Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique

Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique

In spite of greater use of oils and fats in the food industry, the other applications have not been explored very much. Beside the oleochemical industry, the other areas that attract greater interest nowadays are the utilization of fatty acids and their derivatives in pharmaceutical applications. Wh...

Full description

Bibliographic Details
Main Authors: Omar, Muhammad Nor, Moynihan, Humphrey, Hamilton, Richard J.
Format: Article
Language:English
Published: Korean Chemical Society 2003
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/24441/
http://irep.iium.edu.my/24441/
http://irep.iium.edu.my/24441/1/13S_HODE_Bull_Kor_Chem_Soc.pdf
id iium-24441
recordtype eprints
spelling iium-244412012-08-13T04:54:47Z http://irep.iium.edu.my/24441/ Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique Omar, Muhammad Nor Moynihan, Humphrey Hamilton, Richard J. QD Chemistry In spite of greater use of oils and fats in the food industry, the other applications have not been explored very much. Beside the oleochemical industry, the other areas that attract greater interest nowadays are the utilization of fatty acids and their derivatives in pharmaceutical applications. While most fatty acids are achiral molecules, this lack of chirality becomes a great challenge to the chemists to look into possibilities of transforming them into highly value-added chiral molecules which exhibit a vast variety of biological roles in plants and mammals. The most popular technique to transform achiral fatty acids into their corresponding chiral metabolites is through biotechnology processes.1 With the increasing demands for microbial and enzymatic biotransformation, the search for new biologically active substances has been given great attention. In the case of linoleic acid 1, the enzyme which can transform the acid into a chiral hydroperoxide, i.e. 13S-hydroperoxy-9Z,11E-octadecadienoic acid (13S-HPOD, 2) is called lipoxygenase (LOX). 13SHPOD is a precursor for the formation of 13S-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE, 3) (Scheme 1). Korean Chemical Society 2003 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24441/1/13S_HODE_Bull_Kor_Chem_Soc.pdf Omar, Muhammad Nor and Moynihan, Humphrey and Hamilton, Richard J. (2003) Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique. Bulletin of Korean Chemical Society, 24 (3). pp. 397-399. ISSN 0253-2964 http://newjournal.kcsnet.or.kr/
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
spellingShingle QD Chemistry
Omar, Muhammad Nor
Moynihan, Humphrey
Hamilton, Richard J.
Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique
description In spite of greater use of oils and fats in the food industry, the other applications have not been explored very much. Beside the oleochemical industry, the other areas that attract greater interest nowadays are the utilization of fatty acids and their derivatives in pharmaceutical applications. While most fatty acids are achiral molecules, this lack of chirality becomes a great challenge to the chemists to look into possibilities of transforming them into highly value-added chiral molecules which exhibit a vast variety of biological roles in plants and mammals. The most popular technique to transform achiral fatty acids into their corresponding chiral metabolites is through biotechnology processes.1 With the increasing demands for microbial and enzymatic biotransformation, the search for new biologically active substances has been given great attention. In the case of linoleic acid 1, the enzyme which can transform the acid into a chiral hydroperoxide, i.e. 13S-hydroperoxy-9Z,11E-octadecadienoic acid (13S-HPOD, 2) is called lipoxygenase (LOX). 13SHPOD is a precursor for the formation of 13S-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE, 3) (Scheme 1).
format Article
author Omar, Muhammad Nor
Moynihan, Humphrey
Hamilton, Richard J.
author_facet Omar, Muhammad Nor
Moynihan, Humphrey
Hamilton, Richard J.
author_sort Omar, Muhammad Nor
title Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique
title_short Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique
title_full Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique
title_fullStr Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique
title_full_unstemmed Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique
title_sort scaling-up the production of 13s-hydroxy-9z,11e-octadecadienoic acid (13s-hode) through chemoenzymatic technique
publisher Korean Chemical Society
publishDate 2003
url http://irep.iium.edu.my/24441/
http://irep.iium.edu.my/24441/
http://irep.iium.edu.my/24441/1/13S_HODE_Bull_Kor_Chem_Soc.pdf
first_indexed 2023-09-18T20:36:38Z
last_indexed 2023-09-18T20:36:38Z
_version_ 1777409089986363392

Similar Items