Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin

New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P - 1, Z = 2, V = 612.92(3) A ° 3 and unit cell parameters a = 6.8540(2) A ° , b...

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Main Authors:	Abdul Manan, Mohd Abdul Fatah, Mohamed Tahir, Mohamed Ibrahim, Crouse, Karen Anne, How, Fiona Ni Foong, Watkins, David J.
Format:	Article
Language:	English
Published:	SpringerLink 2012
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/1/JOCC_42%282%29_2012.pdf

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recordtype	eprints
spelling	iium-294052013-03-11T04:23:24Z http://irep.iium.edu.my/29405/ Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkins, David J. QD Chemistry New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P - 1, Z = 2, V = 612.92(3) A ° 3 and unit cell parameters a = 6.8540(2) A ° , b = 8.3022(2) A ° , c = 11.5243(4) A ° , a = 79.8186(13)�, b = 90.5224(14)� and c = 72.1362(13)�. Crystal structure reveals that the compound exists in the thione form with the methylisatin moiety is trans with respect to the C3–N2 and C3–S4 bonds whereas the methyl group of the dithiocarbazate moiety is cis with respect to the C3–N2 and C3–S5 bonds. The Schiff base was found to be selectively active against the selected Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus)with the inhibition zones of 16 and 12 mm, respectively. SpringerLink 2012-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/29405/1/JOCC_42%282%29_2012.pdf Abdul Manan, Mohd Abdul Fatah and Mohamed Tahir, Mohamed Ibrahim and Crouse, Karen Anne and How, Fiona Ni Foong and Watkins, David J. (2012) Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. Journal of Chemical Crystallography, 42 (2). pp. 173-179. ISSN 1074-1542 http://link.springer.com/article/10.1007%2Fs10870-011-0220-6?LI=true# 10.1007/s10870-011-0220-6
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkins, David J. Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin
description	New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P - 1, Z = 2, V = 612.92(3) A ° 3 and unit cell parameters a = 6.8540(2) A ° , b = 8.3022(2) A ° , c = 11.5243(4) A ° , a = 79.8186(13)�, b = 90.5224(14)� and c = 72.1362(13)�. Crystal structure reveals that the compound exists in the thione form with the methylisatin moiety is trans with respect to the C3–N2 and C3–S4 bonds whereas the methyl group of the dithiocarbazate moiety is cis with respect to the C3–N2 and C3–S5 bonds. The Schiff base was found to be selectively active against the selected Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus)with the inhibition zones of 16 and 12 mm, respectively.
format	Article
author	Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkins, David J.
author_facet	Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkins, David J.
author_sort	Abdul Manan, Mohd Abdul Fatah
title	Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin
title_short	Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin
title_full	Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin
title_fullStr	Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin
title_full_unstemmed	Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin
title_sort	synthesis, characterization and antibacterial activity of schiff base derived from s-methyldithiocarbazate and methylisatin
publisher	SpringerLink
publishDate	2012
url	http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/1/JOCC_42%282%29_2012.pdf
first_indexed	2023-09-18T20:43:10Z
last_indexed	2023-09-18T20:43:10Z
_version_	1777409500699951104

Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin

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