Microencapsulation of Cassia Alata: fabrication and characterization

Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata, followed by microencapsulation by solvent-evaporation using biodegradable PLGA. The microsphere is en...

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Main Authors:	Alfatama, Mulham, Ahmad, Kausar, Mohamed, Farahidah
Format:	Article
Language:	English
Published:	Academic Sciences 2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/26947/ http://irep.iium.edu.my/26947/ http://irep.iium.edu.my/26947/1/MIcroenapsulation_of_cassia_alata_fabrication_n_characterization.pdf

id	iium-26947
recordtype	eprints
spelling	iium-269472014-06-16T02:44:58Z http://irep.iium.edu.my/26947/ Microencapsulation of Cassia Alata: fabrication and characterization Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah RS Pharmacy and materia medica Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata, followed by microencapsulation by solvent-evaporation using biodegradable PLGA. The microsphere is envisaged to release the extract in a controlled manner allowing more convenient mode of administration when treating related skin infection. Several variables had been investigated including different types of surfactants and buffer systems and different homogenization times for primary emulsion. It was found that, most of the surfactants employed resulted in low encapsulation efficiency (<10%). However with 3% poly vinyl alcohol (PVA), slightly higher encapsulation efficiency of 11% was achieved, with size distribution of 7-13 μm. The encapsulation efficiencies were significantly improved (45-64.4%) when the hardening tank was buffered to pH 7, with minimal effect on particle size. Additionally, in-vitro controlled release formulation of C. alata microsphere was demonstrated for duration of almost a month. Academic Sciences 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/26947/1/MIcroenapsulation_of_cassia_alata_fabrication_n_characterization.pdf Alfatama, Mulham and Ahmad, Kausar and Mohamed, Farahidah (2012) Microencapsulation of Cassia Alata: fabrication and characterization. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4). pp. 219-224. ISSN 0975-1491 http://www.ijppsjournal.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah Microencapsulation of Cassia Alata: fabrication and characterization
description	Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata, followed by microencapsulation by solvent-evaporation using biodegradable PLGA. The microsphere is envisaged to release the extract in a controlled manner allowing more convenient mode of administration when treating related skin infection. Several variables had been investigated including different types of surfactants and buffer systems and different homogenization times for primary emulsion. It was found that, most of the surfactants employed resulted in low encapsulation efficiency (<10%). However with 3% poly vinyl alcohol (PVA), slightly higher encapsulation efficiency of 11% was achieved, with size distribution of 7-13 μm. The encapsulation efficiencies were significantly improved (45-64.4%) when the hardening tank was buffered to pH 7, with minimal effect on particle size. Additionally, in-vitro controlled release formulation of C. alata microsphere was demonstrated for duration of almost a month.
format	Article
author	Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah
author_facet	Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah
author_sort	Alfatama, Mulham
title	Microencapsulation of Cassia Alata: fabrication and characterization
title_short	Microencapsulation of Cassia Alata: fabrication and characterization
title_full	Microencapsulation of Cassia Alata: fabrication and characterization
title_fullStr	Microencapsulation of Cassia Alata: fabrication and characterization
title_full_unstemmed	Microencapsulation of Cassia Alata: fabrication and characterization
title_sort	microencapsulation of cassia alata: fabrication and characterization
publisher	Academic Sciences
publishDate	2012
url	http://irep.iium.edu.my/26947/ http://irep.iium.edu.my/26947/ http://irep.iium.edu.my/26947/1/MIcroenapsulation_of_cassia_alata_fabrication_n_characterization.pdf
first_indexed	2023-09-18T20:40:04Z
last_indexed	2023-09-18T20:40:04Z
_version_	1777409305808470016

Microencapsulation of Cassia Alata: fabrication and characterization

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