The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients

The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients

The reduction of capillary luminal area within dermal microcirculation in diabetic foot patients contributes towards the development of foot ulceration and subsequent failure to heal existing ulcers. We studied 42 subjects, involving 10 controls, 16 patients with neuropathic ulcer and 16 patients wi...

Full description

Bibliographic Details
Main Authors: Radzuan, Hazulin, Myint, Yi Yi, Tun, Ye, Zulkifly, Ahmad Hafiz
Format: Conference or Workshop Item
Language:English
Published: 2012
Subjects:
QM Human anatomy
Online Access:http://irep.iium.edu.my/27249/
http://irep.iium.edu.my/27249/1/MJM_poster_Hazulin.pdf
id iium-27249
recordtype eprints
spelling iium-272492017-06-22T02:07:23Z http://irep.iium.edu.my/27249/ The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz QM Human anatomy The reduction of capillary luminal area within dermal microcirculation in diabetic foot patients contributes towards the development of foot ulceration and subsequent failure to heal existing ulcers. We studied 42 subjects, involving 10 controls, 16 patients with neuropathic ulcer and 16 patients with neuroischaemic ulcer. The specimens were taken by using skin punch biopsy and were routinely processed for light microscopy. The mean capillary luminal area (LA) and outer area (OA) were performed by calculating and measuring 3 selected capillaries in each slide of every patient and their percentages of ratio were recorded. We noted that there was significant decrement in percentages of LA:OA among the diseased group as compared to the controls, F(2, 39)=17.54, p<0.05. The Tukey post-hoc comparisons showed that the percentages of LA:OA of neuroischemic group (M=31.89, 95% CI [24.79, 39.00]) was significantly reduced as compared to neuropathic group (M=41.76, 95% CI [37.69, 45.82]) since p<0.05. In conclusion, the reduction of dermal capillary luminal area among diabetic foot patients could be due to the alteration in the microvascular hemeorheology, causing basement membrane thickening as the results of the metabolic disease. 2012-11-22 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/27249/1/MJM_poster_Hazulin.pdf Radzuan, Hazulin and Myint, Yi Yi and Tun, Ye and Zulkifly, Ahmad Hafiz (2012) The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients. In: 21st Scientific Conference Of The Microscopy Society Malaysia, 22-24 Nov 2012, Kota Bharu, Kelantan.
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QM Human anatomy
spellingShingle QM Human anatomy
Radzuan, Hazulin
Myint, Yi Yi
Tun, Ye
Zulkifly, Ahmad Hafiz
The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
description The reduction of capillary luminal area within dermal microcirculation in diabetic foot patients contributes towards the development of foot ulceration and subsequent failure to heal existing ulcers. We studied 42 subjects, involving 10 controls, 16 patients with neuropathic ulcer and 16 patients with neuroischaemic ulcer. The specimens were taken by using skin punch biopsy and were routinely processed for light microscopy. The mean capillary luminal area (LA) and outer area (OA) were performed by calculating and measuring 3 selected capillaries in each slide of every patient and their percentages of ratio were recorded. We noted that there was significant decrement in percentages of LA:OA among the diseased group as compared to the controls, F(2, 39)=17.54, p<0.05. The Tukey post-hoc comparisons showed that the percentages of LA:OA of neuroischemic group (M=31.89, 95% CI [24.79, 39.00]) was significantly reduced as compared to neuropathic group (M=41.76, 95% CI [37.69, 45.82]) since p<0.05. In conclusion, the reduction of dermal capillary luminal area among diabetic foot patients could be due to the alteration in the microvascular hemeorheology, causing basement membrane thickening as the results of the metabolic disease.
format Conference or Workshop Item
author Radzuan, Hazulin
Myint, Yi Yi
Tun, Ye
Zulkifly, Ahmad Hafiz
author_facet Radzuan, Hazulin
Myint, Yi Yi
Tun, Ye
Zulkifly, Ahmad Hafiz
author_sort Radzuan, Hazulin
title The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
title_short The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
title_full The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
title_fullStr The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
title_full_unstemmed The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
title_sort diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
publishDate 2012
url http://irep.iium.edu.my/27249/
http://irep.iium.edu.my/27249/1/MJM_poster_Hazulin.pdf
first_indexed 2023-09-18T20:40:32Z
last_indexed 2023-09-18T20:40:32Z
_version_ 1777409334725050368

Similar Items