Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis

Hepatic steatosis is a common feature of chronic hepatitis C (CHC). It is caused directly by the virus (genotype 3)or host metabolic factors. We analyzed liver biopsy results among all patients selected for the treatment. Methods: We retrospectively looked into CHC patients selected for treatment...

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Main Authors:	Jaafar, Khairul Azhar, Hasmoni, Mohamed Hadzri, Abdul Rashid, Mohd Amran, Md Ralib @ Md Raghib, Ahmad Razali, H, Nora, Satwi, Sapari
Format:	Article
Language:	English
Published:	Springer 2008
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/12784/ http://irep.iium.edu.my/12784/ http://irep.iium.edu.my/12784/1/hepatic_steatosis_among_chronic_hepatitis.pdf

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spelling	iium-127842012-01-05T04:12:37Z http://irep.iium.edu.my/12784/ Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari R Medicine (General) Hepatic steatosis is a common feature of chronic hepatitis C (CHC). It is caused directly by the virus (genotype 3)or host metabolic factors. We analyzed liver biopsy results among all patients selected for the treatment. Methods: We retrospectively looked into CHC patients selected for treatment from 2005 - 2007,Kuantan Hospital, Malaysia. Fifteen patients were identified between the ages of 19 - 58 years. Blood results for HCV RNA viral load, genotyping, lipid profile, liver biopsy (Ishak et al score) and body mass index (BMI) were documented pretreatment. Results: Seven patients were genotype 1, 6 patients were genotype 3 and 1 patient each for genotype 2 and 6 respectively. Majority of patients had mild hepatic steatosis, 60% (n=9/15) pretreatment and highest were among genotype 1, 33.3% (n=5/15), followed by genotype 3, 20% (n=3/15) and genotype 2, 6% (n=1/15). Among them, 8 out of 15 (53.3%) patients had normal trigliseride (TG) level, 5 out of 15 (33.3%) patients had BMI <25 and 6 out of 15 (40%) patients had high viral load (HVL, >400,000 iu/ml). Conclusions: We observed that the majority of patients with CHC had mild hepatic steatosis, 60% (n=9/15) with normal TG, 53.3% (n=8/15) and amongst genotype 1, 33.3% (n=5/15). Higher viral load might have an influence in the development and progression of steatosis in CHC. Springer 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12784/1/hepatic_steatosis_among_chronic_hepatitis.pdf Jaafar, Khairul Azhar and Hasmoni, Mohamed Hadzri and Abdul Rashid, Mohd Amran and Md Ralib @ Md Raghib, Ahmad Razali and H, Nora and Satwi, Sapari (2008) Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis. Hepatology International, 2 (Supp). S513-S514. ISSN 1936-0533 http://www.springerlink.com/content/633706w4251m092w/fulltext.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
description	Hepatic steatosis is a common feature of chronic hepatitis C (CHC). It is caused directly by the virus (genotype 3)or host metabolic factors. We analyzed liver biopsy results among all patients selected for the treatment. Methods: We retrospectively looked into CHC patients selected for treatment from 2005 - 2007,Kuantan Hospital, Malaysia. Fifteen patients were identified between the ages of 19 - 58 years. Blood results for HCV RNA viral load, genotyping, lipid profile, liver biopsy (Ishak et al score) and body mass index (BMI) were documented pretreatment. Results: Seven patients were genotype 1, 6 patients were genotype 3 and 1 patient each for genotype 2 and 6 respectively. Majority of patients had mild hepatic steatosis, 60% (n=9/15) pretreatment and highest were among genotype 1, 33.3% (n=5/15), followed by genotype 3, 20% (n=3/15) and genotype 2, 6% (n=1/15). Among them, 8 out of 15 (53.3%) patients had normal trigliseride (TG) level, 5 out of 15 (33.3%) patients had BMI <25 and 6 out of 15 (40%) patients had high viral load (HVL, >400,000 iu/ml). Conclusions: We observed that the majority of patients with CHC had mild hepatic steatosis, 60% (n=9/15) with normal TG, 53.3% (n=8/15) and amongst genotype 1, 33.3% (n=5/15). Higher viral load might have an influence in the development and progression of steatosis in CHC.
format	Article
author	Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari
author_facet	Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari
author_sort	Jaafar, Khairul Azhar
title	Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
title_short	Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
title_full	Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
title_fullStr	Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
title_full_unstemmed	Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
title_sort	hepatic steatosis among chronic hepatitis c infected patients selected for treatment - a retrospective analysis
publisher	Springer
publishDate	2008
url	http://irep.iium.edu.my/12784/ http://irep.iium.edu.my/12784/ http://irep.iium.edu.my/12784/1/hepatic_steatosis_among_chronic_hepatitis.pdf
first_indexed	2023-09-18T20:21:55Z
last_indexed	2023-09-18T20:21:55Z
_version_	1777408163765551104

Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis

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