Parkinsonism complicating acute organophosphate insecticide poisoning
Organophosphate insecticides have a triphasic effect on the central nervous system, namely acute cholinergic crisis, intermediate syndrome and delayed polyneuropathy. Although acute organophosphate poisoning is relatively common, case reports describing parkinsonism as a neurological comp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academy of Medicine, Singapore
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/18676/ http://irep.iium.edu.my/18676/ http://irep.iium.edu.my/18676/1/V40N3p150.pdf |
| Summary: | Organophosphate insecticides have a triphasic effect
on the central nervous system, namely acute cholinergic
crisis, intermediate syndrome and delayed polyneuropathy.
Although acute organophosphate poisoning is relatively
common, case reports describing parkinsonism as a
neurological complication following an acute intoxication
are limited.
1
We report a case of parkinsonism noted on day
24 of admission following an acute severe organophosphate
poisoning which was successfully treated with benzhexol
and levodopa. Previously, response to levodopa was reported
to be poor in 3 patients studied by Bhatt et al
1whereas amantidine, dopamine agonist and bipiriden have been shown to be helpful.
2To the best of our knowledge, this is
the fi rst case of parkinsonism complicating organophosphate
poisoning which responded to levodopa and benzhexol
therapy. |
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