Role of high augmentation index in spontaneous intracerebral haemorrhage

Role of high augmentation index in spontaneous intracerebral haemorrhage

Background: Intracerebral haemorrhage (ICH) is the most disabling and least treatable form of stroke. Its risk factors include old age, hypertension, diabetes mellitus, hypercholesterolaemia, smoking and high alcohol intake, which are also associated with arterial stiffness. The aim of the present s...

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Main Authors: Awang, Mohamed Saufi, Lee, Hock Keong, Ghani, Ab Rahman Izaini, Abdullah, Jafri Malin
Format: Article
Language:English
Published: Elsevier 2010
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/23293/
http://irep.iium.edu.my/23293/
http://irep.iium.edu.my/23293/1/n107_1_co_aut.pdf
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spelling iium-232932012-04-17T02:19:52Z http://irep.iium.edu.my/23293/ Role of high augmentation index in spontaneous intracerebral haemorrhage Awang, Mohamed Saufi Lee, Hock Keong Ghani, Ab Rahman Izaini Abdullah, Jafri Malin R Medicine (General) Background: Intracerebral haemorrhage (ICH) is the most disabling and least treatable form of stroke. Its risk factors include old age, hypertension, diabetes mellitus, hypercholesterolaemia, smoking and high alcohol intake, which are also associated with arterial stiffness. The aim of the present study was to determine the prognostic value of high augmentation index (AI), which is a surrogate marker of arterial stiffness, in patients with spontaneous ICH. Methods: A prospective study of 60 patients with spontaneous supratentorial ICH was conducted. Outcome was assessed using the Modified Rankin Scale at 3 months follow-up. Data were collected on age and sex, risk factors for ICH, clinical parameters, laboratory parameters, radiological findings and hospital management. Logistic regression analysis was carried out to identify independent predictors of 3-month outcome and mortality. Results: Admission Glasgow Coma Scale score (OR, 0.7; 95% CI, 0.450-0.971; p = 0.035), total leukocyte count (OR,1.2; 95% CI, 1.028-1.453; p = 0.023) and haematoma volume (OR, 1.1; 95% CI, 1.024-1.204; p = 0.011) were found to be statistically significant in multivariate analysis of 3-month poor outcome. Factors independently associated with mortality were high AI (OR, 8.6; 95%CI, 1.748-40.940; p = 0.007) and midline shift (OR, 7.5; 95%CI, 1.809-31.004; p = 0.005). Conclusion: Admission Glasgow Coma Scale score, total leukocyte count and haematoma volume were significant predictors for 3-month poor outcome; high AI and midline shift were significant predictors for 3-month mortality. © 2010 Asian Surgical Association Elsevier 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23293/1/n107_1_co_aut.pdf Awang, Mohamed Saufi and Lee, Hock Keong and Ghani, Ab Rahman Izaini and Abdullah, Jafri Malin (2010) Role of high augmentation index in spontaneous intracerebral haemorrhage. Asian Journal of Surgery, 33 (1). pp. 42-50. ISSN 1015-9584 http://www.sciencedirect.com/science/article/pii/S1015958410600085
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Awang, Mohamed Saufi
Lee, Hock Keong
Ghani, Ab Rahman Izaini
Abdullah, Jafri Malin
Role of high augmentation index in spontaneous intracerebral haemorrhage
description Background: Intracerebral haemorrhage (ICH) is the most disabling and least treatable form of stroke. Its risk factors include old age, hypertension, diabetes mellitus, hypercholesterolaemia, smoking and high alcohol intake, which are also associated with arterial stiffness. The aim of the present study was to determine the prognostic value of high augmentation index (AI), which is a surrogate marker of arterial stiffness, in patients with spontaneous ICH. Methods: A prospective study of 60 patients with spontaneous supratentorial ICH was conducted. Outcome was assessed using the Modified Rankin Scale at 3 months follow-up. Data were collected on age and sex, risk factors for ICH, clinical parameters, laboratory parameters, radiological findings and hospital management. Logistic regression analysis was carried out to identify independent predictors of 3-month outcome and mortality. Results: Admission Glasgow Coma Scale score (OR, 0.7; 95% CI, 0.450-0.971; p = 0.035), total leukocyte count (OR,1.2; 95% CI, 1.028-1.453; p = 0.023) and haematoma volume (OR, 1.1; 95% CI, 1.024-1.204; p = 0.011) were found to be statistically significant in multivariate analysis of 3-month poor outcome. Factors independently associated with mortality were high AI (OR, 8.6; 95%CI, 1.748-40.940; p = 0.007) and midline shift (OR, 7.5; 95%CI, 1.809-31.004; p = 0.005). Conclusion: Admission Glasgow Coma Scale score, total leukocyte count and haematoma volume were significant predictors for 3-month poor outcome; high AI and midline shift were significant predictors for 3-month mortality. © 2010 Asian Surgical Association
format Article
author Awang, Mohamed Saufi
Lee, Hock Keong
Ghani, Ab Rahman Izaini
Abdullah, Jafri Malin
author_facet Awang, Mohamed Saufi
Lee, Hock Keong
Ghani, Ab Rahman Izaini
Abdullah, Jafri Malin
author_sort Awang, Mohamed Saufi
title Role of high augmentation index in spontaneous intracerebral haemorrhage
title_short Role of high augmentation index in spontaneous intracerebral haemorrhage
title_full Role of high augmentation index in spontaneous intracerebral haemorrhage
title_fullStr Role of high augmentation index in spontaneous intracerebral haemorrhage
title_full_unstemmed Role of high augmentation index in spontaneous intracerebral haemorrhage
title_sort role of high augmentation index in spontaneous intracerebral haemorrhage
publisher Elsevier
publishDate 2010
url http://irep.iium.edu.my/23293/
http://irep.iium.edu.my/23293/
http://irep.iium.edu.my/23293/1/n107_1_co_aut.pdf
first_indexed 2023-09-18T20:35:18Z
last_indexed 2023-09-18T20:35:18Z
_version_ 1777409005541392384

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