Bioactive constituents from the leaves of Melastoma Malabathricum L

Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L. (Melastomataceae) have been investigated. The n-hexane extract yielded α-amyrin, patriscabatrine and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave quercitrin and kaempferol-...

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Main Authors:	Darnis, Deny Susanti, Mohd. Sirat, Hasnah, Ahmad, Farediah, Mat Ali, Rasadah
Format:	Article
Language:	English
Published:	Universitas Islam Indonesia 2008
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/1227/ http://irep.iium.edu.my/1227/ http://irep.iium.edu.my/1227/1/Bioactive_Constituents_from_the_leaves_of_Melastoma_Malabathricum._L..pdf

id	iium-1227
recordtype	eprints
spelling	iium-12272011-07-29T06:37:46Z http://irep.iium.edu.my/1227/ Bioactive constituents from the leaves of Melastoma Malabathricum L Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah Q Science (General) Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L. (Melastomataceae) have been investigated. The n-hexane extract yielded α-amyrin, patriscabatrine and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op- trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in DPPH method with IC50 of 0.69 µM. α-Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl) glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively. Universitas Islam Indonesia 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/1227/1/Bioactive_Constituents_from_the_leaves_of_Melastoma_Malabathricum._L..pdf Darnis, Deny Susanti and Mohd. Sirat, Hasnah and Ahmad, Farediah and Mat Ali, Rasadah (2008) Bioactive constituents from the leaves of Melastoma Malabathricum L. Jurnal Ilmiah Farmasi, 5 (1). pp. 1-8. http://journal.uii.ac.id/index.php/JIF/article/view/465
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah Bioactive constituents from the leaves of Melastoma Malabathricum L
description	Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L. (Melastomataceae) have been investigated. The n-hexane extract yielded α-amyrin, patriscabatrine and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op- trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in DPPH method with IC50 of 0.69 µM. α-Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl) glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.
format	Article
author	Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah
author_facet	Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah
author_sort	Darnis, Deny Susanti
title	Bioactive constituents from the leaves of Melastoma Malabathricum L
title_short	Bioactive constituents from the leaves of Melastoma Malabathricum L
title_full	Bioactive constituents from the leaves of Melastoma Malabathricum L
title_fullStr	Bioactive constituents from the leaves of Melastoma Malabathricum L
title_full_unstemmed	Bioactive constituents from the leaves of Melastoma Malabathricum L
title_sort	bioactive constituents from the leaves of melastoma malabathricum l
publisher	Universitas Islam Indonesia
publishDate	2008
url	http://irep.iium.edu.my/1227/ http://irep.iium.edu.my/1227/ http://irep.iium.edu.my/1227/1/Bioactive_Constituents_from_the_leaves_of_Melastoma_Malabathricum._L..pdf
first_indexed	2023-09-18T20:08:27Z
last_indexed	2023-09-18T20:08:27Z
_version_	1777407316008632320

Bioactive constituents from the leaves of Melastoma Malabathricum L

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