The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy

Leptin , a cytokine secreted by adipocytes was suggested to play an important role in many endocrine regulations, including adiposity , puberty and fertility. Leptin levels are strongly correlated with body mass index (BMI) and total fat mass. The role of leptin during pregnancy especially in matern...

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Main Authors:	Mustafa Al-Ahmad, Basma Ezzat, Sulaiman, Waleed Raouf, Mustafa, Nazih Shaban, Kashmola, Muhanad Ali Hamdon, Hajjaj, Muna
Format:	Article
Language:	English
Published:	Academic Information Press 2012
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/27462/ http://irep.iium.edu.my/27462/1/leptin_muna.pdf

id	iium-27462
recordtype	eprints
spelling	iium-274622015-11-24T00:03:25Z http://irep.iium.edu.my/27462/ The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy Mustafa Al-Ahmad, Basma Ezzat Sulaiman, Waleed Raouf Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Hajjaj, Muna R Medicine (General) Leptin , a cytokine secreted by adipocytes was suggested to play an important role in many endocrine regulations, including adiposity , puberty and fertility. Leptin levels are strongly correlated with body mass index (BMI) and total fat mass. The role of leptin during pregnancy especially in maternal-fetal metabolism and intrauterine growth remain unclear .Therefore, the measurement of leptin hormone during pregnancy may eventually be helpful in predicting patient risk of developing gestational diabetes .this study is done to monitor serum leptin changes in pregnant women’s associated with Gestational diabetes (GDM) and to compare them with normal pregnancy with particular emphasis on fasting blood glucose (FBG) concentration.it is a prospective randomized double blind study. 42 pregnant women in 2nd & 3rd trimester Participated in this study, Obesity, hypertension and previous history of diabetes were used as exclusion criteria. The base line level of serum leptin was 6.9±1.8 ng/ml in healthy non-pregnant women’s, whereas the base line values of serum leptin was 1.83 ±1.17 ng/ml and 1.86±1.10 ng/ml for group 1 and group 2 respectively, this difference is statistically significant. However, the values of leptin between group 1 and group 2 were similar. In group 1, serum leptin concentration 1.83±1.17 ng/ml was negatively correlated with FBG 172.3±41.3 mg/dl.whereas in group 2 the negative correlation between the concentration of serum leptin and FBG was very weak.GDM is associated with a significant reduction in the level of serum leptin. This is may be related to an altered relationship between energy requirement, and leptin metabolism in GDM Academic Information Press 2012-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/27462/1/leptin_muna.pdf Mustafa Al-Ahmad, Basma Ezzat and Sulaiman, Waleed Raouf and Mustafa, Nazih Shaban and Kashmola, Muhanad Ali Hamdon and Hajjaj, Muna (2012) The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy. Innova Ciencia, 4 (8). pp. 2-16. ISSN 1333-114X
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mustafa Al-Ahmad, Basma Ezzat Sulaiman, Waleed Raouf Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Hajjaj, Muna The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy
description	Leptin , a cytokine secreted by adipocytes was suggested to play an important role in many endocrine regulations, including adiposity , puberty and fertility. Leptin levels are strongly correlated with body mass index (BMI) and total fat mass. The role of leptin during pregnancy especially in maternal-fetal metabolism and intrauterine growth remain unclear .Therefore, the measurement of leptin hormone during pregnancy may eventually be helpful in predicting patient risk of developing gestational diabetes .this study is done to monitor serum leptin changes in pregnant women’s associated with Gestational diabetes (GDM) and to compare them with normal pregnancy with particular emphasis on fasting blood glucose (FBG) concentration.it is a prospective randomized double blind study. 42 pregnant women in 2nd & 3rd trimester Participated in this study, Obesity, hypertension and previous history of diabetes were used as exclusion criteria. The base line level of serum leptin was 6.9±1.8 ng/ml in healthy non-pregnant women’s, whereas the base line values of serum leptin was 1.83 ±1.17 ng/ml and 1.86±1.10 ng/ml for group 1 and group 2 respectively, this difference is statistically significant. However, the values of leptin between group 1 and group 2 were similar. In group 1, serum leptin concentration 1.83±1.17 ng/ml was negatively correlated with FBG 172.3±41.3 mg/dl.whereas in group 2 the negative correlation between the concentration of serum leptin and FBG was very weak.GDM is associated with a significant reduction in the level of serum leptin. This is may be related to an altered relationship between energy requirement, and leptin metabolism in GDM
format	Article
author	Mustafa Al-Ahmad, Basma Ezzat Sulaiman, Waleed Raouf Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Hajjaj, Muna
author_facet	Mustafa Al-Ahmad, Basma Ezzat Sulaiman, Waleed Raouf Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Hajjaj, Muna
author_sort	Mustafa Al-Ahmad, Basma Ezzat
title	The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy
title_short	The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy
title_full	The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy
title_fullStr	The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy
title_full_unstemmed	The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy
title_sort	relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy
publisher	Academic Information Press
publishDate	2012
url	http://irep.iium.edu.my/27462/ http://irep.iium.edu.my/27462/1/leptin_muna.pdf
first_indexed	2023-09-18T20:40:48Z
last_indexed	2023-09-18T20:40:48Z
_version_	1777409351696252928

The relation between maternal serum leptin level and glucose in gestational diabetes and in normal pregnancy

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