Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers

Paraoxonase (PON1) is a high density lipoprotein (HDL) associated enzyme that is known for its function to hydrolyze organophosphate (OPs) into a relatively harmless substance and prevent atherosclerosis by inhibiting oxidative modification of low density lipoprotein (LDL). In some studies low PON1...

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Main Authors:	Ishaka, Aminu, Abdullah, Nor Zamzila, Mohamed, Rozilah @ Abdul Hadi, Samsuddin, Niza, Mohd Rus, Razman
Format:	Conference or Workshop Item
Language:	English English
Published:	2010
Subjects:	RA Public aspects of medicine RA1190 Toxicology RB Pathology
Online Access:	http://irep.iium.edu.my/13728/ http://irep.iium.edu.my/13728/6/Zam_Poster_Grand_Riverview_%5BFinal%5D.ppt http://irep.iium.edu.my/13728/7/Paraoxonase_%28PON1%29_activities_and_lipid_profiles_among_organophosphates_%28OPs%29_pesticide_exposed_workers.pdf

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spelling	iium-137282013-06-12T02:00:20Z http://irep.iium.edu.my/13728/ Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers Ishaka, Aminu Abdullah, Nor Zamzila Mohamed, Rozilah @ Abdul Hadi Samsuddin, Niza Mohd Rus, Razman RA Public aspects of medicine RA1190 Toxicology RB Pathology Paraoxonase (PON1) is a high density lipoprotein (HDL) associated enzyme that is known for its function to hydrolyze organophosphate (OPs) into a relatively harmless substance and prevent atherosclerosis by inhibiting oxidative modification of low density lipoprotein (LDL). In some studies low PON1 activity was reported among individuals who are exposed to OPs, while in different studies low PON1 activity was associated with a high risk of coronary artery disease (CAD). However, the link between OPs exposure and lipid profiles which are known risk factors of CAD has not yet been reported. The aim of our present preliminary study was to compare the activities of PON1 and lipid profiles between the workers who are exposed to OPs and the comparative non-exposed group. This cross sectional comparative study was carried out on a total of 105 subjects comprising of 53 OPs exposed group and 52 comparative non-exposed group. Fasting serum samples were analyzed for PON1 activities towards substrates paraoxon, phenylacetate and diazoxon as well as for total cholesterol, triglycerides, HDL-C and LDL-C. The results showed a significantly lower diazoxonase activity (p<0.05) among the OPs exposed group, but the lipid profiles were not significantly different (p>0.05) between the two groups. Our study suggested that the decreased PON1 activity among OPs exposed individuals cannot be linked to the atherosclerosis and CAD through the lipid profiles. A larger scale study is required to confirm our observation. 2010-06 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/13728/6/Zam_Poster_Grand_Riverview_%5BFinal%5D.ppt application/pdf en http://irep.iium.edu.my/13728/7/Paraoxonase_%28PON1%29_activities_and_lipid_profiles_among_organophosphates_%28OPs%29_pesticide_exposed_workers.pdf Ishaka, Aminu and Abdullah, Nor Zamzila and Mohamed, Rozilah @ Abdul Hadi and Samsuddin, Niza and Mohd Rus, Razman (2010) Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers. In: 11th Symposium for the Malaysian Society of Applied Biology 2010, 13th-15th June 2010, Kota Bharu, Kelantan.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RA Public aspects of medicine RA1190 Toxicology RB Pathology
spellingShingle	RA Public aspects of medicine RA1190 Toxicology RB Pathology Ishaka, Aminu Abdullah, Nor Zamzila Mohamed, Rozilah @ Abdul Hadi Samsuddin, Niza Mohd Rus, Razman Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers
description	Paraoxonase (PON1) is a high density lipoprotein (HDL) associated enzyme that is known for its function to hydrolyze organophosphate (OPs) into a relatively harmless substance and prevent atherosclerosis by inhibiting oxidative modification of low density lipoprotein (LDL). In some studies low PON1 activity was reported among individuals who are exposed to OPs, while in different studies low PON1 activity was associated with a high risk of coronary artery disease (CAD). However, the link between OPs exposure and lipid profiles which are known risk factors of CAD has not yet been reported. The aim of our present preliminary study was to compare the activities of PON1 and lipid profiles between the workers who are exposed to OPs and the comparative non-exposed group. This cross sectional comparative study was carried out on a total of 105 subjects comprising of 53 OPs exposed group and 52 comparative non-exposed group. Fasting serum samples were analyzed for PON1 activities towards substrates paraoxon, phenylacetate and diazoxon as well as for total cholesterol, triglycerides, HDL-C and LDL-C. The results showed a significantly lower diazoxonase activity (p<0.05) among the OPs exposed group, but the lipid profiles were not significantly different (p>0.05) between the two groups. Our study suggested that the decreased PON1 activity among OPs exposed individuals cannot be linked to the atherosclerosis and CAD through the lipid profiles. A larger scale study is required to confirm our observation.
format	Conference or Workshop Item
author	Ishaka, Aminu Abdullah, Nor Zamzila Mohamed, Rozilah @ Abdul Hadi Samsuddin, Niza Mohd Rus, Razman
author_facet	Ishaka, Aminu Abdullah, Nor Zamzila Mohamed, Rozilah @ Abdul Hadi Samsuddin, Niza Mohd Rus, Razman
author_sort	Ishaka, Aminu
title	Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers
title_short	Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers
title_full	Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers
title_fullStr	Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers
title_full_unstemmed	Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers
title_sort	paraoxonase (pon1) activities and lipid profiles among organophosphates (ops) pesticide exposed workers
publishDate	2010
url	http://irep.iium.edu.my/13728/ http://irep.iium.edu.my/13728/6/Zam_Poster_Grand_Riverview_%5BFinal%5D.ppt http://irep.iium.edu.my/13728/7/Paraoxonase_%28PON1%29_activities_and_lipid_profiles_among_organophosphates_%28OPs%29_pesticide_exposed_workers.pdf
first_indexed	2023-09-18T20:22:52Z
last_indexed	2023-09-18T20:22:52Z
_version_	1777408223842664448

Paraoxonase (PON1) activities and lipid profiles among organophosphates (OPs) pesticide exposed workers

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