Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan

Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan

Polymorphisms within the beta2-adrenergic receptor (ADRB2) gene have been repeatedly linked to hypertension. Among the ADRB2 polymorphisms detected, Arg16Gly and Gln27Glu codons are considered the two most important variations. The amino acid substitution at these codons may lead to abnormal regulat...

Full description

Bibliographic Details
Main Authors: Ahmed Elbadri, Atia, Ku Zaifah, Norsidah, Abdullah, Nor Zamzila, Mokhtar, Rafidah Hanim, Draman, Samsul, Md Aris, Mohd Aznan, Abdul Rahman, Rashidah, A.Talib, Norlelawati
Format: Article
Language:English
Published: Malaysian Medical Association 2012
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/24402/
http://irep.iium.edu.my/24402/
http://irep.iium.edu.my/24402/1/Atia_et.al_paper_2012.pdf
id iium-24402
recordtype eprints
spelling iium-244022016-11-12T04:25:04Z http://irep.iium.edu.my/24402/ Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan Ahmed Elbadri, Atia Ku Zaifah, Norsidah Abdullah, Nor Zamzila Mokhtar, Rafidah Hanim Draman, Samsul Md Aris, Mohd Aznan Abdul Rahman, Rashidah A.Talib, Norlelawati R Medicine (General) Polymorphisms within the beta2-adrenergic receptor (ADRB2) gene have been repeatedly linked to hypertension. Among the ADRB2 polymorphisms detected, Arg16Gly and Gln27Glu codons are considered the two most important variations. The amino acid substitution at these codons may lead to abnormal regulation of ADRB2 activity. The aim of the present study was to assess the association between ADRB2 polymorphisms and hypertension. This case-control study consisted of 100 unrelated subjects (50 hypertensive and 50 matched normal controls). Arg16Gly and the Gln27Glu polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism assay. There were no significant evidence of association in allelic and genotypes distribution of Arg16Gly and Glu27Gln with blood pressure and hypertension. These findings suggest that the variation within codon 16 and 27 of ADRB2 gene were unlikely to confer genetic susceptibility for hypertension in our population samples. Malaysian Medical Association 2012-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24402/1/Atia_et.al_paper_2012.pdf Ahmed Elbadri, Atia and Ku Zaifah, Norsidah and Abdullah, Nor Zamzila and Mokhtar, Rafidah Hanim and Draman, Samsul and Md Aris, Mohd Aznan and Abdul Rahman, Rashidah and A.Talib, Norlelawati (2012) Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan. The Medical Journal of Malaysia, 67 (1). pp. 25-30. ISSN 0300-5283 http://www.e-mjm.org/2012/v67n1/Polymorphism.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Ahmed Elbadri, Atia
Ku Zaifah, Norsidah
Abdullah, Nor Zamzila
Mokhtar, Rafidah Hanim
Draman, Samsul
Md Aris, Mohd Aznan
Abdul Rahman, Rashidah
A.Talib, Norlelawati
Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
description Polymorphisms within the beta2-adrenergic receptor (ADRB2) gene have been repeatedly linked to hypertension. Among the ADRB2 polymorphisms detected, Arg16Gly and Gln27Glu codons are considered the two most important variations. The amino acid substitution at these codons may lead to abnormal regulation of ADRB2 activity. The aim of the present study was to assess the association between ADRB2 polymorphisms and hypertension. This case-control study consisted of 100 unrelated subjects (50 hypertensive and 50 matched normal controls). Arg16Gly and the Gln27Glu polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism assay. There were no significant evidence of association in allelic and genotypes distribution of Arg16Gly and Glu27Gln with blood pressure and hypertension. These findings suggest that the variation within codon 16 and 27 of ADRB2 gene were unlikely to confer genetic susceptibility for hypertension in our population samples.
format Article
author Ahmed Elbadri, Atia
Ku Zaifah, Norsidah
Abdullah, Nor Zamzila
Mokhtar, Rafidah Hanim
Draman, Samsul
Md Aris, Mohd Aznan
Abdul Rahman, Rashidah
A.Talib, Norlelawati
author_facet Ahmed Elbadri, Atia
Ku Zaifah, Norsidah
Abdullah, Nor Zamzila
Mokhtar, Rafidah Hanim
Draman, Samsul
Md Aris, Mohd Aznan
Abdul Rahman, Rashidah
A.Talib, Norlelawati
author_sort Ahmed Elbadri, Atia
title Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
title_short Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
title_full Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
title_fullStr Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
title_full_unstemmed Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
title_sort preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending balok health centre, kuantan
publisher Malaysian Medical Association
publishDate 2012
url http://irep.iium.edu.my/24402/
http://irep.iium.edu.my/24402/
http://irep.iium.edu.my/24402/1/Atia_et.al_paper_2012.pdf
first_indexed 2023-09-18T20:36:34Z
last_indexed 2023-09-18T20:36:34Z
_version_ 1777409085193322496

Similar Items