Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment

Memory and learning impairment in elderly is becoming an increasing challenge especially in those with vascular risk factors. The fixed oil of Nigella Sativa NSO (black cumin) has revealed considerable antioxidant, anti-inflammatory and immune-modulatory effects which may prevent or arrest the det...

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Main Authors:	Azzubaidi, Marwan Saad, Saxena, Anil Kumar, Talib, Norlelawati A., Ahmed, Qamar Uddin
Format:	Conference or Workshop Item
Language:	English English
Published:	2012
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM300 Drugs and their action RZ400 Mental healing
Online Access:	http://irep.iium.edu.my/24874/ http://irep.iium.edu.my/24874/1/IRIIE-1-_2012.pdf http://irep.iium.edu.my/24874/4/IMG_0065-_effect_of_nigella_sativa_on_chronic_cerebral

id	iium-24874
recordtype	eprints
spelling	iium-248742013-03-15T03:55:14Z http://irep.iium.edu.my/24874/ Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment Azzubaidi, Marwan Saad Saxena, Anil Kumar Talib, Norlelawati A. Ahmed, Qamar Uddin RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM300 Drugs and their action RZ400 Mental healing Memory and learning impairment in elderly is becoming an increasing challenge especially in those with vascular risk factors. The fixed oil of Nigella Sativa NSO (black cumin) has revealed considerable antioxidant, anti-inflammatory and immune-modulatory effects which may prevent or arrest the deteriorating learning and memory brain function. Two vessel occlusion (2VO) in rats has been broadly used as a model for chronic cerebral hypoperfusion. The present experimental study was planned to use Morris water maze (MWM) test to compare the cognitive performance of rats with memory and learning deficits induced by 2VO surgery with that of a healthy Sham control animal group and orally treated with the NSO. 60 Sprague Dawley (SD) rats were equally divided into 2 main groups for long term memory (LTM) protocol and short term memory (STM) with (working memory) protocol of MWM. Each group was subdivided into 3 subgroups (n=10) – Group A, untreated 2VO; Group B, sham control and Group C, orally NSO treated 2VO. For LTM and STM Morris water maze test, both Sham control and NSO treated groups showed significantly lower escape latency time (p<0.01), total distance travelled (p<0.01), longer time spent in the target zone and a higher number of annulus crossings as compared to untreated 2VO group. Working Memory MWM test for both Sham control and NSO treated groups showed significantly lower escape latency time (p<0.01) and total distance travelled (p<0.01) as compared to untreated 2VO. The study suggests that the seeds of Nigella sativa may have potential memory and learning enhancing activity and may open the way for prophylactic use to patients with early signs of memory and/or learning deficits or even those who are at high risk for developing neurodegenerative diseases like Alzheimer’s disease. 2012-02-22 Conference or Workshop Item PeerReviewed application/pdf en cc_by http://irep.iium.edu.my/24874/1/IRIIE-1-_2012.pdf application/pdf en http://irep.iium.edu.my/24874/4/IMG_0065-_effect_of_nigella_sativa_on_chronic_cerebral Azzubaidi, Marwan Saad and Saxena, Anil Kumar and Talib, Norlelawati A. and Ahmed, Qamar Uddin (2012) Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment. In: IIUM Research, Invention and Innovation Exhibition IRIIE 2012, 21-22 February 2012, Kuala Lumpur, Malaysia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM300 Drugs and their action RZ400 Mental healing
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM300 Drugs and their action RZ400 Mental healing Azzubaidi, Marwan Saad Saxena, Anil Kumar Talib, Norlelawati A. Ahmed, Qamar Uddin Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment
description	Memory and learning impairment in elderly is becoming an increasing challenge especially in those with vascular risk factors. The fixed oil of Nigella Sativa NSO (black cumin) has revealed considerable antioxidant, anti-inflammatory and immune-modulatory effects which may prevent or arrest the deteriorating learning and memory brain function. Two vessel occlusion (2VO) in rats has been broadly used as a model for chronic cerebral hypoperfusion. The present experimental study was planned to use Morris water maze (MWM) test to compare the cognitive performance of rats with memory and learning deficits induced by 2VO surgery with that of a healthy Sham control animal group and orally treated with the NSO. 60 Sprague Dawley (SD) rats were equally divided into 2 main groups for long term memory (LTM) protocol and short term memory (STM) with (working memory) protocol of MWM. Each group was subdivided into 3 subgroups (n=10) – Group A, untreated 2VO; Group B, sham control and Group C, orally NSO treated 2VO. For LTM and STM Morris water maze test, both Sham control and NSO treated groups showed significantly lower escape latency time (p<0.01), total distance travelled (p<0.01), longer time spent in the target zone and a higher number of annulus crossings as compared to untreated 2VO group. Working Memory MWM test for both Sham control and NSO treated groups showed significantly lower escape latency time (p<0.01) and total distance travelled (p<0.01) as compared to untreated 2VO. The study suggests that the seeds of Nigella sativa may have potential memory and learning enhancing activity and may open the way for prophylactic use to patients with early signs of memory and/or learning deficits or even those who are at high risk for developing neurodegenerative diseases like Alzheimer’s disease.
format	Conference or Workshop Item
author	Azzubaidi, Marwan Saad Saxena, Anil Kumar Talib, Norlelawati A. Ahmed, Qamar Uddin
author_facet	Azzubaidi, Marwan Saad Saxena, Anil Kumar Talib, Norlelawati A. Ahmed, Qamar Uddin
author_sort	Azzubaidi, Marwan Saad
title	Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment
title_short	Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment
title_full	Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment
title_fullStr	Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment
title_full_unstemmed	Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment
title_sort	effect of nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment
publishDate	2012
url	http://irep.iium.edu.my/24874/ http://irep.iium.edu.my/24874/1/IRIIE-1-_2012.pdf http://irep.iium.edu.my/24874/4/IMG_0065-_effect_of_nigella_sativa_on_chronic_cerebral
first_indexed	2023-09-18T20:37:12Z
last_indexed	2023-09-18T20:37:12Z
_version_	1777409125012996096

Effect of Nigella sativa on chronic cerebral hypoperfusion-induced memory and learning impairment

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