Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats
In the present study, in addition to 30 days antihyperglycaemic effect of curry leaves of Murraya koenigii "MK" aqueous leaf extract, we also examined its possible effects on the Islets of Langerhans and nephro-protective potential in Streptozotocin (STZ) induced diabetic rats. Male Spra...
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2012
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| Online Access: | http://irep.iium.edu.my/27090/ http://irep.iium.edu.my/27090/ http://irep.iium.edu.my/27090/1/effects_of_murraya_koenigil.pdf |
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iium-270902014-01-15T07:45:57Z http://irep.iium.edu.my/27090/ Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats Al-Ani, Imad Matloub Dally Imam Santosa , Rahajoe Yankuzo, Muhammad H. Saxena, Anil Kumar R Medicine (General) In the present study, in addition to 30 days antihyperglycaemic effect of curry leaves of Murraya koenigii "MK" aqueous leaf extract, we also examined its possible effects on the Islets of Langerhans and nephro-protective potential in Streptozotocin (STZ) induced diabetic rats. Male Sprague Dawley rats received a single dose of STZ (70 mg/kg) intraperitoneally to induce experimental diabetes. Rats were randomized into five groups (n=6) of normal control, diabetic control (non-treated), and diabetic treated with MK aqueous leaf extract. The fresh leaves of MK was extracted with distilled water and freeze-dried to powder. Blood glucose levels and body weight were monitored gravimetrically. The animals were killed on the 30th day, kidney and the pancreatic tissues were harvested, and the tissue specimens were fixed in 10% formal saline for 48hrs, and processed for histological studies. Diabetic rats treated with aqueous extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The MK extract also showed improvements in tissue injury induced by STZ. Thus, these findings highlighted the beneficial effects of curry leaf aqueous extract against STZ induced cellular damage and may exert anti-hyperglycemic action and regeneration of kidney and islet cell induced in diabetic rats. 2012 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/27090/1/effects_of_murraya_koenigil.pdf Al-Ani, Imad Matloub Dally and Imam Santosa , Rahajoe and Yankuzo, Muhammad H. and Saxena, Anil Kumar (2012) Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats. In: 21st Scientific Conference of the Microscopy Society Malaysia, 22nd-24th November 2012, Renaissance Hotel, Kota Bharu, Kelantan, Malaysia. http://www.emsm2012.kk.usm.my |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
R Medicine (General) |
| spellingShingle |
R Medicine (General) Al-Ani, Imad Matloub Dally Imam Santosa , Rahajoe Yankuzo, Muhammad H. Saxena, Anil Kumar Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats |
| description |
In the present study, in addition to 30 days antihyperglycaemic effect of curry leaves of Murraya
koenigii "MK" aqueous leaf extract, we also examined its possible effects on the Islets of Langerhans
and nephro-protective potential in Streptozotocin (STZ) induced diabetic rats. Male Sprague Dawley rats
received a single dose of STZ (70 mg/kg) intraperitoneally to induce experimental diabetes. Rats were
randomized into five groups (n=6) of normal control, diabetic control (non-treated), and diabetic treated
with MK aqueous leaf extract. The fresh leaves of MK was extracted with distilled water and freeze-dried
to powder. Blood glucose levels and body weight were monitored gravimetrically. The animals were killed
on the 30th day, kidney and the pancreatic tissues were harvested, and the tissue specimens were fixed
in 10% formal saline for 48hrs, and processed for histological studies. Diabetic rats treated with aqueous
extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The
MK extract also showed improvements in tissue injury induced by STZ. Thus, these findings highlighted
the beneficial effects of curry leaf aqueous extract against STZ induced cellular damage and may exert
anti-hyperglycemic action and regeneration of kidney and islet cell induced in diabetic rats. |
| format |
Conference or Workshop Item |
| author |
Al-Ani, Imad Matloub Dally Imam Santosa , Rahajoe Yankuzo, Muhammad H. Saxena, Anil Kumar |
| author_facet |
Al-Ani, Imad Matloub Dally Imam Santosa , Rahajoe Yankuzo, Muhammad H. Saxena, Anil Kumar |
| author_sort |
Al-Ani, Imad Matloub Dally |
| title |
Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats |
| title_short |
Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats |
| title_full |
Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats |
| title_fullStr |
Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats |
| title_full_unstemmed |
Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats |
| title_sort |
effects of murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats |
| publishDate |
2012 |
| url |
http://irep.iium.edu.my/27090/ http://irep.iium.edu.my/27090/ http://irep.iium.edu.my/27090/1/effects_of_murraya_koenigil.pdf |
| first_indexed |
2023-09-18T20:40:16Z |
| last_indexed |
2023-09-18T20:40:16Z |
| _version_ |
1777409318461636608 |