Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study

Introduction: Tramadol is a weak opioid analgesic, acting mainly on μ-opioid receptor and has been proven to be effective and safe analgesic used for use in post-operative patients. Whereas celecoxib is a highly selective COX-2 inhibitor belonging to the non-steroidal anti-inflammatory drugs (NSAIDs...

Full description

Bibliographic Details
Main Authors:	Mohamed, Rozilah @ Abdul Hadi, Abdullah, Nor Zamzila, Mokhtar, Md Lukman, Osman, Ariff, Mat Nor, Mohd. Basri
Format:	Conference or Workshop Item
Language:	English
Published:	2007
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/12447/ http://irep.iium.edu.my/12447/1/Oral_Celecoxib_and_Tramadol_After_24_Hours_in__Major_Operation.pdf

id	iium-12447
recordtype	eprints
spelling	iium-124472014-02-14T07:41:59Z http://irep.iium.edu.my/12447/ Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study Mohamed, Rozilah @ Abdul Hadi Abdullah, Nor Zamzila Mokhtar, Md Lukman Osman, Ariff Mat Nor, Mohd. Basri R Medicine (General) Introduction: Tramadol is a weak opioid analgesic, acting mainly on μ-opioid receptor and has been proven to be effective and safe analgesic used for use in post-operative patients. Whereas celecoxib is a highly selective COX-2 inhibitor belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) group which reduces inflammation and pain while minimizing gastrointestinal adverse reactions. This selectivity feature makes celecoxib an attractive alternative to opioids for the control of postoperative pain. Aim: The purpose of this study was to evaluate the effectiveness of oral celecoxib in comparison with oral tramadol in term of analgesic properties and the need for additional tablet acetaminophen as rescue pain reliever. Methods: A randomized, single-blinded study was conducted on 160 selected ASA I and II patients who were divided into two groups by a closed-envelope technique to receive either oral tramadol or celecoxib. Following major gynaecology, orthopaedic and general surgery, all patients were given standard patient-controlled analgesia (PCA) regimen with intravenous morphine. Patients received either oral tramadol 100 mg 8 hourly or oral celecoxib 200mg 12 hourly as a pain reliever 24 hours post operation, after they can resume oral intake. Tablets acetaminophens 500mg were ready as a rescue pain reliever. Patients were monitored for pain score according to Modified Pain Score ( 0 : No pain, l : slight pain, 2 : Tolerable pain, 3 : Bad pain, 4 : Worst pain) and side effects. They were again evaluated at 32, 40 and 48 hours post operation. Results: The mean pain score at 24, 32, 40 and 48 hours post operation were 0.84 ± 0.49, 0.60 ± 0.52, 0.29 ± 0.46, 0.11 ± 0.32 in the celecoxib group. In the tramadol group the mean pain score at 24,32,40 and 48 hours post operation were 0.88 ± 0.49, 0.70 ± 0.49, 0.36 ± 0.51 and 0.15 ± 0.36. There were no significant differences in the mean pain score between the two groups at each duration of assessment (p>0.05). None of the patients developed side effects or requested for tablet acetaminophen. Conclusion: This study indicates that oral celecoxib 200 mg 12 hourly is adequate and suitable to be used as an alternative to oral tramadol 100 mg 8 hourly in controlling pain 24 hours following major operation without the need for additional tablet acetarninophen. 2007 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/12447/1/Oral_Celecoxib_and_Tramadol_After_24_Hours_in__Major_Operation.pdf Mohamed, Rozilah @ Abdul Hadi and Abdullah, Nor Zamzila and Mokhtar, Md Lukman and Osman, Ariff and Mat Nor, Mohd. Basri (2007) Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study. In: 27th Annual Scientific Meeting of the Australian Pain Society, 27th April 2007, Adelaide Convention Centre, Adelaide, Australia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohamed, Rozilah @ Abdul Hadi Abdullah, Nor Zamzila Mokhtar, Md Lukman Osman, Ariff Mat Nor, Mohd. Basri Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study
description	Introduction: Tramadol is a weak opioid analgesic, acting mainly on μ-opioid receptor and has been proven to be effective and safe analgesic used for use in post-operative patients. Whereas celecoxib is a highly selective COX-2 inhibitor belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) group which reduces inflammation and pain while minimizing gastrointestinal adverse reactions. This selectivity feature makes celecoxib an attractive alternative to opioids for the control of postoperative pain. Aim: The purpose of this study was to evaluate the effectiveness of oral celecoxib in comparison with oral tramadol in term of analgesic properties and the need for additional tablet acetaminophen as rescue pain reliever. Methods: A randomized, single-blinded study was conducted on 160 selected ASA I and II patients who were divided into two groups by a closed-envelope technique to receive either oral tramadol or celecoxib. Following major gynaecology, orthopaedic and general surgery, all patients were given standard patient-controlled analgesia (PCA) regimen with intravenous morphine. Patients received either oral tramadol 100 mg 8 hourly or oral celecoxib 200mg 12 hourly as a pain reliever 24 hours post operation, after they can resume oral intake. Tablets acetaminophens 500mg were ready as a rescue pain reliever. Patients were monitored for pain score according to Modified Pain Score ( 0 : No pain, l : slight pain, 2 : Tolerable pain, 3 : Bad pain, 4 : Worst pain) and side effects. They were again evaluated at 32, 40 and 48 hours post operation. Results: The mean pain score at 24, 32, 40 and 48 hours post operation were 0.84 ± 0.49, 0.60 ± 0.52, 0.29 ± 0.46, 0.11 ± 0.32 in the celecoxib group. In the tramadol group the mean pain score at 24,32,40 and 48 hours post operation were 0.88 ± 0.49, 0.70 ± 0.49, 0.36 ± 0.51 and 0.15 ± 0.36. There were no significant differences in the mean pain score between the two groups at each duration of assessment (p>0.05). None of the patients developed side effects or requested for tablet acetaminophen. Conclusion: This study indicates that oral celecoxib 200 mg 12 hourly is adequate and suitable to be used as an alternative to oral tramadol 100 mg 8 hourly in controlling pain 24 hours following major operation without the need for additional tablet acetarninophen.
format	Conference or Workshop Item
author	Mohamed, Rozilah @ Abdul Hadi Abdullah, Nor Zamzila Mokhtar, Md Lukman Osman, Ariff Mat Nor, Mohd. Basri
author_facet	Mohamed, Rozilah @ Abdul Hadi Abdullah, Nor Zamzila Mokhtar, Md Lukman Osman, Ariff Mat Nor, Mohd. Basri
author_sort	Mohamed, Rozilah @ Abdul Hadi
title	Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study
title_short	Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study
title_full	Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study
title_fullStr	Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study
title_full_unstemmed	Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study
title_sort	oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study
publishDate	2007
url	http://irep.iium.edu.my/12447/ http://irep.iium.edu.my/12447/1/Oral_Celecoxib_and_Tramadol_After_24_Hours_in__Major_Operation.pdf
first_indexed	2023-09-18T20:21:39Z
last_indexed	2023-09-18T20:21:39Z
_version_	1777408147018743808

Oral celecoxib and tramadol after 24 hours in patients undergoing major operation in kuantan: a randomized comparattve study

Similar Items