The effect of chronic khat consumption on sperm count and motility in parent mice and their offspring
Khat is considered a psychoactive drug and has many side effects on different parts of the body organs. In this study the effects of khat on sperm count and motility in parent mice and their offspring were investigated. Animals were divided into two groups, Group 1 (khat group) contained twelve m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
EuroJournals Publishing, Inc.
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/24866/ http://irep.iium.edu.my/24866/ http://irep.iium.edu.my/24866/1/Effect_of_Chronic_Khat_on_sperm_in_offspring.pdf |
| Summary: | Khat is considered a psychoactive drug and has many side effects on different parts
of the body organs. In this study the effects of khat on sperm count and motility in parent
mice and their offspring were investigated. Animals were divided into two groups, Group 1
(khat group) contained twelve male and twelve female mice, and they were given a daily
dose of (50mg/kg) body weight khat extract by gastric gavage for four and eight weeks.
Group 2 (control group) also contained twelve male and twelve female mice and received
normal access of food and water. After four weeks of treatment, the males and females
were allowed to mate and khat treatment continued for up to another four weeks. Twenty
four male offspring from group 1 and group 2 were selected randomly and allowed to
become mature. Male parent mice were killed at the 4th and 8th weeks of treatment, and
their male offspring were killed when they reached maturity age (6-8weeks). Physiological
examination of the sperm solution showed that there was a significant increase in sperm
count and motility after 4 and 8 weeks of khat treatment, and in their adult offspring.
Furthermore, histological changes were found in testicular sections of the adult male mice. |
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