Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines

Benzimidazoles 1-4 were obtained using modified synthesis methods and studied for their ability to inhibit cell proliferation of colon cancer cell HCT-116 and breast cancer cell MCF-7 using MTT assays. In the HCT-116 cell line, benzimidazole 2 was found to have an IC50 value of 16.2±3.85 μg/mL and...

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Main Authors:	Al-Douh, Mohammed Hadi, Sahib, Hayder, Osman, Hasnah, Abd Hamid, Shafida, Salhimi, Salizawati M
Format:	Article
Language:	English
Published:	National Cancer Center, Korea. 2012
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/1/Anti-Proliferation_Effects_of_Benzimidazole_Derivatives_on.pdf

id	iium-28843
recordtype	eprints
spelling	iium-288432013-02-13T03:06:24Z http://irep.iium.edu.my/28843/ Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines Al-Douh, Mohammed Hadi Sahib, Hayder Osman, Hasnah Abd Hamid, Shafida Salhimi, Salizawati M Q Science (General) Benzimidazoles 1-4 were obtained using modified synthesis methods and studied for their ability to inhibit cell proliferation of colon cancer cell HCT-116 and breast cancer cell MCF-7 using MTT assays. In the HCT-116 cell line, benzimidazole 2 was found to have an IC50 value of 16.2±3.85 μg/mL and benzimidazole 1 a value of 28.5±2.91 μg/mL, while that for benzimidazole 4 was 24.08±0.31 μg/mL. In the MCF-7 cell line, benzimidazole 4 had an IC50 value of 8.86±1.10 μg/mL, benzimidazole 2 a value of 30.29±6.39 μg/mL, and benzimidazole 1 a value of 31.2±4.49 μg/mL. Benzimidazole 3 exerted no cytotoxity in either of the cell lines, with IC50 values >50 μg/mL. The results suggest that benzimidazoles derivatives may have chemotherapeutic potential for treatment of both colon and breast cancers. National Cancer Center, Korea. 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28843/1/Anti-Proliferation_Effects_of_Benzimidazole_Derivatives_on.pdf Al-Douh, Mohammed Hadi and Sahib, Hayder and Osman, Hasnah and Abd Hamid, Shafida and Salhimi, Salizawati M (2012) Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines. Asian Pacific Journal of Cancer Prevention, 13 (2012). pp. 4075-4079. ISSN 1513-7368 http://www.apocpcontrol.org/page/apjcp_issues.php DOI:http://dx.doi.org/10.7314/APJCP.2012.13.8.4075
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Al-Douh, Mohammed Hadi Sahib, Hayder Osman, Hasnah Abd Hamid, Shafida Salhimi, Salizawati M Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
description	Benzimidazoles 1-4 were obtained using modified synthesis methods and studied for their ability to inhibit cell proliferation of colon cancer cell HCT-116 and breast cancer cell MCF-7 using MTT assays. In the HCT-116 cell line, benzimidazole 2 was found to have an IC50 value of 16.2±3.85 μg/mL and benzimidazole 1 a value of 28.5±2.91 μg/mL, while that for benzimidazole 4 was 24.08±0.31 μg/mL. In the MCF-7 cell line, benzimidazole 4 had an IC50 value of 8.86±1.10 μg/mL, benzimidazole 2 a value of 30.29±6.39 μg/mL, and benzimidazole 1 a value of 31.2±4.49 μg/mL. Benzimidazole 3 exerted no cytotoxity in either of the cell lines, with IC50 values >50 μg/mL. The results suggest that benzimidazoles derivatives may have chemotherapeutic potential for treatment of both colon and breast cancers.
format	Article
author	Al-Douh, Mohammed Hadi Sahib, Hayder Osman, Hasnah Abd Hamid, Shafida Salhimi, Salizawati M
author_facet	Al-Douh, Mohammed Hadi Sahib, Hayder Osman, Hasnah Abd Hamid, Shafida Salhimi, Salizawati M
author_sort	Al-Douh, Mohammed Hadi
title	Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
title_short	Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
title_full	Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
title_fullStr	Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
title_full_unstemmed	Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
title_sort	anti-proliferation effects of benzimidazole derivatives on hct-116 colon cancer and mcf-7 breast cancer cell lines
publisher	National Cancer Center, Korea.
publishDate	2012
url	http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/1/Anti-Proliferation_Effects_of_Benzimidazole_Derivatives_on.pdf
first_indexed	2023-09-18T20:42:22Z
last_indexed	2023-09-18T20:42:22Z
_version_	1777409450594795520

Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines

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