Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)

Sapium baccatum is usually used as a timber. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects were assessed...

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Main Authors:	Bakhtiar, M. Taher, Mat Alewi, Nur Aizura, Darnis, Deny Susanti, Zamli, Zaitunnatakhin, Ramli, Norazsida, Saad, Nurulwahida
Format:	Article
Language:	English
Published:	Penerbit UKM 2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/26052/ http://irep.iium.edu.my/26052/ http://irep.iium.edu.my/26052/1/Sains_Malaysiana11_Muhammad_Taher.pdf

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recordtype	eprints
spelling	iium-260522014-12-08T10:09:16Z http://irep.iium.edu.my/26052/ Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus) Bakhtiar, M. Taher Mat Alewi, Nur Aizura Darnis, Deny Susanti Zamli, Zaitunnatakhin Ramli, Norazsida Saad, Nurulwahida RS Pharmacy and materia medica Sapium baccatum is usually used as a timber. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects were assessed through observation of physiological changes of the rats as well as through gross and histological examinations of its livers. The doses for the treated groups were given intraperitoneally for T2, T3 and T4 group which were given 100, 250 and 500 mg/kg, respectively. Meanwhile, control group (T1) was administered with 80 % PEG 200 only. The observation period was 14 days. If the rat died, it was dissected and the liver was removed and examined. Some physiological effects observed include ataxia and hind-legs paralysis. The gross observations of the livers, growth of abnormal spots and connective tissues attachment to lobes of the livers were observed. The experiment was followed by histopathological observation, which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell linings for T2 group. Results also indicated an increase in the distortion of hepatocytes, presence of massive cytoplasm and necrosis of hepatocytes for T3 and T4 groups. Therefore, results suggest that non polar extract of the stem bark of S. baccatum may promote toxic effects to the animals. Penerbit UKM 2012-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/26052/1/Sains_Malaysiana11_Muhammad_Taher.pdf Bakhtiar, M. Taher and Mat Alewi, Nur Aizura and Darnis, Deny Susanti and Zamli, Zaitunnatakhin and Ramli, Norazsida and Saad, Nurulwahida (2012) Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus). Sains Malaysiana, 41 (11). pp. 1423-1429. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol41num11_2012/contentsVol41num11_2012.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Mat Alewi, Nur Aizura Darnis, Deny Susanti Zamli, Zaitunnatakhin Ramli, Norazsida Saad, Nurulwahida Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)
description	Sapium baccatum is usually used as a timber. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects were assessed through observation of physiological changes of the rats as well as through gross and histological examinations of its livers. The doses for the treated groups were given intraperitoneally for T2, T3 and T4 group which were given 100, 250 and 500 mg/kg, respectively. Meanwhile, control group (T1) was administered with 80 % PEG 200 only. The observation period was 14 days. If the rat died, it was dissected and the liver was removed and examined. Some physiological effects observed include ataxia and hind-legs paralysis. The gross observations of the livers, growth of abnormal spots and connective tissues attachment to lobes of the livers were observed. The experiment was followed by histopathological observation, which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell linings for T2 group. Results also indicated an increase in the distortion of hepatocytes, presence of massive cytoplasm and necrosis of hepatocytes for T3 and T4 groups. Therefore, results suggest that non polar extract of the stem bark of S. baccatum may promote toxic effects to the animals.
format	Article
author	Bakhtiar, M. Taher Mat Alewi, Nur Aizura Darnis, Deny Susanti Zamli, Zaitunnatakhin Ramli, Norazsida Saad, Nurulwahida
author_facet	Bakhtiar, M. Taher Mat Alewi, Nur Aizura Darnis, Deny Susanti Zamli, Zaitunnatakhin Ramli, Norazsida Saad, Nurulwahida
author_sort	Bakhtiar, M. Taher
title	Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)
title_short	Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)
title_full	Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)
title_fullStr	Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)
title_full_unstemmed	Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)
title_sort	toxic effects of sapium baccatum (ludai) extract in rats (kesan toksik ekstrak sapium baccatum (ludai) ke atas tikus)
publisher	Penerbit UKM
publishDate	2012
url	http://irep.iium.edu.my/26052/ http://irep.iium.edu.my/26052/ http://irep.iium.edu.my/26052/1/Sains_Malaysiana11_Muhammad_Taher.pdf
first_indexed	2023-09-18T20:38:51Z
last_indexed	2023-09-18T20:38:51Z
_version_	1777409228911149056

Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)

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