Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the parti...
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| Language: | English |
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IIUM Press
2011
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| Online Access: | http://irep.iium.edu.my/17382/ http://irep.iium.edu.my/17382/1/priliminary.pdf |
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iium-173822012-01-30T07:08:10Z http://irep.iium.edu.my/17382/ Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. QH301 Biology Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration. IIUM Press 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/17382/1/priliminary.pdf Yusoff, Narazah Mohd and Nuge, Tamrin and Zainan, Nur Hidayah and Hashim, Yumi Zuhanis Has-Yun and Jamal, Parveen and Meor Hussin, Anis Shobirin and Farouk, Abd Alaziem and Salleh, H.M. (2011) Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells. IIUM Engineering Journal, 12 (4). pp. 1-11. ISSN 1511-788X |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
QH301 Biology |
| spellingShingle |
QH301 Biology Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| description |
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in
plants like rice bran. The production of myo-inositol phosphate intermediates has
received much attention due to the remarkable potential health benefits offered by the
compounds. In this study, the cytotoxicity of the partially purified myo-inositol
phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast
cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed
good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in
minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no
inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions
partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7
was only observed at concentration more than 30 mg/ml with more than 40% cells were
inhibited. This indicates that the partially purified rice bran myo-inositol phosphates
degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results
towards the inhibition of cancer cells growth at relatively high concentration. |
| format |
Article |
| author |
Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. |
| author_facet |
Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. |
| author_sort |
Yusoff, Narazah Mohd |
| title |
Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_short |
Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_full |
Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_fullStr |
Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_full_unstemmed |
Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_sort |
preliminary investigation of myo-inositol phosphates produced by asuia279phytase on mcf-7 cancer cells |
| publisher |
IIUM Press |
| publishDate |
2011 |
| url |
http://irep.iium.edu.my/17382/ http://irep.iium.edu.my/17382/1/priliminary.pdf |
| first_indexed |
2023-09-18T20:26:14Z |
| last_indexed |
2023-09-18T20:26:14Z |
| _version_ |
1777408434936741888 |