from marine sponge Neopetrosiaexigua. Using disc diffusion method, methanol extract of N. exigua showed a significantantibacterial activity. Sequentially, liquid-liquid extraction was performed using different polarity solvents ( n-hexane, carbon tetrachloride, dichloromethane, n-butanol and water) in order to isolate the active antibacterial compounds. Based on the biological guided fractionation results, diccholoromethane and n-butanol fractions showed the higher antimicrobial activity than other solvents. Purification of n-butanol fraction was done by using Sephadex LH-20, normal phase column chromatography (eluted with water/acetonitrile and acetonitrile/methanol) to yeild four compounds (1-4). All compounds weretested for their antibacterial activity against Bacillus anthracis. The results showed that oth compond 3 and 4 exhibited a significant antibacterial activity. Although the spectroscopy (NMR and FTIR) analysiswas performed, research is still in progress to elucidate the structures of the isolated compounds.
format	Conference or Workshop Item
author	Qaralleh, Haitham Syed Osman Idid, Syed Zahir Idid Saad, Shahbudin Darnis, Deny Susanti Bakhtiar, M. Taher
author_facet	Qaralleh, Haitham Syed Osman Idid, Syed Zahir Idid Saad, Shahbudin Darnis, Deny Susanti Bakhtiar, M. Taher
author_sort	Qaralleh, Haitham
title	Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua
title_short	Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua
title_full	Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua
title_fullStr	Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua
title_full_unstemmed	Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua
title_sort	potential antibacterial compounds from malaysian sponges neopetrosiaexigua
publishDate	2010
url	http://irep.iium.edu.my/12177/ http://irep.iium.edu.my/12177/1/ICYCcover.pdf http://irep.iium.edu.my/12177/2/ICYC.pdf
first_indexed	2023-09-18T20:21:25Z
last_indexed	2023-09-18T20:21:25Z
_version_	1777408132251648000

Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua

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