Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model

Momordica charantia Linn, commonly known as bitter gourd is used as a vegetable in various coun-tries in the world. The extracts of the bitter gourd plants, fruit and seed have been reported to use as a traditional medicine most commonly as anti-diabetic agents. We have studied the Momordica charant...

Full description

Bibliographic Details
Main Authors:	Showkat, Mir, Ullah, M., Ahmed, Nazim Uddin, Islam, Saiful, Sarker, Md. Zaidul Islam, Absar, Nurul
Format:	Article
Language:	English
Published:	Vivek Daniel, Ed.& Pub 2011
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/17403/ http://irep.iium.edu.my/17403/ http://irep.iium.edu.my/17403/2/IJCRR-2011.pdf

id	iium-17403
recordtype	eprints
spelling	iium-174032013-07-02T04:06:39Z http://irep.iium.edu.my/17403/ Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model Showkat, Mir Ullah, M. Ahmed, Nazim Uddin Islam, Saiful Sarker, Md. Zaidul Islam Absar, Nurul QD Chemistry Momordica charantia Linn, commonly known as bitter gourd is used as a vegetable in various coun-tries in the world. The extracts of the bitter gourd plants, fruit and seed have been reported to use as a traditional medicine most commonly as anti-diabetic agents. We have studied the Momordica charantia leaves extract to evaluate the phytochemical constituents as well as its pharmacological action. The ethanolic extract of the leaves showed the presence of alkaloids, flavonoid, glycoside, steroids ,carbohydrates ,protein and amino acid. The present study was carried out using acetic acid-induced writhing and tail-immersion tests in mice, and caragennan induced paw edema in rat. The ethanolic extracts of leaves showed both analgesic and anti inflammatory effect at 500 mg/kg, p.o. These effect was found to be 57.12 % , 43.1% and 58.69% respectively in compare to control animals . The ethanol extract of Momordica charantia leaves was effective in both non-narcotic and narcotic models of nociception, suggesting its possible action via peripheral and cen-tral mechanism .The activity may be attributed to the phytoconstituents viz flavonoids ,steroids present in the extract. Vivek Daniel, Ed.& Pub 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/17403/2/IJCRR-2011.pdf Showkat, Mir and Ullah, M. and Ahmed, Nazim Uddin and Islam, Saiful and Sarker, Md. Zaidul Islam and Absar, Nurul (2011) Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model. International Journal of Contemporary Research and Review, 2 (8). pp. 1-8. ISSN 0976-4852 http://scholar.google.com/scholar?q=International+Journal+of+Contemporary+Research+and+Review&hl=en&as_sdt=0&as_vis=1&oi=scholart
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Showkat, Mir Ullah, M. Ahmed, Nazim Uddin Islam, Saiful Sarker, Md. Zaidul Islam Absar, Nurul Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model
description	Momordica charantia Linn, commonly known as bitter gourd is used as a vegetable in various coun-tries in the world. The extracts of the bitter gourd plants, fruit and seed have been reported to use as a traditional medicine most commonly as anti-diabetic agents. We have studied the Momordica charantia leaves extract to evaluate the phytochemical constituents as well as its pharmacological action. The ethanolic extract of the leaves showed the presence of alkaloids, flavonoid, glycoside, steroids ,carbohydrates ,protein and amino acid. The present study was carried out using acetic acid-induced writhing and tail-immersion tests in mice, and caragennan induced paw edema in rat. The ethanolic extracts of leaves showed both analgesic and anti inflammatory effect at 500 mg/kg, p.o. These effect was found to be 57.12 % , 43.1% and 58.69% respectively in compare to control animals . The ethanol extract of Momordica charantia leaves was effective in both non-narcotic and narcotic models of nociception, suggesting its possible action via peripheral and cen-tral mechanism .The activity may be attributed to the phytoconstituents viz flavonoids ,steroids present in the extract.
format	Article
author	Showkat, Mir Ullah, M. Ahmed, Nazim Uddin Islam, Saiful Sarker, Md. Zaidul Islam Absar, Nurul
author_facet	Showkat, Mir Ullah, M. Ahmed, Nazim Uddin Islam, Saiful Sarker, Md. Zaidul Islam Absar, Nurul
author_sort	Showkat, Mir
title	Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model
title_short	Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model
title_full	Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model
title_fullStr	Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model
title_full_unstemmed	Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model
title_sort	studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia l in animal model
publisher	Vivek Daniel, Ed.& Pub
publishDate	2011
url	http://irep.iium.edu.my/17403/ http://irep.iium.edu.my/17403/ http://irep.iium.edu.my/17403/2/IJCRR-2011.pdf
first_indexed	2023-09-18T20:26:16Z
last_indexed	2023-09-18T20:26:16Z
_version_	1777408437394604032

Studies on analgesic and anti inflammatory effect of the ethanolic leaf extract of momordica charantia L in animal model

Similar Items