Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia

Introduction: Primary intracerebral hemorrhage (PICH) remains the deadliest and most disabling form of stroke. Despite that, there is paucity of epidemiological data on this condition in Malaysia. The aim of our study was to analyse the frequency of various risk factors among our PICH patients and...

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Main Authors:	Rathor, Mohammad Yousuf, Abdul Rani, Mohammed Fauzi, Ab Rahman, Jamalludin, How, Soon Hin, Abdul Rashid, Mohd Amran, Che Abdullah, Shahrin Tarmizi, Omar, Ahmad Marzuki, Shah, Anis
Format:	Conference or Workshop Item
Language:	English
Published:	Asia Pacific Stroke Conference 2011
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/27571/ http://irep.iium.edu.my/27571/ http://irep.iium.edu.my/27571/1/Asia_Pasific_Stroke_Conference_2011.pdf

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spelling	iium-275712016-03-10T07:01:44Z http://irep.iium.edu.my/27571/ Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis RC Internal medicine Introduction: Primary intracerebral hemorrhage (PICH) remains the deadliest and most disabling form of stroke. Despite that, there is paucity of epidemiological data on this condition in Malaysia. The aim of our study was to analyse the frequency of various risk factors among our PICH patients and determine the predictors of in-hospital mortality. Methods: A prospective study conducted among PICH patients at a tertiary care level hospital. Results: A total of 160 (93 male and 67 female) eligible patients with age range from 25 to 85 years (mean age 58.30 ± 11.44 years) were evaluated. Hypertension was the commonest risk factor (74.4%), followed by diabetes mellitus (18.8%) and cigarette smoking (36.3%). The commonest localization of ICH was lobar (43.8%) followed by basal ganglia / thalamus (28.1 %) and multilobar (13.1%). The overall mortality was 32.5 %. About one third (32.7%) of the deaths occurred within first 24 hours, this rose to 38.5% within first 2 days and 84.6% within one week. The significant independent predictors of acute in- hospital mortality were posterior fossa bleed (OR 11.01; 95% CI 3.21 to 37.81), hematoma volume >60ml (OR 4.72; 95% CI 1.34 to 16.64), mid line shift (OR 3.32; 95% CI 1.05 to 10.50) and intraventricular extension of haemorrhage (OR 5.69; 95% CI 2.24 to 14.47). Conclusion: PICH is associated with high mortality. The characteristics of hematoma and its localization was the most important factor to determine in-hospital mortality. Keywords: Primary intracerebral haemorrhage Asia Pacific Stroke Conference 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/27571/1/Asia_Pasific_Stroke_Conference_2011.pdf Rathor, Mohammad Yousuf and Abdul Rani, Mohammed Fauzi and Ab Rahman, Jamalludin and How, Soon Hin and Abdul Rashid, Mohd Amran and Che Abdullah, Shahrin Tarmizi and Omar, Ahmad Marzuki and Shah, Anis (2011) Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia. In: Asia Pacific Stroke Conference 2011, 29 Sep-1 Oct 2011, Colombo, Sri Lanka. http://www.karger.com/Book/Home/256749
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia
description	Introduction: Primary intracerebral hemorrhage (PICH) remains the deadliest and most disabling form of stroke. Despite that, there is paucity of epidemiological data on this condition in Malaysia. The aim of our study was to analyse the frequency of various risk factors among our PICH patients and determine the predictors of in-hospital mortality. Methods: A prospective study conducted among PICH patients at a tertiary care level hospital. Results: A total of 160 (93 male and 67 female) eligible patients with age range from 25 to 85 years (mean age 58.30 ± 11.44 years) were evaluated. Hypertension was the commonest risk factor (74.4%), followed by diabetes mellitus (18.8%) and cigarette smoking (36.3%). The commonest localization of ICH was lobar (43.8%) followed by basal ganglia / thalamus (28.1 %) and multilobar (13.1%). The overall mortality was 32.5 %. About one third (32.7%) of the deaths occurred within first 24 hours, this rose to 38.5% within first 2 days and 84.6% within one week. The significant independent predictors of acute in- hospital mortality were posterior fossa bleed (OR 11.01; 95% CI 3.21 to 37.81), hematoma volume >60ml (OR 4.72; 95% CI 1.34 to 16.64), mid line shift (OR 3.32; 95% CI 1.05 to 10.50) and intraventricular extension of haemorrhage (OR 5.69; 95% CI 2.24 to 14.47). Conclusion: PICH is associated with high mortality. The characteristics of hematoma and its localization was the most important factor to determine in-hospital mortality. Keywords: Primary intracerebral haemorrhage
format	Conference or Workshop Item
author	Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis
author_facet	Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis
author_sort	Rathor, Mohammad Yousuf
title	Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia
title_short	Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia
title_full	Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia
title_fullStr	Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia
title_full_unstemmed	Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia
title_sort	predictors of in-hospital mortality in primary intracerebral haemorrhage in rural malaysia
publisher	Asia Pacific Stroke Conference
publishDate	2011
url	http://irep.iium.edu.my/27571/ http://irep.iium.edu.my/27571/ http://irep.iium.edu.my/27571/1/Asia_Pasific_Stroke_Conference_2011.pdf
first_indexed	2023-09-18T20:40:56Z
last_indexed	2023-09-18T20:40:56Z
_version_	1777409360041869312

Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia

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