Microencapsulation of gentamicin into PLGA-chitosan matrices

Poly (lactide-co-glycolide) (PLGA), are the most commonly used biodegradable synthetic polymers as it has extensive clinical applications and has shown to be effective in implantation drug delivery. In this project, chitosan mixed with PLGA were used to encapsulate gentamicin (model drug) to evaluat...

Full description

Bibliographic Details
Main Authors:	Abdullah Hazim, Anas, Harun Ismail, Ahmad Fahmi, Awang, Mohamed, Mohamed, Farahidah
Format:	Book Chapter
Language:	English
Published:	IIUM Press 2011
Subjects:	R Medicine (General) RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/13966/ http://irep.iium.edu.my/13966/ http://irep.iium.edu.my/13966/1/CHAPTER_7%5B1%5D.pdf

id	iium-13966
recordtype	eprints
spelling	iium-139662012-08-27T06:41:51Z http://irep.iium.edu.my/13966/ Microencapsulation of gentamicin into PLGA-chitosan matrices Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah R Medicine (General) RS Pharmacy and materia medica Poly (lactide-co-glycolide) (PLGA), are the most commonly used biodegradable synthetic polymers as it has extensive clinical applications and has shown to be effective in implantation drug delivery. In this project, chitosan mixed with PLGA were used to encapsulate gentamicin (model drug) to evaluate feasibility of encapsulating highly water soluble drug. A modified single step solvent-evaporation method was employed to synthesize the microspheres. In this study, different types of surfactants (PVA, Tween 20 and Span 80) were used to test the loading efficiency. surface morphology, and particle size of the microspheres. From the results obtained, fabrication of microspheres using the solvent-evaporation method has successfully produced a locally administered drug delivery system for gentamicin. The application of different types of surfactants has yielded different microspheres characteristics with Tween 20 fabricated microspheres produced the smallest particle size, smooth surface morphology and the highest encapsulation et1iciency IIUM Press 2011 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/13966/1/CHAPTER_7%5B1%5D.pdf Abdullah Hazim, Anas and Harun Ismail, Ahmad Fahmi and Awang, Mohamed and Mohamed, Farahidah (2011) Microencapsulation of gentamicin into PLGA-chitosan matrices. In: Current Issues in Pharmacy. IIUM Press, Kuala Lumpur, pp. 112-128. ISBN 9789674180195 http://rms.research.iium.edu.my/bookstore/default.aspx
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RS Pharmacy and materia medica Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah Microencapsulation of gentamicin into PLGA-chitosan matrices
description	Poly (lactide-co-glycolide) (PLGA), are the most commonly used biodegradable synthetic polymers as it has extensive clinical applications and has shown to be effective in implantation drug delivery. In this project, chitosan mixed with PLGA were used to encapsulate gentamicin (model drug) to evaluate feasibility of encapsulating highly water soluble drug. A modified single step solvent-evaporation method was employed to synthesize the microspheres. In this study, different types of surfactants (PVA, Tween 20 and Span 80) were used to test the loading efficiency. surface morphology, and particle size of the microspheres. From the results obtained, fabrication of microspheres using the solvent-evaporation method has successfully produced a locally administered drug delivery system for gentamicin. The application of different types of surfactants has yielded different microspheres characteristics with Tween 20 fabricated microspheres produced the smallest particle size, smooth surface morphology and the highest encapsulation et1iciency
format	Book Chapter
author	Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah
author_facet	Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah
author_sort	Abdullah Hazim, Anas
title	Microencapsulation of gentamicin into PLGA-chitosan matrices
title_short	Microencapsulation of gentamicin into PLGA-chitosan matrices
title_full	Microencapsulation of gentamicin into PLGA-chitosan matrices
title_fullStr	Microencapsulation of gentamicin into PLGA-chitosan matrices
title_full_unstemmed	Microencapsulation of gentamicin into PLGA-chitosan matrices
title_sort	microencapsulation of gentamicin into plga-chitosan matrices
publisher	IIUM Press
publishDate	2011
url	http://irep.iium.edu.my/13966/ http://irep.iium.edu.my/13966/ http://irep.iium.edu.my/13966/1/CHAPTER_7%5B1%5D.pdf
first_indexed	2023-09-18T20:23:09Z
last_indexed	2023-09-18T20:23:09Z
_version_	1777408241448255488

Microencapsulation of gentamicin into PLGA-chitosan matrices

Similar Items