Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement

BACKGROUND: Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) has good cardiovascular and phytoestrogenic properties. The OPLE (0.5 g day(-1) ) was supplemented to young, healthy, adult human volunteers, and their cognitive learning abilities were compared to placebo-controlled groups...

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Main Authors:	Mohamed, Suhaila, Tan, Lee Ming, Md. Jaffri, Juliana
Format:	Article
Language:	English
Published:	Elsevier Inc. 2013
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/28879/ http://irep.iium.edu.my/28879/ http://irep.iium.edu.my/28879/ http://irep.iium.edu.my/28879/1/cognition_ople_jsfa.pdf

id	iium-28879
recordtype	eprints
spelling	iium-288792013-03-19T07:10:17Z http://irep.iium.edu.my/28879/ Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement Mohamed, Suhaila Tan, Lee Ming Md. Jaffri, Juliana RS Pharmacy and materia medica BACKGROUND: Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) has good cardiovascular and phytoestrogenic properties. The OPLE (0.5 g day(-1) ) was supplemented to young, healthy, adult human volunteers, and their cognitive learning abilities were compared to placebo-controlled groups (N = 15). Their short-term memories, spatial visualisations, processing speeds, and language skills, were assessed over 2 months by cognitive tests computer programs. RESULTS: Relative to the controls, volunteers taking OPLE had improved (P < 0.05) short-term memory, after 1 month of intervention which became highly significant (P < 0.005) after 2 months. The spatial visualisation ability and processing speed improved (P < 0.05) after 2 months consumption. The dietary OPLE showed neuroprotection in nitric oxide-deficient rats. The mechanisms involved systemic and cellular modulations that eventually enhance neuron survival. The longer the duration of OPLE consumption, the more significant was the enhancement, as shown for short-term memory. CONCLUSION: This is the first report on the cognitive-enhancing effects of dietary OPLE in humans. The computer-assisted cognitive tests were simple, low in cost, errors and man hours, and hence are better than conventional cognitive test methods. In rats, the equivalent OPLE dose showed brain antioxidant enzymes modulating properties and neuroprotection under nitric oxide deficiency, with possibly neurogenesis in normal rats. This supported the effects in humans. Copyright Â© 2012 Society of Chemical Industry. Elsevier Inc. 2013-03-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28879/1/cognition_ople_jsfa.pdf Mohamed, Suhaila and Tan, Lee Ming and Md. Jaffri, Juliana (2013) Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement. Journal of the Science of Food and Agriculture, 93 (4). pp. 819-827. ISSN 0022-5142 http://onlinelibrary.wiley.com/doi/10.1002/jsfa.5802/abstract;jsessionid=CCCCFF9B4D9AF1C7BD53A2A3FE635BDA.d03t02 10.1002/jsfa.5802
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohamed, Suhaila Tan, Lee Ming Md. Jaffri, Juliana Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement
description	BACKGROUND: Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) has good cardiovascular and phytoestrogenic properties. The OPLE (0.5 g day(-1) ) was supplemented to young, healthy, adult human volunteers, and their cognitive learning abilities were compared to placebo-controlled groups (N = 15). Their short-term memories, spatial visualisations, processing speeds, and language skills, were assessed over 2 months by cognitive tests computer programs. RESULTS: Relative to the controls, volunteers taking OPLE had improved (P < 0.05) short-term memory, after 1 month of intervention which became highly significant (P < 0.005) after 2 months. The spatial visualisation ability and processing speed improved (P < 0.05) after 2 months consumption. The dietary OPLE showed neuroprotection in nitric oxide-deficient rats. The mechanisms involved systemic and cellular modulations that eventually enhance neuron survival. The longer the duration of OPLE consumption, the more significant was the enhancement, as shown for short-term memory. CONCLUSION: This is the first report on the cognitive-enhancing effects of dietary OPLE in humans. The computer-assisted cognitive tests were simple, low in cost, errors and man hours, and hence are better than conventional cognitive test methods. In rats, the equivalent OPLE dose showed brain antioxidant enzymes modulating properties and neuroprotection under nitric oxide deficiency, with possibly neurogenesis in normal rats. This supported the effects in humans. Copyright Â© 2012 Society of Chemical Industry.
format	Article
author	Mohamed, Suhaila Tan, Lee Ming Md. Jaffri, Juliana
author_facet	Mohamed, Suhaila Tan, Lee Ming Md. Jaffri, Juliana
author_sort	Mohamed, Suhaila
title	Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement
title_short	Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement
title_full	Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement
title_fullStr	Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement
title_full_unstemmed	Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement
title_sort	cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement
publisher	Elsevier Inc.
publishDate	2013
url	http://irep.iium.edu.my/28879/ http://irep.iium.edu.my/28879/ http://irep.iium.edu.my/28879/ http://irep.iium.edu.my/28879/1/cognition_ople_jsfa.pdf
first_indexed	2023-09-18T20:42:25Z
last_indexed	2023-09-18T20:42:25Z
_version_	1777409454002667520

Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement

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