Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the parti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IIUM Press
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/17382/ http://irep.iium.edu.my/17382/1/priliminary.pdf |
| Summary: | Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in
plants like rice bran. The production of myo-inositol phosphate intermediates has
received much attention due to the remarkable potential health benefits offered by the
compounds. In this study, the cytotoxicity of the partially purified myo-inositol
phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast
cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed
good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in
minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no
inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions
partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7
was only observed at concentration more than 30 mg/ml with more than 40% cells were
inhibited. This indicates that the partially purified rice bran myo-inositol phosphates
degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results
towards the inhibition of cancer cells growth at relatively high concentration. |
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