Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats

This study was designed to explore the anti-diabetic effect of the leaves of Tetracera Scandens Linn. Merr., (T.Scandens L.) (family: Dilleniaceae) (local name: Mempelas kasar) in vivo. Different parts of this plant are used traditionally in the treatment of gout, internal pains, sore throat, hepati...

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Main Authors:	Ahmed, Qamar Uddin, Umar, Abdulrashid
Format:	Conference or Workshop Item
Language:	English
Published:	2010
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/19486/ http://irep.iium.edu.my/19486/ http://irep.iium.edu.my/19486/1/Anti-hyperglycaemic_activity.pdf

id	iium-19486
recordtype	eprints
spelling	iium-194862012-05-31T01:48:03Z http://irep.iium.edu.my/19486/ Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats Ahmed, Qamar Uddin Umar, Abdulrashid R Medicine (General) RB Pathology This study was designed to explore the anti-diabetic effect of the leaves of Tetracera Scandens Linn. Merr., (T.Scandens L.) (family: Dilleniaceae) (local name: Mempelas kasar) in vivo. Different parts of this plant are used traditionally in the treatment of gout, internal pains, sore throat, hepatitis and lowering hypertension. Glucose levels in rats with hyperglycemia induced by alloxan [150mg/kg body weight (b.w.)] were determined after the oral administration of dichloromethane, ethylacetate, and butanol fractions of the leaves of T. scandens L. Dose (500mg/kg b.w.) was administered to both normal and alloxan induced diabetic rats. The highest blood glucose lowering effect was found to be in butanol fraction, followed by ethylacetate and dichloromethane. However, in normal rats no hypoglycemic activity was observed in all the administered fractions when compared with both diabetic and normal controlled groups. The fall of blood glucose was also found to be comparable to that of the effect produced by a standard anti-diabetic drug, glibenclamide (0.6mg/kg b.w.). Phytochemical screening explicitly confirmed the presence of terpenoids and flavonoids in all extracts which collectively might be responsible for its significant anti-hyperglycemic effect. In conclusion, the butanol extract possesses strong antidiabetic activity in comparison to that of ethylacetate while the least activity was exerted by DCM fraction, hence, T. scandens L., could be screened further with respect to finding out its medicinal efficacy particularly towards the treatment of chronic diabetes mellitus. This laid the foundation to study the active compounds of this plant which are responsible for the anti-hyperglycemic activity. 2010 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/19486/1/Anti-hyperglycaemic_activity.pdf Ahmed, Qamar Uddin and Umar, Abdulrashid (2010) Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats. In: 3rd International Conference on Advancement in Science and Technology (iCAST) 2010, 27-29 November 2010, Vistana Hotel, Kuantan, Pahang. http://www.iium.edu.my/icast/2010/index.php?option=com_content&view=article&id=14&Itemid=17
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Ahmed, Qamar Uddin Umar, Abdulrashid Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats
description	This study was designed to explore the anti-diabetic effect of the leaves of Tetracera Scandens Linn. Merr., (T.Scandens L.) (family: Dilleniaceae) (local name: Mempelas kasar) in vivo. Different parts of this plant are used traditionally in the treatment of gout, internal pains, sore throat, hepatitis and lowering hypertension. Glucose levels in rats with hyperglycemia induced by alloxan [150mg/kg body weight (b.w.)] were determined after the oral administration of dichloromethane, ethylacetate, and butanol fractions of the leaves of T. scandens L. Dose (500mg/kg b.w.) was administered to both normal and alloxan induced diabetic rats. The highest blood glucose lowering effect was found to be in butanol fraction, followed by ethylacetate and dichloromethane. However, in normal rats no hypoglycemic activity was observed in all the administered fractions when compared with both diabetic and normal controlled groups. The fall of blood glucose was also found to be comparable to that of the effect produced by a standard anti-diabetic drug, glibenclamide (0.6mg/kg b.w.). Phytochemical screening explicitly confirmed the presence of terpenoids and flavonoids in all extracts which collectively might be responsible for its significant anti-hyperglycemic effect. In conclusion, the butanol extract possesses strong antidiabetic activity in comparison to that of ethylacetate while the least activity was exerted by DCM fraction, hence, T. scandens L., could be screened further with respect to finding out its medicinal efficacy particularly towards the treatment of chronic diabetes mellitus. This laid the foundation to study the active compounds of this plant which are responsible for the anti-hyperglycemic activity.
format	Conference or Workshop Item
author	Ahmed, Qamar Uddin Umar, Abdulrashid
author_facet	Ahmed, Qamar Uddin Umar, Abdulrashid
author_sort	Ahmed, Qamar Uddin
title	Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats
title_short	Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats
title_full	Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats
title_fullStr	Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats
title_full_unstemmed	Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats
title_sort	anti-hyperglycaemic activity of the leaves of tetracera scandens linn (dilleniaceae) in alloxan induced diabetic male albino wistar rats
publishDate	2010
url	http://irep.iium.edu.my/19486/ http://irep.iium.edu.my/19486/ http://irep.iium.edu.my/19486/1/Anti-hyperglycaemic_activity.pdf
first_indexed	2023-09-18T20:29:05Z
last_indexed	2023-09-18T20:29:05Z
_version_	1777408614988775424

Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats

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