Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats
In the present study, in addition to 30 days antihyperglycaemic effect of curry leaves of Murraya koenigii "MK" aqueous leaf extract, we also examined its possible effects on the Islets of Langerhans and nephro-protective potential in Streptozotocin (STZ) induced diabetic rats. Male Spra...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/27090/ http://irep.iium.edu.my/27090/ http://irep.iium.edu.my/27090/1/effects_of_murraya_koenigil.pdf |
| Summary: | In the present study, in addition to 30 days antihyperglycaemic effect of curry leaves of Murraya
koenigii "MK" aqueous leaf extract, we also examined its possible effects on the Islets of Langerhans
and nephro-protective potential in Streptozotocin (STZ) induced diabetic rats. Male Sprague Dawley rats
received a single dose of STZ (70 mg/kg) intraperitoneally to induce experimental diabetes. Rats were
randomized into five groups (n=6) of normal control, diabetic control (non-treated), and diabetic treated
with MK aqueous leaf extract. The fresh leaves of MK was extracted with distilled water and freeze-dried
to powder. Blood glucose levels and body weight were monitored gravimetrically. The animals were killed
on the 30th day, kidney and the pancreatic tissues were harvested, and the tissue specimens were fixed
in 10% formal saline for 48hrs, and processed for histological studies. Diabetic rats treated with aqueous
extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The
MK extract also showed improvements in tissue injury induced by STZ. Thus, these findings highlighted
the beneficial effects of curry leaf aqueous extract against STZ induced cellular damage and may exert
anti-hyperglycemic action and regeneration of kidney and islet cell induced in diabetic rats. |
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