In silico approach in designing Xylanase for biobleaching industry

The use of hemicellulolytic enzymes has recently attracted considerable interest as a substitute for chlorine chemicals in pulp bleaching. The challenges in incorporating enzyme to the bleaching system are to have a stable and active xylanase at high temperatures and higher alkaline pH conditions....

Full description

Bibliographic Details
Main Authors:	Noorbatcha, Ibrahim Ali, Abdul Hadi, Muaz, Ismail, Ahmad Faris, Hamzah, Mohd. Salleh
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2009
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/13910/ http://irep.iium.edu.my/13910/11/xylanase_paper_ICCPE2009_proceed_p1210-1213.pdf http://irep.iium.edu.my/13910/4/ICCBPE2009_Ibrahim_Accept_let.pdf http://irep.iium.edu.my/13910/5/ICCBPE2009_Proceedings_Cover_Page.pdf http://irep.iium.edu.my/13910/6/ICCBPE2009_Programme_Book.pdf

id	iium-13910
recordtype	eprints
spelling	iium-139102014-01-15T03:30:43Z http://irep.iium.edu.my/13910/ In silico approach in designing Xylanase for biobleaching industry Noorbatcha, Ibrahim Ali Abdul Hadi, Muaz Ismail, Ahmad Faris Hamzah, Mohd. Salleh TP248.13 Biotechnology The use of hemicellulolytic enzymes has recently attracted considerable interest as a substitute for chlorine chemicals in pulp bleaching. The challenges in incorporating enzyme to the bleaching system are to have a stable and active xylanase at high temperatures and higher alkaline pH conditions. In this work we have used computational methods to analyze the structural factors responsible for the activity and themostability of Bacillus circulans xylanase which have been identified as one of the promising xylanase source to treat the pulp before bleaching it through the conventional bleaching sequences. Simulated point mutation shows that arginine substitution potentially increased the number of hydrogen bond; correlate with the xylanase activity and some changes in amino acid sequence specifically to the α-helix and β-sheet appeared to be promising in improving thermostability of xylanase. This in silico method results can be used to develop new efficient xylanase for pulp bleaching industry. 2009-08-19 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/13910/11/xylanase_paper_ICCPE2009_proceed_p1210-1213.pdf application/pdf en http://irep.iium.edu.my/13910/4/ICCBPE2009_Ibrahim_Accept_let.pdf application/pdf en http://irep.iium.edu.my/13910/5/ICCBPE2009_Proceedings_Cover_Page.pdf application/pdf en http://irep.iium.edu.my/13910/6/ICCBPE2009_Programme_Book.pdf Noorbatcha, Ibrahim Ali and Abdul Hadi, Muaz and Ismail, Ahmad Faris and Hamzah, Mohd. Salleh (2009) In silico approach in designing Xylanase for biobleaching industry. In: 3rd International Conference on Chemical & Bioprocess Engineering , 12–14 August 2009, Kota Kinabalu, Sabah.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Noorbatcha, Ibrahim Ali Abdul Hadi, Muaz Ismail, Ahmad Faris Hamzah, Mohd. Salleh In silico approach in designing Xylanase for biobleaching industry
description	The use of hemicellulolytic enzymes has recently attracted considerable interest as a substitute for chlorine chemicals in pulp bleaching. The challenges in incorporating enzyme to the bleaching system are to have a stable and active xylanase at high temperatures and higher alkaline pH conditions. In this work we have used computational methods to analyze the structural factors responsible for the activity and themostability of Bacillus circulans xylanase which have been identified as one of the promising xylanase source to treat the pulp before bleaching it through the conventional bleaching sequences. Simulated point mutation shows that arginine substitution potentially increased the number of hydrogen bond; correlate with the xylanase activity and some changes in amino acid sequence specifically to the α-helix and β-sheet appeared to be promising in improving thermostability of xylanase. This in silico method results can be used to develop new efficient xylanase for pulp bleaching industry.
format	Conference or Workshop Item
author	Noorbatcha, Ibrahim Ali Abdul Hadi, Muaz Ismail, Ahmad Faris Hamzah, Mohd. Salleh
author_facet	Noorbatcha, Ibrahim Ali Abdul Hadi, Muaz Ismail, Ahmad Faris Hamzah, Mohd. Salleh
author_sort	Noorbatcha, Ibrahim Ali
title	In silico approach in designing Xylanase for biobleaching industry
title_short	In silico approach in designing Xylanase for biobleaching industry
title_full	In silico approach in designing Xylanase for biobleaching industry
title_fullStr	In silico approach in designing Xylanase for biobleaching industry
title_full_unstemmed	In silico approach in designing Xylanase for biobleaching industry
title_sort	in silico approach in designing xylanase for biobleaching industry
publishDate	2009
url	http://irep.iium.edu.my/13910/ http://irep.iium.edu.my/13910/11/xylanase_paper_ICCPE2009_proceed_p1210-1213.pdf http://irep.iium.edu.my/13910/4/ICCBPE2009_Ibrahim_Accept_let.pdf http://irep.iium.edu.my/13910/5/ICCBPE2009_Proceedings_Cover_Page.pdf http://irep.iium.edu.my/13910/6/ICCBPE2009_Programme_Book.pdf
first_indexed	2023-09-18T20:23:05Z
last_indexed	2023-09-18T20:23:05Z
_version_	1777408237050527744

In silico approach in designing Xylanase for biobleaching industry

Similar Items