Sterilisation effect study on granular hydroxyapatite (HA)

Hydroxyapatite is a calcium phosphate bioceramic that has been shown by many authors to be biocompatible with bioactive properties. It is widely accepted as the best synthetic material available for surgical use as a bone graft substitute. HA granules produced by AMREC-SIRIM from local materials und...

Full description

Bibliographic Details
Main Authors: Saidu, Mohd Fharid, Masri, Mashita, Khalid, Khadijah, Fazan, Fazilah, Khalid, Kamarul Ariffin
Format: Article
Language:English
English
Published: Malaysian Medical Association 2004
Subjects:
Online Access:http://irep.iium.edu.my/23911/
http://irep.iium.edu.my/23911/2/Sterilisation-effect-study-on-granular-hydroxyapatite-%28HA%29._2004_The-Medical-journal-of-Malaysia.htm
http://irep.iium.edu.my/23911/3/Sterilisation-effect-study-on-granular-hydroxyapatite-%28HA%29._2004_The-Medical-journal-of-Malaysia.htm
Description
Summary:Hydroxyapatite is a calcium phosphate bioceramic that has been shown by many authors to be biocompatible with bioactive properties. It is widely accepted as the best synthetic material available for surgical use as a bone graft substitute. HA granules produced by AMREC-SIRIM from local materials underwent 5 types of sterilisation techniques with different ageing periods. Samples were tested for chemical and phase composition and microbial contamination before and after being sterilised. From the microbiological tests done, none of the unsterilised positive control yielded a positive culture. Results from X-Ray diffraction studies found that all the sterilisation techniques did not chemically degrade or structurally change the HA granules significantly.