Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes

A tridentate nitrogen-sulfur Schiff base, 3-methylbenzyl 2-(6-methylpyridin-2-ylmethylene)hydrazine carbodithioate (6mpyS3M), was synthesized by condensation of 6-methylpyridine-2-aldehyde with S-3-methylbenzyldithiocarbazate. It crystallized in space group P 21/n. It displayed intermolecular N–H...

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Main Authors:	Ravoof, Thahira B. S. A., Crouse, Karen A., Tahir, M. Ibrahim M., How, Fiona Ni Foong, Rosli, Rozita, Watkins, David J.
Format:	Article
Language:	English
Published:	Springer 2010
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/306/ http://irep.iium.edu.my/306/ http://irep.iium.edu.my/306/ http://irep.iium.edu.my/306/1/TMC_3-methylbenzyl_2-%286-methyl_pyridin-2-ylmethylene%29hydrazine.pdf

id	iium-306
recordtype	eprints
spelling	iium-3062012-02-23T15:17:18Z http://irep.iium.edu.my/306/ Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes Ravoof, Thahira B. S. A. Crouse, Karen A. Tahir, M. Ibrahim M. How, Fiona Ni Foong Rosli, Rozita Watkins, David J. QD Chemistry A tridentate nitrogen-sulfur Schiff base, 3-methylbenzyl 2-(6-methylpyridin-2-ylmethylene)hydrazine carbodithioate (6mpyS3M), was synthesized by condensation of 6-methylpyridine-2-aldehyde with S-3-methylbenzyldithiocarbazate. It crystallized in space group P 21/n. It displayed intermolecular N–H...N hydrogen bonding between the a-nitrogen and the pyridyl nitrogen. The thione sulfur is in a trans position with respect to the 6-methylpyridine fragment across the C–N bond but adopts a cis position with the 3-methylbenzyl fragment through the C–S bond. Octahedral complexes containing two 6mpyS3M ligands were prepared with Cu(II), Ni(II), Zn(II) and Cd(II). 6mpyS3M and its metal complexes were assayed against selected microbes and two breast cancer cell lines. 6mpyS3M was strongly active against both cancer cell lines. Its metal complexes showed high selectivity with Cu(II), Ni(II) and Zn(II) complexes strongly active against only one of the cancer cell lines, whereas the Cd(II) complex was strongly active only against the other. Only Cu(II) and Cd(II)complexes were active against some of the bacteria. Springer 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/306/1/TMC_3-methylbenzyl_2-%286-methyl_pyridin-2-ylmethylene%29hydrazine.pdf Ravoof, Thahira B. S. A. and Crouse, Karen A. and Tahir, M. Ibrahim M. and How, Fiona Ni Foong and Rosli, Rozita and Watkins, David J. (2010) Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes. Transition Metal Chemistry, 35 (7). pp. 871-876. ISSN 0340-4285 http://www.springer.com/chemistry/journal/11243 10.1007/s11243-010-9406-6
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Ravoof, Thahira B. S. A. Crouse, Karen A. Tahir, M. Ibrahim M. How, Fiona Ni Foong Rosli, Rozita Watkins, David J. Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes
description	A tridentate nitrogen-sulfur Schiff base, 3-methylbenzyl 2-(6-methylpyridin-2-ylmethylene)hydrazine carbodithioate (6mpyS3M), was synthesized by condensation of 6-methylpyridine-2-aldehyde with S-3-methylbenzyldithiocarbazate. It crystallized in space group P 21/n. It displayed intermolecular N–H...N hydrogen bonding between the a-nitrogen and the pyridyl nitrogen. The thione sulfur is in a trans position with respect to the 6-methylpyridine fragment across the C–N bond but adopts a cis position with the 3-methylbenzyl fragment through the C–S bond. Octahedral complexes containing two 6mpyS3M ligands were prepared with Cu(II), Ni(II), Zn(II) and Cd(II). 6mpyS3M and its metal complexes were assayed against selected microbes and two breast cancer cell lines. 6mpyS3M was strongly active against both cancer cell lines. Its metal complexes showed high selectivity with Cu(II), Ni(II) and Zn(II) complexes strongly active against only one of the cancer cell lines, whereas the Cd(II) complex was strongly active only against the other. Only Cu(II) and Cd(II)complexes were active against some of the bacteria.
format	Article
author	Ravoof, Thahira B. S. A. Crouse, Karen A. Tahir, M. Ibrahim M. How, Fiona Ni Foong Rosli, Rozita Watkins, David J.
author_facet	Ravoof, Thahira B. S. A. Crouse, Karen A. Tahir, M. Ibrahim M. How, Fiona Ni Foong Rosli, Rozita Watkins, David J.
author_sort	Ravoof, Thahira B. S. A.
title	Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes
title_short	Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes
title_full	Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes
title_fullStr	Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes
title_full_unstemmed	Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes
title_sort	synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes
publisher	Springer
publishDate	2010
url	http://irep.iium.edu.my/306/ http://irep.iium.edu.my/306/ http://irep.iium.edu.my/306/ http://irep.iium.edu.my/306/1/TMC_3-methylbenzyl_2-%286-methyl_pyridin-2-ylmethylene%29hydrazine.pdf
first_indexed	2023-09-18T20:07:26Z
last_indexed	2023-09-18T20:07:26Z
_version_	1777407252489043968

Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes

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