Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats

Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats

Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties. This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and nitric oxide (NO)–deficient hypertensive rats. OPLE was administered...

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Main Authors: Md. Jaffri, Juliana, Mohamed, Suhaila, Rohimi, Nordanial, Ahmad, Intan Natasya, Mohamed Mustapha, Noordin, Manap, Mohd Yazid
Format: Article
Language:English
Published: Mary Ann Liebert Inc. 2011
Subjects:
RM695 Physical medicine. Physical therapy
Online Access:http://irep.iium.edu.my/15478/
http://irep.iium.edu.my/15478/
http://irep.iium.edu.my/15478/
http://irep.iium.edu.my/15478/1/antihypertensive_paper.pdf
id iium-15478
recordtype eprints
spelling iium-154782013-06-26T01:31:46Z http://irep.iium.edu.my/15478/ Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats Md. Jaffri, Juliana Mohamed, Suhaila Rohimi, Nordanial Ahmad, Intan Natasya Mohamed Mustapha, Noordin Manap, Mohd Yazid RM695 Physical medicine. Physical therapy Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties. This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and nitric oxide (NO)–deficient hypertensive rats. OPLE was administered orally (500 mg=kg of body weight=day) to normotensive Wistar rats and Nx-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. OPLE significantly (P < .05) attenuated blood pressure increases, increased serum NO, reduced lipid peroxidation, and showed antioxidant effects in NO-deficient hypertensive rats. OPLE decreased the coronary arteriole wall-to-lumen ratio to near normal values under NO deficiency. Although OPLE showed good antihypertensive and antioxidant effects under NO deficiency, it was not hypotensive to normal rats and produced no chronic cardiovascular toxicity in any of the rats throughout the 12-week study. This is the first report on the in vivo antihypertensive properties of green tea catechins extracted from an alternative source, namely, oil palm leaf, for use as a medicinal food for hypertension and cardiovascular ailments. Mary Ann Liebert Inc. 2011-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/15478/1/antihypertensive_paper.pdf Md. Jaffri, Juliana and Mohamed, Suhaila and Rohimi, Nordanial and Ahmad, Intan Natasya and Mohamed Mustapha, Noordin and Manap, Mohd Yazid (2011) Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats. Journal of Medicinal Food, 14 (7/8). pp. 775-783. ISSN 1096-620X http://online.liebertpub.com/doi/abs/10.1089/jmf.2010.1170 10.1089/jmf.2010.1170
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RM695 Physical medicine. Physical therapy
spellingShingle RM695 Physical medicine. Physical therapy
Md. Jaffri, Juliana
Mohamed, Suhaila
Rohimi, Nordanial
Ahmad, Intan Natasya
Mohamed Mustapha, Noordin
Manap, Mohd Yazid
Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats
description Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties. This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and nitric oxide (NO)–deficient hypertensive rats. OPLE was administered orally (500 mg=kg of body weight=day) to normotensive Wistar rats and Nx-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. OPLE significantly (P < .05) attenuated blood pressure increases, increased serum NO, reduced lipid peroxidation, and showed antioxidant effects in NO-deficient hypertensive rats. OPLE decreased the coronary arteriole wall-to-lumen ratio to near normal values under NO deficiency. Although OPLE showed good antihypertensive and antioxidant effects under NO deficiency, it was not hypotensive to normal rats and produced no chronic cardiovascular toxicity in any of the rats throughout the 12-week study. This is the first report on the in vivo antihypertensive properties of green tea catechins extracted from an alternative source, namely, oil palm leaf, for use as a medicinal food for hypertension and cardiovascular ailments.
format Article
author Md. Jaffri, Juliana
Mohamed, Suhaila
Rohimi, Nordanial
Ahmad, Intan Natasya
Mohamed Mustapha, Noordin
Manap, Mohd Yazid
author_facet Md. Jaffri, Juliana
Mohamed, Suhaila
Rohimi, Nordanial
Ahmad, Intan Natasya
Mohamed Mustapha, Noordin
Manap, Mohd Yazid
author_sort Md. Jaffri, Juliana
title Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats
title_short Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats
title_full Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats
title_fullStr Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats
title_full_unstemmed Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats
title_sort antihypertensive and cardiovascular effects of catechin-rich oil palm (elaeis guineensis) leaf extract in nitric oxide–deficient rats
publisher Mary Ann Liebert Inc.
publishDate 2011
url http://irep.iium.edu.my/15478/
http://irep.iium.edu.my/15478/
http://irep.iium.edu.my/15478/
http://irep.iium.edu.my/15478/1/antihypertensive_paper.pdf
first_indexed 2023-09-18T20:24:28Z
last_indexed 2023-09-18T20:24:28Z
_version_ 1777408324242767872

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