Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience

Background: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on microscopic marginal status. Met...

Full description

Bibliographic Details
Main Authors:	Sharifudin, Mohd Ariff, Wan, Zulmi, Wan Ismail, Wan Faisham Numan, Mat Zin, Nor Azman, Mohamed Amir, Nawaz Hussain
Format:	Article
Language:	English English English
Published:	Malaysian Orthopaedic Association 2012
Subjects:	RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/29399/ http://irep.iium.edu.my/29399/ http://irep.iium.edu.my/29399/17/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Cover%29.pdf http://irep.iium.edu.my/29399/18/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Content_Page_30%29.pdf http://irep.iium.edu.my/29399/22/Surgical_Margin_Abstract.pdf

id	iium-29399
recordtype	eprints
spelling	iium-293992013-03-07T02:06:11Z http://irep.iium.edu.my/29399/ Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics Background: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on microscopic marginal status. Method: We analyzed 53 consecutive patients surgically treated throughout a 10-year span at a single referral centre between 2001 and 2010. Various clinicopathologic factors were analyzed in relation to the oncological outcomes of overall survival and local recurrence. Results: Majority of cases were primary tumours (90%). Chondrosarcoma (n = 11) and osteosarcoma (n = 10) were the most common diagnoses. Eighteen patients underwent external hemipelvectomy and 35 patients were subjected to internal hemipelvectomy resection of various types. Average age was 40.12 years (range: 12-79 years). Average follow up is 10.4 months (range: 0-108 months). Thirty-seven patients underwent macroscopically wide resection but only 46% had clear marginal statuses. Conclusion: Positive surgical margins had a weak adverse prognostic effect, which was more pronounced for those patients escaping an early relapse. Other prognostic factors and relation to the oncological outcomes are further outlined in the article. Malaysian Orthopaedic Association 2012-06-17 Article PeerReviewed application/pdf en http://irep.iium.edu.my/29399/17/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Cover%29.pdf application/pdf en http://irep.iium.edu.my/29399/18/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Content_Page_30%29.pdf application/pdf en http://irep.iium.edu.my/29399/22/Surgical_Margin_Abstract.pdf Sharifudin, Mohd Ariff and Wan, Zulmi and Wan Ismail, Wan Faisham Numan and Mat Zin, Nor Azman and Mohamed Amir, Nawaz Hussain (2012) Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience. Malaysian Orthopaedic Journal, 6 (2sup.A). p. 35. ISSN 1985-2533 http://moa-home.com/moa2012/index.htm
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics
spellingShingle	RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
description	Background: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on microscopic marginal status. Method: We analyzed 53 consecutive patients surgically treated throughout a 10-year span at a single referral centre between 2001 and 2010. Various clinicopathologic factors were analyzed in relation to the oncological outcomes of overall survival and local recurrence. Results: Majority of cases were primary tumours (90%). Chondrosarcoma (n = 11) and osteosarcoma (n = 10) were the most common diagnoses. Eighteen patients underwent external hemipelvectomy and 35 patients were subjected to internal hemipelvectomy resection of various types. Average age was 40.12 years (range: 12-79 years). Average follow up is 10.4 months (range: 0-108 months). Thirty-seven patients underwent macroscopically wide resection but only 46% had clear marginal statuses. Conclusion: Positive surgical margins had a weak adverse prognostic effect, which was more pronounced for those patients escaping an early relapse. Other prognostic factors and relation to the oncological outcomes are further outlined in the article.
format	Article
author	Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain
author_facet	Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain
author_sort	Sharifudin, Mohd Ariff
title	Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_short	Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_full	Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_fullStr	Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_full_unstemmed	Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience
title_sort	surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of husm experience
publisher	Malaysian Orthopaedic Association
publishDate	2012
url	http://irep.iium.edu.my/29399/ http://irep.iium.edu.my/29399/ http://irep.iium.edu.my/29399/17/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Cover%29.pdf http://irep.iium.edu.my/29399/18/Malaysian_Orthopaedic_Journal_-_2012%2C_Volume_6%2C_Issue_2._Supplement_A._%28Content_Page_30%29.pdf http://irep.iium.edu.my/29399/22/Surgical_Margin_Abstract.pdf
first_indexed	2023-09-18T20:43:10Z
last_indexed	2023-09-18T20:43:10Z
_version_	1777409500279472128

Surgical margins and oncological outcomes of hemipelvectomies for bone and soft tissue tumours – a decade of HUSM experience

Similar Items