In-vitro release study of cassia alata-loaded PLGA microspheres

Senna Alata or Cassia Alata (C. Alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. The purpose of this study was to design poly-(lactide-co-glycolide) (PLGA) microspheres for a controlled delivery of the C. Alata extract, ov...

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Main Authors:	Alfatama, Mulham, Ahmad, Kausar, Mohamed, Farahidah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/12459/ http://irep.iium.edu.my/12459/1/poster_mulham_for_IPBC__final.pdf

id	iium-12459
recordtype	eprints
spelling	iium-124592013-02-13T12:30:32Z http://irep.iium.edu.my/12459/ In-vitro release study of cassia alata-loaded PLGA microspheres Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah RS Pharmacy and materia medica Senna Alata or Cassia Alata (C. Alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. The purpose of this study was to design poly-(lactide-co-glycolide) (PLGA) microspheres for a controlled delivery of the C. Alata extract, over 2–4 weeks. The microspheres were produced by solvent evaporation technique and the desired characteristics, i.e. high encapsulation efficiency and controlled release over 2–4 weeks had been achieved by several optimised parameters including oil/aqueous ratio and the use of buffer system. In vitro drug release of these microspheres was performed in a phosphate-buffered saline solution (pH 7.4) for certain period of time. A prolonged in vitro drug release profile was observed. The release profiles of C. Alata from PLGA microspheres were found to occur with an initial burst release followed by a gradual release phase up to one month. Drug release rates were dependent upon the types of the surfactants employed during the microspheres preparation. It was found that high initial burst release occurred with all types of surfactant used, however higher initial burst was noticed with hydrophilic surfactant (3% Tween 20) at 58.49%. In conclusion, the optimization of formulation parameters allowed us to produce C. Alata loaded PLGA microspheres of suitable characteristics for therapeutic use. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/12459/1/poster_mulham_for_IPBC__final.pdf Alfatama, Mulham and Ahmad, Kausar and Mohamed, Farahidah (2011) In-vitro release study of cassia alata-loaded PLGA microspheres. In: International Postgraduate Conference on Biotechnology 2011, 15-18 Dec 2011, Universiti Malaysia Terengganu.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah In-vitro release study of cassia alata-loaded PLGA microspheres
description	Senna Alata or Cassia Alata (C. Alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. The purpose of this study was to design poly-(lactide-co-glycolide) (PLGA) microspheres for a controlled delivery of the C. Alata extract, over 2–4 weeks. The microspheres were produced by solvent evaporation technique and the desired characteristics, i.e. high encapsulation efficiency and controlled release over 2–4 weeks had been achieved by several optimised parameters including oil/aqueous ratio and the use of buffer system. In vitro drug release of these microspheres was performed in a phosphate-buffered saline solution (pH 7.4) for certain period of time. A prolonged in vitro drug release profile was observed. The release profiles of C. Alata from PLGA microspheres were found to occur with an initial burst release followed by a gradual release phase up to one month. Drug release rates were dependent upon the types of the surfactants employed during the microspheres preparation. It was found that high initial burst release occurred with all types of surfactant used, however higher initial burst was noticed with hydrophilic surfactant (3% Tween 20) at 58.49%. In conclusion, the optimization of formulation parameters allowed us to produce C. Alata loaded PLGA microspheres of suitable characteristics for therapeutic use.
format	Conference or Workshop Item
author	Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah
author_facet	Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah
author_sort	Alfatama, Mulham
title	In-vitro release study of cassia alata-loaded PLGA microspheres
title_short	In-vitro release study of cassia alata-loaded PLGA microspheres
title_full	In-vitro release study of cassia alata-loaded PLGA microspheres
title_fullStr	In-vitro release study of cassia alata-loaded PLGA microspheres
title_full_unstemmed	In-vitro release study of cassia alata-loaded PLGA microspheres
title_sort	in-vitro release study of cassia alata-loaded plga microspheres
publishDate	2011
url	http://irep.iium.edu.my/12459/ http://irep.iium.edu.my/12459/1/poster_mulham_for_IPBC__final.pdf
first_indexed	2023-09-18T20:21:40Z
last_indexed	2023-09-18T20:21:40Z
_version_	1777408147780009984

In-vitro release study of cassia alata-loaded PLGA microspheres

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