The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation

As the demands in wound care have increased, it is imperative to quickly address this issue at hand. Melastoma malabathricum has been claimed to have astounding treatment in wound repair. This study aims to determine its wound healing potentials by assessing and comparing the rate of proliferation o...

Full description

Bibliographic Details
Main Authors:	Abdull Rasad, Mohammad Syaiful Bahari, Kaderi, Mohd Arifin, Mat Alewi, Nur Aizura, Ahmad Roslen, Nurfariza, Abdullah, Samirah
Format:	Conference or Workshop Item
Language:	English
Published:	IACSIT Press 2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/27906/ http://irep.iium.edu.my/27906/ http://irep.iium.edu.my/27906/1/ICESB__Journal.pdf

id	iium-27906
recordtype	eprints
spelling	iium-279062015-05-22T08:26:01Z http://irep.iium.edu.my/27906/ The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation Abdull Rasad, Mohammad Syaiful Bahari Kaderi, Mohd Arifin Mat Alewi, Nur Aizura Ahmad Roslen, Nurfariza Abdullah, Samirah RS Pharmacy and materia medica As the demands in wound care have increased, it is imperative to quickly address this issue at hand. Melastoma malabathricum has been claimed to have astounding treatment in wound repair. This study aims to determine its wound healing potentials by assessing and comparing the rate of proliferation of fibroblasts, before and after, treatment of M. malabathricum’s methanol and aqueous extracts. The study also aims to compare the potential proliferation of cells between different concentrations of extracts through Methylene Blue Assay (MBA). Results were analyzed through two-way ANOVA using SPSS. The results showed a marked proliferation of cells where 39.3 % and 20.7 % were seen at concentrations A3 and A4 respectively. Concentrations A3 and A4 showed a decrease to 13.2 % and 16.4 % at 48 hours to a negligible proliferation at 72 hours, which may indicate probable impairment in the wound treatment. The methanol extracts revealed a gradual dose-response inhibitory effect throughout all the concentrations, accounting for its toxicity effect on cells. This depicts a time and dose-dependent proliferative effect of M. malabathricum’s aqueous extract on fibroblasts, while its methanol extract had a toxic effect on the cells. IACSIT Press 2012 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/27906/1/ICESB__Journal.pdf Abdull Rasad, Mohammad Syaiful Bahari and Kaderi, Mohd Arifin and Mat Alewi, Nur Aizura and Ahmad Roslen, Nurfariza and Abdullah, Samirah (2012) The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation. In: 2012 2nd International Conference on Environment Science and Biotechnology (ICESB 2012), 22 - 23 December 2012, Kuala Lumpur. 10.7763/IPCBE
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abdull Rasad, Mohammad Syaiful Bahari Kaderi, Mohd Arifin Mat Alewi, Nur Aizura Ahmad Roslen, Nurfariza Abdullah, Samirah The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation
description	As the demands in wound care have increased, it is imperative to quickly address this issue at hand. Melastoma malabathricum has been claimed to have astounding treatment in wound repair. This study aims to determine its wound healing potentials by assessing and comparing the rate of proliferation of fibroblasts, before and after, treatment of M. malabathricum’s methanol and aqueous extracts. The study also aims to compare the potential proliferation of cells between different concentrations of extracts through Methylene Blue Assay (MBA). Results were analyzed through two-way ANOVA using SPSS. The results showed a marked proliferation of cells where 39.3 % and 20.7 % were seen at concentrations A3 and A4 respectively. Concentrations A3 and A4 showed a decrease to 13.2 % and 16.4 % at 48 hours to a negligible proliferation at 72 hours, which may indicate probable impairment in the wound treatment. The methanol extracts revealed a gradual dose-response inhibitory effect throughout all the concentrations, accounting for its toxicity effect on cells. This depicts a time and dose-dependent proliferative effect of M. malabathricum’s aqueous extract on fibroblasts, while its methanol extract had a toxic effect on the cells.
format	Conference or Workshop Item
author	Abdull Rasad, Mohammad Syaiful Bahari Kaderi, Mohd Arifin Mat Alewi, Nur Aizura Ahmad Roslen, Nurfariza Abdullah, Samirah
author_facet	Abdull Rasad, Mohammad Syaiful Bahari Kaderi, Mohd Arifin Mat Alewi, Nur Aizura Ahmad Roslen, Nurfariza Abdullah, Samirah
author_sort	Abdull Rasad, Mohammad Syaiful Bahari
title	The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation
title_short	The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation
title_full	The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation
title_fullStr	The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation
title_full_unstemmed	The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation
title_sort	effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation
publisher	IACSIT Press
publishDate	2012
url	http://irep.iium.edu.my/27906/ http://irep.iium.edu.my/27906/ http://irep.iium.edu.my/27906/1/ICESB__Journal.pdf
first_indexed	2023-09-18T20:41:20Z
last_indexed	2023-09-18T20:41:20Z
_version_	1777409385331425280

The effects of in vitro treatment of melastoma malabathricum on fibroblast proliferation

Similar Items