$Age-related rarefaction in the fractal dimension of retinal vessel$

Age-related rarefaction in the fractal dimension of retinal vessel

Previous work suggests a general reduction in complexity with aging, referred to as the aging-complexity theory. Fractal dimension (FD) of the vessels in the retina is a global measure of the complexity of the vasculature. However, earlier works did not find any correlation between aging and FD of t...

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Main Authors:	Che Azemin, Mohd. Zulfaezal, Kumar, Dinesh Kant, Wong, Tien Y., Wang, Jie Jin, Mitchell, Paul, Kawasaki, Ryo, Wu, Henry
Format:	Article
Language:	English
Published:	Elsevier Inc. 2012
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/24913/ http://irep.iium.edu.my/24913/ http://irep.iium.edu.my/24913/ http://irep.iium.edu.my/24913/1/Age-related_rarefaction_in_Fractal_Dimension_of_retinal_vasculature.pdf

id	iium-24913
recordtype	eprints
spelling	iium-249132013-01-11T00:57:07Z http://irep.iium.edu.my/24913/ Age-related rarefaction in the fractal dimension of retinal vessel Che Azemin, Mohd. Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry RE Ophthalmology Previous work suggests a general reduction in complexity with aging, referred to as the aging-complexity theory. Fractal dimension (FD) of the vessels in the retina is a global measure of the complexity of the vasculature. However, earlier works did not find any correlation between aging and FD of the retinal vasculature, in contrast to the findings of reduced complexity in other parts of the body. The authors tested the hypothesis that reduced complexity develops with advancing age in the structure of the retinal vasculature. To overcome the limitations of earlier works, a three-dimensional representation of the vasculature, together with Fourier fractal dimension (FFD) techniques, was used. Based on the analysis of 748 retinal images taken of persons aged 49-89 years, we observed a significant decrease in the FFD with aging (p < 0.0001). These data provide evidence supporting rarefaction (i.e. reduction) of the retinal vasculature with aging, consistent with observations from other human organ systems. Elsevier Inc. 2012-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24913/1/Age-related_rarefaction_in_Fractal_Dimension_of_retinal_vasculature.pdf Che Azemin, Mohd. Zulfaezal and Kumar, Dinesh Kant and Wong, Tien Y. and Wang, Jie Jin and Mitchell, Paul and Kawasaki, Ryo and Wu, Henry (2012) Age-related rarefaction in the fractal dimension of retinal vessel. Neurobiology of Aging, 33 (1). 194.e1-194.e4. ISSN 0197-4580 http://www.sciencedirect.com/science/journal/01974580 10.1016/j.neurobiolaging.2010.04.010
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Che Azemin, Mohd. Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry Age-related rarefaction in the fractal dimension of retinal vessel
description	Previous work suggests a general reduction in complexity with aging, referred to as the aging-complexity theory. Fractal dimension (FD) of the vessels in the retina is a global measure of the complexity of the vasculature. However, earlier works did not find any correlation between aging and FD of the retinal vasculature, in contrast to the findings of reduced complexity in other parts of the body. The authors tested the hypothesis that reduced complexity develops with advancing age in the structure of the retinal vasculature. To overcome the limitations of earlier works, a three-dimensional representation of the vasculature, together with Fourier fractal dimension (FFD) techniques, was used. Based on the analysis of 748 retinal images taken of persons aged 49-89 years, we observed a significant decrease in the FFD with aging (p < 0.0001). These data provide evidence supporting rarefaction (i.e. reduction) of the retinal vasculature with aging, consistent with observations from other human organ systems.
format	Article
author	Che Azemin, Mohd. Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry
author_facet	Che Azemin, Mohd. Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry
author_sort	Che Azemin, Mohd. Zulfaezal
title	Age-related rarefaction in the fractal dimension of retinal vessel
title_short	Age-related rarefaction in the fractal dimension of retinal vessel
title_full	Age-related rarefaction in the fractal dimension of retinal vessel
title_fullStr	Age-related rarefaction in the fractal dimension of retinal vessel
title_full_unstemmed	Age-related rarefaction in the fractal dimension of retinal vessel
title_sort	age-related rarefaction in the fractal dimension of retinal vessel
publisher	Elsevier Inc.
publishDate	2012
url	http://irep.iium.edu.my/24913/ http://irep.iium.edu.my/24913/ http://irep.iium.edu.my/24913/ http://irep.iium.edu.my/24913/1/Age-related_rarefaction_in_Fractal_Dimension_of_retinal_vasculature.pdf
first_indexed	2023-09-18T20:37:15Z
last_indexed	2023-09-18T20:37:15Z
_version_	1777409128460713984

Age-related rarefaction in the fractal dimension of retinal vessel

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