Survival analysis among lung cancer patients in Pahang

November 2009. Patients with histology confi rmed lung cancer were recruited in the study. Survival time was defi ned from the date of histological diagnosis to time of death. Data on patients’ characteristic, ECOG functional status, staging, treatment were obtained. Kaplan Meier was used to meas...

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Main Authors:	Ng, Teck Han, How, Soon Hin, Kuan, Yeh Chunn, Ab Rahman, Jamalludin, Abdul Rani, Mohammed Fauzi
Format:	Article
Language:	English
Published:	Wiley-Blackwell 2010
Subjects:	R Medicine (General) RA Public aspects of medicine
Online Access:	http://irep.iium.edu.my/21993/ http://irep.iium.edu.my/21993/1/Ng_Teck_Han_j.1440-1843.2010.01865.x.pdf

id	iium-21993
recordtype	eprints
spelling	iium-219932016-03-10T07:09:29Z http://irep.iium.edu.my/21993/ Survival analysis among lung cancer patients in Pahang Ng, Teck Han How, Soon Hin Kuan, Yeh Chunn Ab Rahman, Jamalludin Abdul Rani, Mohammed Fauzi R Medicine (General) RA Public aspects of medicine November 2009. Patients with histology confi rmed lung cancer were recruited in the study. Survival time was defi ned from the date of histological diagnosis to time of death. Data on patients’ characteristic, ECOG functional status, staging, treatment were obtained. Kaplan Meier was used to measure the survival status and compared using log-rank test. Relevant factors were included in Cox Proportional Hazard Regression to identify independent factors affecting the survival of lung cancer patient. Results Of a total of 100 patients enrolled in this study, 81% were males and 82% were smokers. The age ranges from 30 to 83 years with mean (SD) age of 59.6 (11.3) years. There were 68 Malays, 27 Chinese, 3 Indians and 2 Arbogines. ECOG of 0 or 1, 2 and 3 or 4 were found in 47%, 19% and 34% respectively. All patients presented with either stage 3 or 4 (47% in stage 4). Only 45% patients received conventional chemotherapy. Overall, median (SE) survival was 14.8 (3.5) weeks. There were no signifi cant differences in median survival among males vs females, smokers vs non-smokers, Malays vs non- Malays, stage 3 vs stage 4. However, patients with ECOG 0 or 1 had longer median survival than patients with ECOG 2 or more (35.3 week vs 8.9 weeks, p < 0.001). Patients given chemotherapy also had longer median survival than those without chemotherapy (37.4 weeks vs 4.9 weeks, p < 0.001). On multivariate analysis, when all these factor were included in the regression model, only smoker and patients on best supportive care alone were the signifi cant independent negative prognostic factors affecting survival. Conclusion Patients of good performance status of ECOG 0/1 and given chemotherapy were associated with better survival in lung cancer patients. Wiley-Blackwell 2010-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/21993/1/Ng_Teck_Han_j.1440-1843.2010.01865.x.pdf Ng, Teck Han and How, Soon Hin and Kuan, Yeh Chunn and Ab Rahman, Jamalludin and Abdul Rani, Mohammed Fauzi (2010) Survival analysis among lung cancer patients in Pahang. Respirology, 15 (2). p. 72. ISSN 1323-7799
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RA Public aspects of medicine
spellingShingle	R Medicine (General) RA Public aspects of medicine Ng, Teck Han How, Soon Hin Kuan, Yeh Chunn Ab Rahman, Jamalludin Abdul Rani, Mohammed Fauzi Survival analysis among lung cancer patients in Pahang
description	November 2009. Patients with histology confi rmed lung cancer were recruited in the study. Survival time was defi ned from the date of histological diagnosis to time of death. Data on patients’ characteristic, ECOG functional status, staging, treatment were obtained. Kaplan Meier was used to measure the survival status and compared using log-rank test. Relevant factors were included in Cox Proportional Hazard Regression to identify independent factors affecting the survival of lung cancer patient. Results Of a total of 100 patients enrolled in this study, 81% were males and 82% were smokers. The age ranges from 30 to 83 years with mean (SD) age of 59.6 (11.3) years. There were 68 Malays, 27 Chinese, 3 Indians and 2 Arbogines. ECOG of 0 or 1, 2 and 3 or 4 were found in 47%, 19% and 34% respectively. All patients presented with either stage 3 or 4 (47% in stage 4). Only 45% patients received conventional chemotherapy. Overall, median (SE) survival was 14.8 (3.5) weeks. There were no signifi cant differences in median survival among males vs females, smokers vs non-smokers, Malays vs non- Malays, stage 3 vs stage 4. However, patients with ECOG 0 or 1 had longer median survival than patients with ECOG 2 or more (35.3 week vs 8.9 weeks, p < 0.001). Patients given chemotherapy also had longer median survival than those without chemotherapy (37.4 weeks vs 4.9 weeks, p < 0.001). On multivariate analysis, when all these factor were included in the regression model, only smoker and patients on best supportive care alone were the signifi cant independent negative prognostic factors affecting survival. Conclusion Patients of good performance status of ECOG 0/1 and given chemotherapy were associated with better survival in lung cancer patients.
format	Article
author	Ng, Teck Han How, Soon Hin Kuan, Yeh Chunn Ab Rahman, Jamalludin Abdul Rani, Mohammed Fauzi
author_facet	Ng, Teck Han How, Soon Hin Kuan, Yeh Chunn Ab Rahman, Jamalludin Abdul Rani, Mohammed Fauzi
author_sort	Ng, Teck Han
title	Survival analysis among lung cancer patients in Pahang
title_short	Survival analysis among lung cancer patients in Pahang
title_full	Survival analysis among lung cancer patients in Pahang
title_fullStr	Survival analysis among lung cancer patients in Pahang
title_full_unstemmed	Survival analysis among lung cancer patients in Pahang
title_sort	survival analysis among lung cancer patients in pahang
publisher	Wiley-Blackwell
publishDate	2010
url	http://irep.iium.edu.my/21993/ http://irep.iium.edu.my/21993/1/Ng_Teck_Han_j.1440-1843.2010.01865.x.pdf
first_indexed	2023-09-18T20:33:37Z
last_indexed	2023-09-18T20:33:37Z
_version_	1777408899353149440

Survival analysis among lung cancer patients in Pahang

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