Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines

This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations...

Full description

Bibliographic Details
Main Authors:	Sahidin, Nakazibwe, Sauba, Taher, Muhammad, Kumar Saxena, Anil, Arief Ichwan, Solachuddin Jauhari, Ardiyansyah
Format:	Article
Language:	English
Published:	INSI Publications 2011
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/20337/ http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf

id	iium-20337
recordtype	eprints
spelling	iium-203372014-03-11T00:29:38Z http://irep.iium.edu.my/20337/ Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah, RM Therapeutics. Pharmacology This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562 and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested that the curcusone B had strong antiproliferation which was dose dependent and may have potential as an anticancer agent. INSI Publications 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf Sahidin, and Nakazibwe, Sauba and Taher, Muhammad and Kumar Saxena, Anil and Arief Ichwan, Solachuddin Jauhari and Ardiyansyah, (2011) Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines. Australian Journal of Basic and Applied Sciences, 5 (8). pp. 47-51. ISSN 1991-8178
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah, Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
description	This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562 and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested that the curcusone B had strong antiproliferation which was dose dependent and may have potential as an anticancer agent.
format	Article
author	Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah,
author_facet	Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah,
author_sort	Sahidin,
title	Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_short	Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_full	Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_fullStr	Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_full_unstemmed	Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_sort	antiproliferative activity of curcusone b from jatropha curcas on human cancer cell lines
publisher	INSI Publications
publishDate	2011
url	http://irep.iium.edu.my/20337/ http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf
first_indexed	2023-09-18T20:30:30Z
last_indexed	2023-09-18T20:30:30Z
_version_	1777408703300894720

Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines

Similar Items