Novel formulation of ‘painkiller’ using vegetarian capsule

Solid dosage forms can be generally divided into two broad classes, i.e. tablet and capsule. Although the use of tablet is more complicated in terms of formulation, the simpler capsule has inherent problem of having the origin of animal for its gelatin, major constituent of hard gelatin capsule shel...

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Main Authors:	Mohamed, Farahidah, Awang, Mohamed, Helaluddin , Abul Bashar Mohammed, Hazim, Anas Abdillah
Format:	Conference or Workshop Item
Language:	English
Published:	2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/25023/ http://irep.iium.edu.my/25023/1/IPC_anas_submitted_version.pdf

id	iium-25023
recordtype	eprints
spelling	iium-250232013-02-13T12:33:24Z http://irep.iium.edu.my/25023/ Novel formulation of ‘painkiller’ using vegetarian capsule Mohamed, Farahidah Awang, Mohamed Helaluddin , Abul Bashar Mohammed Hazim, Anas Abdillah RS Pharmacy and materia medica Solid dosage forms can be generally divided into two broad classes, i.e. tablet and capsule. Although the use of tablet is more complicated in terms of formulation, the simpler capsule has inherent problem of having the origin of animal for its gelatin, major constituent of hard gelatin capsule shell. There are a few notorious shortcomings associated with the employment of bovine hard gelatin capsule. Although the source of bovine can be certified halal, but the way the slaughtering is conducted could be an issue. Moreover, the risk of contracting a group of fatal neurodegenerative diseases known as Transmissible Spongiform Encephalopathies (TSEs), especially bovine spongiform encephalopathy (BSE) is highly exposed to the consumers of this bovine-derived gelatin. Therefore, objective of this study is to formulate a painkiller with suitable excipients and encapsulate the powder mix into hard vegetarian capsule. The painkiller of choice is a Non-steroidal Anti-Inflammatory Drug (NSAID) namely Mefenamic Acid, of which the proprietary name is Ponstan®. Several formulation variables were investigated including powder flow properties for each of the ingredients and the powder mix. The effect of the powder mix towards disintegration time of the capsule was evaluated. The disintegration time were compared to that reference drug, Ponstan® capsule. It was found that, each of the ingredients represent different flow properties that contributed to formulation challenge. However, regardless of different ratios of excipients, the disintegration times of the Mefenamic acid vegetarian capsules (MAvege) were within regulatory requirement. In addition, since all excipients employed were of plant origin, the results suggest that this novel formulation of painkiller could be the first promising alternative painkiller suitable for vegetarian. 2012-02 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/25023/1/IPC_anas_submitted_version.pdf Mohamed, Farahidah and Awang, Mohamed and Helaluddin , Abul Bashar Mohammed and Hazim, Anas Abdillah (2012) Novel formulation of ‘painkiller’ using vegetarian capsule. In: IIUM’s 1st International Postgraduate Research Conference, IIPRC 2012, 20-22 Feb 2012, CAC, IIUM Gombak.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohamed, Farahidah Awang, Mohamed Helaluddin , Abul Bashar Mohammed Hazim, Anas Abdillah Novel formulation of ‘painkiller’ using vegetarian capsule
description	Solid dosage forms can be generally divided into two broad classes, i.e. tablet and capsule. Although the use of tablet is more complicated in terms of formulation, the simpler capsule has inherent problem of having the origin of animal for its gelatin, major constituent of hard gelatin capsule shell. There are a few notorious shortcomings associated with the employment of bovine hard gelatin capsule. Although the source of bovine can be certified halal, but the way the slaughtering is conducted could be an issue. Moreover, the risk of contracting a group of fatal neurodegenerative diseases known as Transmissible Spongiform Encephalopathies (TSEs), especially bovine spongiform encephalopathy (BSE) is highly exposed to the consumers of this bovine-derived gelatin. Therefore, objective of this study is to formulate a painkiller with suitable excipients and encapsulate the powder mix into hard vegetarian capsule. The painkiller of choice is a Non-steroidal Anti-Inflammatory Drug (NSAID) namely Mefenamic Acid, of which the proprietary name is Ponstan®. Several formulation variables were investigated including powder flow properties for each of the ingredients and the powder mix. The effect of the powder mix towards disintegration time of the capsule was evaluated. The disintegration time were compared to that reference drug, Ponstan® capsule. It was found that, each of the ingredients represent different flow properties that contributed to formulation challenge. However, regardless of different ratios of excipients, the disintegration times of the Mefenamic acid vegetarian capsules (MAvege) were within regulatory requirement. In addition, since all excipients employed were of plant origin, the results suggest that this novel formulation of painkiller could be the first promising alternative painkiller suitable for vegetarian.
format	Conference or Workshop Item
author	Mohamed, Farahidah Awang, Mohamed Helaluddin , Abul Bashar Mohammed Hazim, Anas Abdillah
author_facet	Mohamed, Farahidah Awang, Mohamed Helaluddin , Abul Bashar Mohammed Hazim, Anas Abdillah
author_sort	Mohamed, Farahidah
title	Novel formulation of ‘painkiller’ using vegetarian capsule
title_short	Novel formulation of ‘painkiller’ using vegetarian capsule
title_full	Novel formulation of ‘painkiller’ using vegetarian capsule
title_fullStr	Novel formulation of ‘painkiller’ using vegetarian capsule
title_full_unstemmed	Novel formulation of ‘painkiller’ using vegetarian capsule
title_sort	novel formulation of ‘painkiller’ using vegetarian capsule
publishDate	2012
url	http://irep.iium.edu.my/25023/ http://irep.iium.edu.my/25023/1/IPC_anas_submitted_version.pdf
first_indexed	2023-09-18T20:37:25Z
last_indexed	2023-09-18T20:37:25Z
_version_	1777409138907676672

Novel formulation of ‘painkiller’ using vegetarian capsule

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