Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice

Light microscopic (LM) and transmission electron microscopic (TEM) observations were performed in the kidneys of oral contraceptive treated mice. Experimental groups were given 0.1 ml of olive oil containing 0.015 fraction of (Neogynon) tablet daily. Control groups were give olive oil alone.Five ex...

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Main Authors:	Al-Ani, Imad Matloub Dally, Noor Al-Deen, Jinan A., Kashmola, Muhanad Ali Hamdon
Format:	Conference or Workshop Item
Language:	English English
Published:	2008
Subjects:	RG Gynecology and obstetrics RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/24876/ http://irep.iium.edu.my/24876/19/Contraception_Power_Point.pps http://irep.iium.edu.my/24876/20/Binder1.pdf

id	iium-24876
recordtype	eprints
spelling	iium-248762015-12-18T02:50:33Z http://irep.iium.edu.my/24876/ Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon RG Gynecology and obstetrics RM300 Drugs and their action Light microscopic (LM) and transmission electron microscopic (TEM) observations were performed in the kidneys of oral contraceptive treated mice. Experimental groups were given 0.1 ml of olive oil containing 0.015 fraction of (Neogynon) tablet daily. Control groups were give olive oil alone.Five experimental and three control animals were scariﬁed after 1,3,6,9,and 12 estrus cycles. Glomerulosclerosis,hyaline arteriopathy associated with focal areas of interstitial ﬁbrosis were observed in the ﬁrst cycle. Mild hypertrophy of juxtaglomerular apparatus “JGA” appeared in the 3rd cycle with increased granularity of the JGCs. Proliferative-sclerosing stages of focal glomerulonephritis were observed and were more advanced in cycle twelve.By transmission electron microscope, there were slight changes in the glomeruli during cycle one. These evident gradually developed in cycle three, thus the glomeruli showed disordered capillary loop occlusion. In cycle six, capillary lumens were occluded by protuberance projection. There were hyperactivity and proliferation of mesangial cells and electron-dense material deposits in glomerular basal lamina; these deposits were accompanied with electron-lucent materials appeared in cycle 9 behind swelled mesangial cells indicating hyperactivity and proliferative cells which showed abundant RER and mitochondria. These lesions were correlated with hyper-granularityof JGCs and hypertrophied JGA. The JGGs appeared in cycle 12 as heterogenized size. These changes indicate that abuse of oral contraceptives is relatively unsafe, especially after long-term of high-do 2008-04 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/24876/19/Contraception_Power_Point.pps application/pdf en http://irep.iium.edu.my/24876/20/Binder1.pdf Al-Ani, Imad Matloub Dally and Noor Al-Deen, Jinan A. and Kashmola, Muhanad Ali Hamdon (2008) Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice. In: 17th EMSM Scientific Conference and 18th Annual General Meeting, 18-20 Dec. 2008, Holiday Inn Glenmarie, Shah Alam, Kuala Lumpur.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics RM300 Drugs and their action
spellingShingle	RG Gynecology and obstetrics RM300 Drugs and their action Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
description	Light microscopic (LM) and transmission electron microscopic (TEM) observations were performed in the kidneys of oral contraceptive treated mice. Experimental groups were given 0.1 ml of olive oil containing 0.015 fraction of (Neogynon) tablet daily. Control groups were give olive oil alone.Five experimental and three control animals were scariﬁed after 1,3,6,9,and 12 estrus cycles. Glomerulosclerosis,hyaline arteriopathy associated with focal areas of interstitial ﬁbrosis were observed in the ﬁrst cycle. Mild hypertrophy of juxtaglomerular apparatus “JGA” appeared in the 3rd cycle with increased granularity of the JGCs. Proliferative-sclerosing stages of focal glomerulonephritis were observed and were more advanced in cycle twelve.By transmission electron microscope, there were slight changes in the glomeruli during cycle one. These evident gradually developed in cycle three, thus the glomeruli showed disordered capillary loop occlusion. In cycle six, capillary lumens were occluded by protuberance projection. There were hyperactivity and proliferation of mesangial cells and electron-dense material deposits in glomerular basal lamina; these deposits were accompanied with electron-lucent materials appeared in cycle 9 behind swelled mesangial cells indicating hyperactivity and proliferative cells which showed abundant RER and mitochondria. These lesions were correlated with hyper-granularityof JGCs and hypertrophied JGA. The JGGs appeared in cycle 12 as heterogenized size. These changes indicate that abuse of oral contraceptives is relatively unsafe, especially after long-term of high-do
format	Conference or Workshop Item
author	Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon
author_facet	Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon
author_sort	Al-Ani, Imad Matloub Dally
title	Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
title_short	Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
title_full	Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
title_fullStr	Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
title_full_unstemmed	Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
title_sort	light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
publishDate	2008
url	http://irep.iium.edu.my/24876/ http://irep.iium.edu.my/24876/19/Contraception_Power_Point.pps http://irep.iium.edu.my/24876/20/Binder1.pdf
first_indexed	2023-09-18T20:37:12Z
last_indexed	2023-09-18T20:37:12Z
_version_	1777409125289820160

Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice

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