Batch process modelling and economic evaluation of glucuronidase enzyme production

β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a commercial batch process simulator. The study focuses on designing an economical...

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Main Authors:	Kamuri, M Firdaus, Foo, Dominic Chwan Yee, Mel, Maizirwan
Format:	Article
Language:	English
Published:	OMICS Group 2012
Subjects:	TP155 Chemical engineering TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/25805/ http://irep.iium.edu.my/25805/ http://irep.iium.edu.my/25805/1/J_Bioprocess_and_Biotechniques.pdf

id	iium-25805
recordtype	eprints
spelling	iium-258052012-11-06T02:21:02Z http://irep.iium.edu.my/25805/ Batch process modelling and economic evaluation of glucuronidase enzyme production Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan TP155 Chemical engineering TP248.13 Biotechnology β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a commercial batch process simulator. The study focuses on designing an economically viable β- glucuronidases enzyme production process. In the base case process, an annual production of 956 batches (corresponding to 8,523 kg) of β- glucuronidases enzyme was made. Seven alternatives production schemes were further developed for increased production using batch debottlenecking strategy. The best alternative scheme was reported to achieve a product yield of 100% increment, with an annual production of 1912 batches of β- glucuronidases enzyme. Economic analysis determined that the proposed alternative scheme has an annual revenue of USD 44M, with a 15.24% gross margin and a 29.44% of return on investment. The payback period of this scheme was estimated to be less than four years. OMICS Group 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/25805/1/J_Bioprocess_and_Biotechniques.pdf Kamuri, M Firdaus and Foo, Dominic Chwan Yee and Mel, Maizirwan (2012) Batch process modelling and economic evaluation of glucuronidase enzyme production. Bioprocessing and Biotechniques (S4). pp. 1-7. ISSN 2155-9821 http://dx.doi.org/10.4172/2155-9821.S4-001
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP155 Chemical engineering TP248.13 Biotechnology
spellingShingle	TP155 Chemical engineering TP248.13 Biotechnology Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan Batch process modelling and economic evaluation of glucuronidase enzyme production
description	β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a commercial batch process simulator. The study focuses on designing an economically viable β- glucuronidases enzyme production process. In the base case process, an annual production of 956 batches (corresponding to 8,523 kg) of β- glucuronidases enzyme was made. Seven alternatives production schemes were further developed for increased production using batch debottlenecking strategy. The best alternative scheme was reported to achieve a product yield of 100% increment, with an annual production of 1912 batches of β- glucuronidases enzyme. Economic analysis determined that the proposed alternative scheme has an annual revenue of USD 44M, with a 15.24% gross margin and a 29.44% of return on investment. The payback period of this scheme was estimated to be less than four years.
format	Article
author	Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan
author_facet	Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan
author_sort	Kamuri, M Firdaus
title	Batch process modelling and economic evaluation of glucuronidase enzyme production
title_short	Batch process modelling and economic evaluation of glucuronidase enzyme production
title_full	Batch process modelling and economic evaluation of glucuronidase enzyme production
title_fullStr	Batch process modelling and economic evaluation of glucuronidase enzyme production
title_full_unstemmed	Batch process modelling and economic evaluation of glucuronidase enzyme production
title_sort	batch process modelling and economic evaluation of glucuronidase enzyme production
publisher	OMICS Group
publishDate	2012
url	http://irep.iium.edu.my/25805/ http://irep.iium.edu.my/25805/ http://irep.iium.edu.my/25805/1/J_Bioprocess_and_Biotechniques.pdf
first_indexed	2023-09-18T20:38:27Z
last_indexed	2023-09-18T20:38:27Z
_version_	1777409203477938176

Batch process modelling and economic evaluation of glucuronidase enzyme production

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